Neonatal SHIV infection in rhesus macaques elicited heterologous HIV-1-neutralizing antibodies.
CP: Immunology
HIV-1 Env glycosylation
HIV-1 env evolution
autologous SHIV NAbs
germinal center activity
neonatal SHIV infection
neonatal heterologous NAbs
neonatal immunity
transcriptomics
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
28 03 2023
28 03 2023
Historique:
received:
15
10
2022
revised:
21
12
2022
accepted:
28
02
2023
medline:
3
4
2023
pubmed:
17
3
2023
entrez:
16
3
2023
Statut:
ppublish
Résumé
Infants and children infected with human immunodeficiency virus (HIV)-1 have been shown to develop neutralizing antibodies (nAbs) against heterologous HIV-1 strains, characteristic of broadly nAbs (bnAbs). Thus, having a neonatal model for the induction of heterologous HIV-1 nAbs may provide insights into the mechanisms of neonatal bnAb development. Here, we describe a neonatal model for heterologous HIV-1 nAb induction in pathogenic simian-HIV (SHIV)-infected rhesus macaques (RMs). Viral envelope (env) evolution showed mutations at multiple sites, including nAb epitopes. All 13 RMs generated plasma autologous HIV-1 nAbs. However, 8/13 (62%) RMs generated heterologous HIV-1 nAbs with increasing potency over time, albeit with limited breadth, and mapped to multiple nAb epitopes, suggestive of a polyclonal response. Moreover, plasma heterologous HIV-1 nAb development was associated with antigen-specific, lymph-node-derived germinal center activity. We define a neonatal model for heterologous HIV-1 nAb induction that may inform future pediatric HIV-1 vaccines for bnAb induction in infants and children.
Identifiants
pubmed: 36924501
pii: S2211-1247(23)00266-8
doi: 10.1016/j.celrep.2023.112255
pmc: PMC10117998
mid: NIHMS1887308
pii:
doi:
Substances chimiques
Broadly Neutralizing Antibodies
0
HIV Antibodies
0
Antibodies, Neutralizing
0
Epitopes
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
112255Subventions
Organisme : NIAID NIH HHS
ID : P01 AI048280
Pays : United States
Organisme : NIAID NIH HHS
ID : P30 AI064518
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI140897
Pays : United States
Organisme : NIAID NIH HHS
ID : UC6 AI058607
Pays : United States
Organisme : NIMH NIH HHS
ID : P01 MH105303
Pays : United States
Organisme : NIAID NIH HHS
ID : HHSN272201800004C
Pays : United States
Informations de copyright
Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.
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