HIV-1 gp120 protein promotes HAND through the calcineurin pathway activation.
Calcineurin
Fusion/Fission
HIV-1 gp120
Neurodegenerative disease
Journal
Mitochondrion
ISSN: 1872-8278
Titre abrégé: Mitochondrion
Pays: Netherlands
ID NLM: 100968751
Informations de publication
Date de publication:
05 2023
05 2023
Historique:
received:
26
07
2022
revised:
21
02
2023
accepted:
08
03
2023
pmc-release:
01
05
2024
medline:
22
5
2023
pubmed:
17
3
2023
entrez:
16
3
2023
Statut:
ppublish
Résumé
For over two decades, highly active antiretroviral therapy (HAART) was able to help prolong the life expectancy of people living with HIV-1 (PLWH) and eliminate the virus to an undetectable level. However, an increased prevalence of HIV- associated neurocognitive disorders (HAND) was observed. These symptoms range from neuronal dysfunction to cell death. Among the markers of neuronal deregulation, we cite the alteration of synaptic plasticity and neuronal communications. Clinically, these dysfunctions led to neurocognitive disorders such as learning alteration and loss of spatial memory, which promote premature brain aging even in HAART-treated patients. In support of these observations, we showed that the gp120 protein deregulates miR-499-5p and its downstream target, the calcineurin (CaN) protein. The gp120 protein also promotes the accumulation of calcium (Ca
Identifiants
pubmed: 36925028
pii: S1567-7249(23)00030-2
doi: 10.1016/j.mito.2023.03.003
pmc: PMC10484070
mid: NIHMS1883994
pii:
doi:
Substances chimiques
Calcineurin
EC 3.1.3.16
MicroRNAs
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
31-40Subventions
Organisme : NIDA NIH HHS
ID : P50 DA026306
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH093331
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH105330
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH104131
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS076402
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH087332
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS040673
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM114308
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG054411
Pays : United States
Informations de copyright
Copyright © 2023 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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