Intestinal complications in Brazilian patients with ulcerative colitis treated with conventional therapy between 2011 and 2020.

BACKGROUND

This was an observational, descriptive, and retrospective study from 2011 to 2020 from the Department of Informatics of the Brazilian Healthcare System database.

AIM

To describe the intestinal complications (IC) of patients with ulcerative colitis (UC) who started conventional therapies in Brazil´s public Healthcare system.

METHODS

Patients ≥ 18 years of age who had at least one claim related to UC 10

RESULTS

In total, 41229 UC patients were included (median age, 48 years; 65% women) and the median (interquartile range) follow-up period was 3.3 (1.8-5.3) years. Conventional therapy used during follow-up period included: mesalazine (87%), sulfasalazine (15%), azathioprine (16%) or methotrexate (1%) with a median duration of 1.9 (0.8-4.0) years. Overall IR of IC was 3.2 cases per 100 PY. Among the IC claims, 54% were related to associated diseases, 20% to procedures and 26% to hospitalizations. The overall annual incidence of IC was 2.9%, 2.6% and 2.5% in the first, second and third year after the first claim for therapy (index date), respectively. Over the first 3 years, the annual IR of UC-related hospitalizations ranged from 0.8% to 1.1%; associated diseases from 0.9% to 1.2% - in which anus or rectum disease, and malignant neoplasia of colon were the most frequently reported; and procedure events from 0.6% to 0.7%, being intestinal resection and polyp removal the most frequent ones.

CONCLUSION

Study shows that UC patients under conventional therapy seem to present progression of disease developing some IC, which may have a negative impact on patients and the burden on the health system.

Informations de copyright

©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.

Déclaration de conflit d'intérêts

Conflict-of-interest statement: Martins AL served on the advisory board of Takeda, AbbVie, Janssen, Pfizer and Amgen and is a speaker for Amgen and Janssen. Galhardi Gasparini R is a speaker for Janssen, Takeda and AbbVie. Sassaki LY is a speaker for Janssen and Takeda and participated in the advisory boards of Takeda and AbbVie. Saad-Hossne R is a speaker and on the advisory boards for AbbVie, Takeda, Janssen, Pfizer, Fresenius and Amgen, as well as a speaker for Novartis. AMVR is an employee of IQVIA Brazil. Marcolino T, Barreto TB and Yang Santos C are employees of Takeda Pharmaceutical Brazil.