Preclinical safety and efficacy of a therapeutic antibody that targets SARS-CoV-2 at the sotrovimab face but is escaped by Omicron.

Immunology Virology

Journal

iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038

Informations de publication

Date de publication:
21 Apr 2023
Historique:
received: 08 08 2022
revised: 15 12 2022
accepted: 22 02 2023
entrez: 17 3 2023
pubmed: 18 3 2023
medline: 18 3 2023
Statut: ppublish

Résumé

The recurrent emerging of novel viral variants of concern (VOCs) with evasion of preexisting antibody immunity upholds severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) case numbers and maintains a persistent demand for updated therapies. We selected the patient-derived antibody CV38-142 based on its potency and breadth against the VOCs Alpha, Beta, Gamma, and Delta for preclinical development into a therapeutic. CV38-142 showed

Identifiants

DOI: 10.1016/j.isci.2023.106323 PMID: 36925720 PMC: PMC9979625
pubmed: 36925720
doi: 10.1016/j.isci.2023.106323
pii: S2589-0042(23)00400-5
pmc: PMC9979625
doi:

Types de publication

Journal Article

Langues

eng

Pagination

106323

Informations de copyright

© 2023 The Author(s).

Déclaration de conflit d'intérêts

The German Center for Neurodegenerative Diseases (DZNE) and Charité-Universitätsmedizin Berlin have filed a patent application (application number: PCT/EP2021/064,352) on antibodies for the treatment of SARS-CoV-2 infection on which J.K., S.M.R., H.-C.K., E.S.-S., L.E.S., V.M.C., and H.P. are named as inventors. V.M.C. is named together with Euroimmun GmbH on a patent application filed recently regarding the diagnostic of SARS-CoV-2 by antibody testing. S.E., V.N., M.M., S.K., S.H., P.H., and U.J. are employees of Miltenyi Biotec B.V. & Co. KG.

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Auteurs

Jakob Kreye (J)

German Center for Neurodegenerative Diseases (DZNE) Berlin, 10117 Berlin, Germany.
Helmholtz Innovation Lab BaoBab (Brain Antibody-omics and B-cell Lab), 10117 Berlin, Germany.
Department of Neurology and Experimental Neurology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.
Department of Pediatric Neurology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.
Berlin Institute of Health at Charité, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.

S Momsen Reincke (SM)

German Center for Neurodegenerative Diseases (DZNE) Berlin, 10117 Berlin, Germany.
Helmholtz Innovation Lab BaoBab (Brain Antibody-omics and B-cell Lab), 10117 Berlin, Germany.
Department of Neurology and Experimental Neurology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.
Berlin Institute of Health at Charité, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.

Stefan Edelburg (S)

Miltenyi Biotec B.V. & Co. KG, 51429 Bergisch Gladbach, Germany.

Lara M Jeworowski (LM)

Institute of Virology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.
German Centre for Infection Research (DZIF), 10117 Berlin, Germany.

Hans-Christian Kornau (HC)

German Center for Neurodegenerative Diseases (DZNE) Berlin, 10117 Berlin, Germany.
Neuroscience Research Center (NWFZ), Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.

Jakob Trimpert (J)

Institute of Virology, Freie Universität Berlin, 14163 Berlin, Germany.

Peter Hombach (P)

Miltenyi Biotec B.V. & Co. KG, 51429 Bergisch Gladbach, Germany.

Sophia Halbe (S)

Miltenyi Biotec B.V. & Co. KG, 51429 Bergisch Gladbach, Germany.

Volker Nölle (V)

Miltenyi Biotec B.V. & Co. KG, 51429 Bergisch Gladbach, Germany.

Martin Meyer (M)

Miltenyi Biotec B.V. & Co. KG, 51429 Bergisch Gladbach, Germany.

Stefanie Kattenbach (S)

Miltenyi Biotec B.V. & Co. KG, 51429 Bergisch Gladbach, Germany.

Elisa Sánchez-Sendin (E)

German Center for Neurodegenerative Diseases (DZNE) Berlin, 10117 Berlin, Germany.
Helmholtz Innovation Lab BaoBab (Brain Antibody-omics and B-cell Lab), 10117 Berlin, Germany.
Department of Neurology and Experimental Neurology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.

Marie L Schmidt (ML)

Institute of Virology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.
German Centre for Infection Research (DZIF), 10117 Berlin, Germany.

Tatjana Schwarz (T)

Institute of Virology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.
German Centre for Infection Research (DZIF), 10117 Berlin, Germany.

Ruben Rose (R)

Institute for Infection Medicine, Christian-Albrechts-Universität zu Kiel and University Medical Center Schleswig-Holstein, 24105 Kiel, Germany.

Andi Krumbholz (A)

Institute for Infection Medicine, Christian-Albrechts-Universität zu Kiel and University Medical Center Schleswig-Holstein, 24105 Kiel, Germany.
Labor Dr. Krause & Kollegen MVZ GmbH, 24106 Kiel, Germany.

Sophie Merz (S)

IDEXX Laboratories, 70806 Kornwestheim, Germany.

Julia M Adler (JM)

Institute of Virology, Freie Universität Berlin, 14163 Berlin, Germany.

Kathrin Eschke (K)

Institute of Virology, Freie Universität Berlin, 14163 Berlin, Germany.

Azza Abdelgawad (A)

Institute of Virology, Freie Universität Berlin, 14163 Berlin, Germany.

Dietmar Schmitz (D)

German Center for Neurodegenerative Diseases (DZNE) Berlin, 10117 Berlin, Germany.
Neuroscience Research Center (NWFZ), Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.
Einstein Center for Neuroscience, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.
NeuroCure Cluster of Excellence, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.
Bernstein Center for Computational Neuroscience, Humboldt-Universität zu Berlin, 10115 Berlin, Germany.

Leif E Sander (LE)

Department of Infectious Diseases and Respiratory Medicine, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.

Uwe Janssen (U)

Miltenyi Biotec B.V. & Co. KG, 51429 Bergisch Gladbach, Germany.

Victor M Corman (VM)

Berlin Institute of Health at Charité, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
Institute of Virology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.
German Centre for Infection Research (DZIF), 10117 Berlin, Germany.
Labor Berlin-Charité Vivantes GmbH, Berlin, Germany.

Harald Prüss (H)

German Center for Neurodegenerative Diseases (DZNE) Berlin, 10117 Berlin, Germany.
Helmholtz Innovation Lab BaoBab (Brain Antibody-omics and B-cell Lab), 10117 Berlin, Germany.
Department of Neurology and Experimental Neurology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.

Classifications MeSH