Allergic asthma: An indication for allergen immunotherapy.
allergen-specific immunotherapy (AIT)
allergic asthma
asthma
environmental allergens
meta-analyses
Journal
Allergologie select
ISSN: 2512-8957
Titre abrégé: Allergol Select
Pays: Germany
ID NLM: 101722686
Informations de publication
Date de publication:
2023
2023
Historique:
received:
16
03
2022
accepted:
16
11
2022
entrez:
17
3
2023
pubmed:
18
3
2023
medline:
18
3
2023
Statut:
epublish
Résumé
. Allergen immunotherapy (AIT) as a validated, disease-modifying treatment is nowadays a widely recommended therapy option for allergic rhinitis and allergic asthma. The registration of allergen extracts used for AIT is based on allergen standardization, dose finding trials, and phase 3 trials proving their efficacy in high-quality, statistically significant randomized clinical trials. Real-world evidence (RWE) studies confirm the clinical relevance of these findings. The most data are available for the treatment of patients suffering from allergic rhinitis. Due to the similar inflammatory mechanisms, allergic rhinitis is often associated with allergic asthma. AIT, which induces tolerance against individual allergens, is the approach to treat the underlying mechanisms of these two interrelated respiratory diseases. Some trials have been published focusing primarily on the effect of AIT on parameters of allergic asthma. Here we give a summary of the evidence for the efficacy of AIT in the indication of allergic asthma.
Identifiants
pubmed: 36925993
doi: 10.5414/ALX02332E
pmc: PMC10012881
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
33-38Informations de copyright
© Dustri-Verlag Dr. K. Feistle.
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