Postoperative jaundice related to
Case report
Cholestasis
Intrahepatic bile duct stones
Postoperative jaundice
Uridine 5’-diphospho-glucuronosyltransferase 1A1
adenosine triphosphate-binding cassette subfamily B member 11
Journal
World journal of clinical cases
ISSN: 2307-8960
Titre abrégé: World J Clin Cases
Pays: United States
ID NLM: 101618806
Informations de publication
Date de publication:
26 Feb 2023
26 Feb 2023
Historique:
received:
08
11
2022
revised:
07
12
2022
accepted:
02
02
2023
entrez:
17
3
2023
pubmed:
18
3
2023
medline:
18
3
2023
Statut:
ppublish
Résumé
Patients with obstructive jaundice caused by intrahepatic bile duct stones can be effectively managed by surgery. However, some patients may develop postoperative complications, liver failure, and other life-threatening situations. Here, we report a patient with mutations in the uridine 5'-diphospho-glucuronosyltransferase 1A1 ( A 52-year-old male patient admitted to the hospital on October 23, 2021, with a progressive exacerbation of jaundice, was found to have multiple intrahepatic bile duct stones with the diagnoses of obstructive jaundice and acute cholecystitis. Subsequently, the patient underwent left hepatectomy with biliary exploration, stone extraction, T-tube drainage, and cholecystectomy without developing any intraoperative complications. The patient had a dark urine color with worsening jaundice postoperatively and did not respond well to plasma exchange and other symptomatic and supportive treatments. Since the progressive increase in postoperative bilirubin could not be clinically explained with any potential reason, including, if not at all, viral infection, cholangitis, autoimmune liver disease, and other causes, the patient underwent whole-exon screening for any genetic diseases, which surprisingly identified Surgery may aggravate cholestasis in patients with multiple intrahepatic bile duct stones and cholestasis associated with
Sections du résumé
BACKGROUND
BACKGROUND
Patients with obstructive jaundice caused by intrahepatic bile duct stones can be effectively managed by surgery. However, some patients may develop postoperative complications, liver failure, and other life-threatening situations. Here, we report a patient with mutations in the uridine 5'-diphospho-glucuronosyltransferase 1A1 (
CASE SUMMARY
METHODS
A 52-year-old male patient admitted to the hospital on October 23, 2021, with a progressive exacerbation of jaundice, was found to have multiple intrahepatic bile duct stones with the diagnoses of obstructive jaundice and acute cholecystitis. Subsequently, the patient underwent left hepatectomy with biliary exploration, stone extraction, T-tube drainage, and cholecystectomy without developing any intraoperative complications. The patient had a dark urine color with worsening jaundice postoperatively and did not respond well to plasma exchange and other symptomatic and supportive treatments. Since the progressive increase in postoperative bilirubin could not be clinically explained with any potential reason, including, if not at all, viral infection, cholangitis, autoimmune liver disease, and other causes, the patient underwent whole-exon screening for any genetic diseases, which surprisingly identified
CONCLUSION
CONCLUSIONS
Surgery may aggravate cholestasis in patients with multiple intrahepatic bile duct stones and cholestasis associated with
Identifiants
pubmed: 36926131
doi: 10.12998/wjcc.v11.i6.1393
pmc: PMC10013108
doi:
Types de publication
Case Reports
Langues
eng
Pagination
1393-1402Informations de copyright
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
Déclaration de conflit d'intérêts
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Références
World J Surg. 2017 Mar;41(3):835-843
pubmed: 27766397
Ann Hepatol. 2017 May - Jun 2017;16(3):465-468
pubmed: 28425419
Dig Dis Sci. 2016 Aug;61(8):2226-2230
pubmed: 26518416
Clin Res Hepatol Gastroenterol. 2017 Feb;41(1):39-45
pubmed: 27542514
Hepatology. 2006 Jul;44(1):62-74
pubmed: 16799996
Intern Med. 2017;56(6):661-664
pubmed: 28321066
World J Gastroenterol. 2015 Feb 21;21(7):2169-77
pubmed: 25717253
Hepatology. 2005 May;41(5):1160-72
pubmed: 15841457
Pediatr Res. 2016 Mar;79(3):378-86
pubmed: 26595536
Drug Discov Today Technol. 2014 Jun;12:e55-67
pubmed: 25027376
Tech Vasc Interv Radiol. 2015 Dec;18(4):197-200
pubmed: 26615159
Hepatol Res. 2016 Feb;46(2):192-200
pubmed: 26223708
Can J Gastroenterol Hepatol. 2019 Dec 10;2019:1085717
pubmed: 31886153
Clin Liver Dis. 2002 Nov;6(4):1067-84
pubmed: 12516207
Liver Transpl. 2017 Sep;23(9):1229-1232
pubmed: 28524363
Adv Pharmacol. 2015;74:263-302
pubmed: 26233910
Gastroenterol Res Pract. 2017;2017:7213043
pubmed: 28163717
Intractable Rare Dis Res. 2017 May;6(2):102-105
pubmed: 28580209
Blood Coagul Fibrinolysis. 2016 Mar;27(2):226-7
pubmed: 26569514
Hepatology. 2006 Oct;44(4):778-87
pubmed: 17006912
Rev Bras Ter Intensiva. 2016 Oct-Dec;28(4):463-471
pubmed: 28099643
J Pediatr. 1989 Aug;115(2):291-5
pubmed: 2666628
Dig Liver Dis. 2013 Mar;45(3):226-32
pubmed: 23022423
Sci Rep. 2016 Jun 13;6:27750
pubmed: 27293027
Clin Liver Dis. 2008 Feb;12(1):1-26, vii
pubmed: 18242495
Annu Rev Biochem. 2002;71:537-92
pubmed: 12045106
Curr Gastroenterol Rep. 2020 May 7;22(6):30
pubmed: 32383039
Biochem Biophys Res Commun. 1993 Dec 30;197(3):1239-44
pubmed: 8280139
Nihon Geka Gakkai Zasshi. 2004 Oct;105(10):664-8
pubmed: 15521383
J Gastroenterol Hepatol. 2016 Feb;31(2):403-8
pubmed: 26250421
Cytogenet Cell Genet. 1993;63(2):114-6
pubmed: 8467709
Liver Int. 2012 Jan;32(1):119-27
pubmed: 22098322
J Hepatol. 2013 Nov;59(5):1094-106
pubmed: 23811302