Synthesis and Preclinical Evaluation of a Novel Fluorine-18-Labeled Tracer for Positron Emission Tomography Imaging of Bruton's Tyrosine Kinase.


Journal

ACS pharmacology & translational science
ISSN: 2575-9108
Titre abrégé: ACS Pharmacol Transl Sci
Pays: United States
ID NLM: 101721411

Informations de publication

Date de publication:
10 Mar 2023
Historique:
received: 05 11 2022
pmc-release: 10 02 2024
entrez: 17 3 2023
pubmed: 18 3 2023
medline: 18 3 2023
Statut: epublish

Résumé

Bruton's tyrosine kinase (BTK) is a target for treating B-cell malignancies and autoimmune diseases. To aid in the discovery and development of BTK inhibitors and improve clinical diagnoses, we have developed a positron emission tomography (PET) radiotracer based on a selective BTK inhibitor, remibrutinib. [

Identifiants

pubmed: 36926452
doi: 10.1021/acsptsci.2c00215
pmc: PMC10012250
doi:

Types de publication

Journal Article

Langues

eng

Pagination

410-421

Subventions

Organisme : NIBIB NIH HHS
ID : R01 EB024549
Pays : United States
Organisme : NIBIB NIH HHS
ID : R41 EB029860
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM127253
Pays : United States

Informations de copyright

© 2023 American Chemical Society.

Déclaration de conflit d'intérêts

The authors declare the following competing financial interest(s): P.J.T. is the co-founder of Chronus Pharmaceuticals Inc.

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Auteurs

Kaixuan Li (K)

Center for Advanced Study of Drug Action and Department of Chemistry, Stony Brook University, John S. Toll Drive, Stony Brook, New York 11794-3400, United States.
Center for Advanced Study of Drug Action and Department of Chemistry, Stony Brook University, John S. Toll Drive, Stony Brook, New York 11794-3400, United States.

Mingqian Wang (M)

Center for Advanced Study of Drug Action and Department of Chemistry, Stony Brook University, John S. Toll Drive, Stony Brook, New York 11794-3400, United States.
Center for Advanced Study of Drug Action and Department of Chemistry, Stony Brook University, John S. Toll Drive, Stony Brook, New York 11794-3400, United States.

Melike Akoglu (M)

Center for Advanced Study of Drug Action and Department of Chemistry, Stony Brook University, John S. Toll Drive, Stony Brook, New York 11794-3400, United States.
Center for Advanced Study of Drug Action and Department of Chemistry, Stony Brook University, John S. Toll Drive, Stony Brook, New York 11794-3400, United States.

Alyssa C Pollard (AC)

Center for Advanced Study of Drug Action and Department of Chemistry, Stony Brook University, John S. Toll Drive, Stony Brook, New York 11794-3400, United States.
Center for Advanced Study of Drug Action and Department of Chemistry, Stony Brook University, John S. Toll Drive, Stony Brook, New York 11794-3400, United States.

John B Klecker (JB)

Center for Advanced Study of Drug Action and Department of Chemistry, Stony Brook University, John S. Toll Drive, Stony Brook, New York 11794-3400, United States.
Center for Advanced Study of Drug Action and Department of Chemistry, Stony Brook University, John S. Toll Drive, Stony Brook, New York 11794-3400, United States.

Patricia Alfonso (P)

Enzymlogic S.L., QUBE Technology Park, C/Santiago Grisolía, 2, 28760 Madrid, Spain.

Ana Corrionero (A)

Enzymlogic S.L., QUBE Technology Park, C/Santiago Grisolía, 2, 28760 Madrid, Spain.

Niall Prendiville (N)

Enzymlogic S.L., QUBE Technology Park, C/Santiago Grisolía, 2, 28760 Madrid, Spain.

Wenchao Qu (W)

Department of Psychiatry, Department of Radiology, Department of Medicine, Stony Brook Cancer Center, and Facility of Experimental Radiopharmaceutical Manufacturing (FERM), Stony Brook Renaissance School of Medicine, Stony Brook University, Stony Brook, New York 11794, United States.
Department of Psychiatry, Department of Radiology, Department of Medicine, Stony Brook Cancer Center, and Facility of Experimental Radiopharmaceutical Manufacturing (FERM), Stony Brook Renaissance School of Medicine, Stony Brook University, Stony Brook, New York 11794, United States.
Center for Advanced Study of Drug Action and Department of Chemistry, Stony Brook University, John S. Toll Drive, Stony Brook, New York 11794-3400, United States.

Matthew F L Parker (MFL)

Department of Psychiatry, Department of Radiology, Department of Medicine, Stony Brook Cancer Center, and Facility of Experimental Radiopharmaceutical Manufacturing (FERM), Stony Brook Renaissance School of Medicine, Stony Brook University, Stony Brook, New York 11794, United States.
Center for Advanced Study of Drug Action and Department of Chemistry, Stony Brook University, John S. Toll Drive, Stony Brook, New York 11794-3400, United States.

Nashaat Turkman (N)

Department of Psychiatry, Department of Radiology, Department of Medicine, Stony Brook Cancer Center, and Facility of Experimental Radiopharmaceutical Manufacturing (FERM), Stony Brook Renaissance School of Medicine, Stony Brook University, Stony Brook, New York 11794, United States.
Department of Psychiatry, Department of Radiology, Department of Medicine, Stony Brook Cancer Center, and Facility of Experimental Radiopharmaceutical Manufacturing (FERM), Stony Brook Renaissance School of Medicine, Stony Brook University, Stony Brook, New York 11794, United States.

Jules A Cohen (JA)

Department of Psychiatry, Department of Radiology, Department of Medicine, Stony Brook Cancer Center, and Facility of Experimental Radiopharmaceutical Manufacturing (FERM), Stony Brook Renaissance School of Medicine, Stony Brook University, Stony Brook, New York 11794, United States.
Department of Psychiatry, Department of Radiology, Department of Medicine, Stony Brook Cancer Center, and Facility of Experimental Radiopharmaceutical Manufacturing (FERM), Stony Brook Renaissance School of Medicine, Stony Brook University, Stony Brook, New York 11794, United States.

Peter J Tonge (PJ)

Center for Advanced Study of Drug Action and Department of Chemistry, Stony Brook University, John S. Toll Drive, Stony Brook, New York 11794-3400, United States.
Department of Psychiatry, Department of Radiology, Department of Medicine, Stony Brook Cancer Center, and Facility of Experimental Radiopharmaceutical Manufacturing (FERM), Stony Brook Renaissance School of Medicine, Stony Brook University, Stony Brook, New York 11794, United States.
Center for Advanced Study of Drug Action and Department of Chemistry, Stony Brook University, John S. Toll Drive, Stony Brook, New York 11794-3400, United States.
Department of Psychiatry, Department of Radiology, Department of Medicine, Stony Brook Cancer Center, and Facility of Experimental Radiopharmaceutical Manufacturing (FERM), Stony Brook Renaissance School of Medicine, Stony Brook University, Stony Brook, New York 11794, United States.

Classifications MeSH