Longevity, tumor, and physical vitality in rats consuming ginsenoside Rg1.
Dual-energy x-ray absorptiometry, (DEXA)
Ginseng
High-fructose corn syrup, (HFCS)
IL-10
Inflammation
Institutional Animal Care and Use Committee, (IACUC)
Interleukin-10, (IL-10)
Muscle mass
Obesity
Oxidized LDL
Oxidized low density lipoprotein, (oxidized LDL)
Standard error, (SE)
TNF-α
Tumor necrosis factor-α, (TNF-α)
Two-way analysis of variance, (ANOVA)
Journal
Journal of ginseng research
ISSN: 1226-8453
Titre abrégé: J Ginseng Res
Pays: Korea (South)
ID NLM: 100890690
Informations de publication
Date de publication:
Mar 2023
Mar 2023
Historique:
received:
30
11
2020
revised:
12
03
2021
accepted:
18
04
2021
entrez:
17
3
2023
pubmed:
18
3
2023
medline:
18
3
2023
Statut:
ppublish
Résumé
Effects of the major ginsenoside Rg1 on mammalian longevity and physical vitality are rarely reported. To examine longevity, tumor, and spontaneous locomotor activity in rats consuming Rg1. A total of 138 Wistar rats were randomized into 2 groups: control (N = 69) and Rg1 (N = 69). Rg1 (0.1 mg/kg per day) were orally supplemented from 6 months of age until natural death. Spontaneous mobility was measured by video-tracking together with body composition (dual energy x-ray absorptiometry) and inflammation markers at 5, 14, 21, and 28 months of age. No significant differences in longevity (control: 706 days; Rg1: 651 days, The results of the study suggest a delay age-dependent decline in physical vitality during late life by lifelong Rg1 consumption. This improvement is associated with inflammatory modulation. Significant effects of Rg1 on longevity and tumorigenesis were not observed.
Sections du résumé
Background
UNASSIGNED
Effects of the major ginsenoside Rg1 on mammalian longevity and physical vitality are rarely reported.
Purpose
UNASSIGNED
To examine longevity, tumor, and spontaneous locomotor activity in rats consuming Rg1.
Methods
UNASSIGNED
A total of 138 Wistar rats were randomized into 2 groups: control (N = 69) and Rg1 (N = 69). Rg1 (0.1 mg/kg per day) were orally supplemented from 6 months of age until natural death. Spontaneous mobility was measured by video-tracking together with body composition (dual energy x-ray absorptiometry) and inflammation markers at 5, 14, 21, and 28 months of age.
Results
UNASSIGNED
No significant differences in longevity (control: 706 days; Rg1: 651 days,
Conclusion
UNASSIGNED
The results of the study suggest a delay age-dependent decline in physical vitality during late life by lifelong Rg1 consumption. This improvement is associated with inflammatory modulation. Significant effects of Rg1 on longevity and tumorigenesis were not observed.
Identifiants
pubmed: 36926614
doi: 10.1016/j.jgr.2021.04.006
pii: S1226-8453(21)00048-8
pmc: PMC10014179
doi:
Types de publication
Journal Article
Langues
eng
Pagination
210-217Informations de copyright
© 2021 The Korean Society of Ginseng. Publishing services by Elsevier B.V.
Déclaration de conflit d'intérêts
CHK and JFW are involved with US patents (10,806,764 B2) for an anti-aging method. This work was funded leading to a designed supplement Senactiv for Nuliv Science, USA.
Références
Proc Natl Acad Sci U S A. 2012 Jan 31;109(5):1595-600
pubmed: 22307617
Sci Adv. 2020 Jul 29;6(31):eabb0806
pubmed: 32832688
Circulation. 2004 Sep 7;110(10):1219-25
pubmed: 15337705
Drug Chem Toxicol. 2001 Nov;24(4):315-38
pubmed: 11665646
Int J Mol Med. 2017 Oct;40(4):1134-1142
pubmed: 28849171
Basic Res Cardiol. 2017 May;112(3):33
pubmed: 28439731
Curr Pharm Des. 2010;16(6):584-96
pubmed: 20388068
Int J Obes Relat Metab Disord. 2004 Nov;28 Suppl 3:S59-63
pubmed: 15543221
FASEB J. 2019 Sep;33(9):10353-10368
pubmed: 31208207
Br J Pharmacol. 2012 Jul;166(6):1872-87
pubmed: 22335772
Sci Rep. 2017 Feb 20;7:42791
pubmed: 28216665
Eur J Clin Nutr. 2003 Feb;57(2):243-8
pubmed: 12571655
Eur J Pharmacol. 2015 Sep 5;762:333-43
pubmed: 26054809
J Ginseng Res. 2019 Oct;43(4):580-588
pubmed: 31695564
Pharmacology. 2015;96(1-2):25-31
pubmed: 26065578
BMJ. 2009 Mar 05;338:b688
pubmed: 19264819
JNCI Cancer Spectr. 2019 Aug 09;3(4):pkz054
pubmed: 31737862
Gerontology. 1979;25(3):125-31
pubmed: 571386
J Ginseng Res. 2019 Jul;43(3):354-360
pubmed: 31308806
Chin J Physiol. 2019 Nov-Dec;62(6):267-272
pubmed: 31793463
Trends Immunol. 2015 Apr;36(4):217-28
pubmed: 25801910
J Am Coll Nutr. 2004 Jun;23(3):248-58
pubmed: 15190050
Diabetes. 2016 Jun;65(6):1606-15
pubmed: 26983960
J Appl Physiol (1985). 2008 Apr;104(4):991-7
pubmed: 18218915
J Complement Integr Med. 2011 Jan;8:
pubmed: 22754952
Nutrients. 2018 Jun 27;10(7):
pubmed: 29954059
Aging Cell. 2015 Aug;14(4):678-88
pubmed: 26009878
Nat Rev Immunol. 2017 Mar;17(3):165-178
pubmed: 28163303
Antioxidants (Basel). 2017 May 19;6(2):
pubmed: 28534811