History of infertility and risk of breast cancer: a prospective cohort study.
Age at first birth
Breast cancer
Infertility
Parity
Journal
Breast cancer research and treatment
ISSN: 1573-7217
Titre abrégé: Breast Cancer Res Treat
Pays: Netherlands
ID NLM: 8111104
Informations de publication
Date de publication:
May 2023
May 2023
Historique:
received:
04
01
2023
accepted:
24
02
2023
pmc-release:
01
05
2024
medline:
1
5
2023
pubmed:
18
3
2023
entrez:
17
3
2023
Statut:
ppublish
Résumé
Research on infertility and risk of breast cancer has been conflicting, potentially because many well-established breast cancer risk factors, such as pregnancy history, are strongly correlated with infertility. We followed participants in the Nurses' Health Study II from 1989 to 2015 (n = 103,080) for the development of invasive breast cancer and calculated Hazard Ratios (HR) and 95% confidence intervals (CI) using Cox regression. Participants with a self-reported history of infertility (12 months of trying without conception) were compared to gravid women with no history of infertility. We classified breast cancer by menopausal status and investigated mediation by reproductive factors. Over 26 years of follow-up, 26,208 (25.4%) women reported a history of infertility, and 3,201 women were newly diagnosed with invasive breast cancer. We observed no association between infertility history and risk of overall breast cancer (HR: 1.05, 95% CI: 0.97-1.14) or premenopausal breast cancer (RR: 0.93, 95% CI: 0.83-1.03). However, we observed a modest association between history of infertility and risk of postmenopausal breast cancer (HR: 1.13, 95% CI: 1.00-1.28), approximately 50% of which could be attributed to lower total parity and later age at first birth (95% CI: 8.2%-91.0%). Women with a history of infertility were at increased risk of postmenopausal breast cancer. Older age at first birth and lower total parity explained approximately half of the association between infertility and risk of postmenopausal breast cancer.
Identifiants
pubmed: 36928623
doi: 10.1007/s10549-023-06907-1
pii: 10.1007/s10549-023-06907-1
pmc: PMC10695171
mid: NIHMS1925224
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
185-193Subventions
Organisme : NICHD NIH HHS
ID : R01 HD096033
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA176726
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL145386
Pays : United States
Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
Références
Am J Obstet Gynecol. 1994 Jul;171(1):171-7
pubmed: 8030695
JAMA. 2016 Jul 19;316(3):300-12
pubmed: 27434442
Hum Reprod Update. 2021 Feb 19;27(2):393-420
pubmed: 33202017
Am J Epidemiol. 1994 Apr 15;139(8):819-35
pubmed: 8178795
Epidemiology. 2011 Jul;22(4):582-5
pubmed: 21642779
J Cancer Res Ther. 2019 Jul-Sep;15(5):976-980
pubmed: 31603097
Hum Reprod. 2021 Apr 20;36(5):1268-1278
pubmed: 33595055
Lancet Reg Health Am. 2022 Mar;7:
pubmed: 35419553
Am J Public Health. 2016 Sep;106(9):1669-76
pubmed: 27459445
Fertil Steril. 2017 Sep;108(3):393-406
pubmed: 28760517
Am J Epidemiol. 2013 Jul 15;178(2):296-308
pubmed: 23645624
J Mammary Gland Biol Neoplasia. 2002 Jan;7(1):3-15
pubmed: 12160084
Am J Public Health. 2016 Sep;106(9):1624-30
pubmed: 27459454
Breast Cancer Res. 2013;15(4):R68
pubmed: 23971947
Cancer Epidemiol Biomarkers Prev. 2017 Jun;26(6):953-962
pubmed: 28108444
Semin Reprod Med. 2012 Apr;30(2):131-45
pubmed: 22549713
J Assist Reprod Genet. 2017 Feb;34(2):167-177
pubmed: 27817040
Eur J Epidemiol. 2019 May;34(5):499-507
pubmed: 30623293
Int J Epidemiol. 1993 Dec;22(6):1000-9
pubmed: 8144280
Am J Epidemiol. 2008 Jul 1;168(1):49-57
pubmed: 18448441
Epidemiology. 2005 Jul;16(4):500-7
pubmed: 15951668
Ann Intern Med. 2019 Jan 1;170(1):22-30
pubmed: 30534999
Fertil Steril. 2021 Jul;116(1):198-207
pubmed: 34148584
J Natl Cancer Inst. 2012 Jul 3;104(13):1021-7
pubmed: 22773825
Obstet Gynecol. 2016 Nov;128(5):1025-1031
pubmed: 27741204
Cancer Treat Rev. 2016 Sep;49:65-76
pubmed: 27529149
Br J Cancer. 2009 Feb 10;100(3):538-44
pubmed: 19190634
Am J Obstet Gynecol. 1997 Mar;176(3):572-9
pubmed: 9077609
Hum Reprod. 2020 Jun 1;35(6):1262-1266
pubmed: 32424401