A beta cell subset with enhanced insulin secretion and glucose metabolism is reduced in type 2 diabetes.
Journal
Nature cell biology
ISSN: 1476-4679
Titre abrégé: Nat Cell Biol
Pays: England
ID NLM: 100890575
Informations de publication
Date de publication:
04 2023
04 2023
Historique:
received:
11
05
2022
accepted:
02
02
2023
medline:
18
4
2023
pubmed:
18
3
2023
entrez:
17
3
2023
Statut:
ppublish
Résumé
The pancreatic islets are composed of discrete hormone-producing cells that orchestrate systemic glucose homeostasis. Here we identify subsets of beta cells using a single-cell transcriptomic approach. One subset of beta cells marked by high CD63 expression is enriched for the expression of mitochondrial metabolism genes and exhibits higher mitochondrial respiration compared with CD63
Identifiants
pubmed: 36928765
doi: 10.1038/s41556-023-01103-1
pii: 10.1038/s41556-023-01103-1
pmc: PMC10449536
mid: NIHMS1921036
doi:
Substances chimiques
Insulin
0
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
565-578Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK121140
Pays : United States
Organisme : NIDDK NIH HHS
ID : U24 DK098085
Pays : United States
Organisme : NIDDK NIH HHS
ID : R37 DK048873
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK121844
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK063608
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK056626
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK112217
Pays : United States
Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer Nature Limited.
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