Paradoxical Reactions to Anti-TNFα and Anti-IL-17 Treatment in Psoriasis Patients: Are Skin and/or Gut Microbiota Involved?

Biologics Gut microbiota Gut–skin axis IBD IL-17 Psoriasis Skin adverse events Skin microbiota TNFα

Journal

Dermatology and therapy
ISSN: 2193-8210
Titre abrégé: Dermatol Ther (Heidelb)
Pays: Switzerland
ID NLM: 101590450

Informations de publication

Date de publication:
Apr 2023
Historique:
received: 25 10 2022
accepted: 14 02 2023
medline: 18 3 2023
pubmed: 18 3 2023
entrez: 17 3 2023
Statut: ppublish

Résumé

Psoriasis is a chronic, immune-mediated, inflammatory disease primarily affecting the skin. It is currently coming to light that patients with psoriasis have disrupted intestinal barrier and often suffer from comorbidities associated with the gastrointestinal tract. Moreover, there is growing evidence of both cutaneous and intestinal paradoxical reactions during biologic treatment in patients with psoriasis. This review focuses on barrier defects and changes in immune responses in patients with psoriasis, which play an important role in the development of the disease but are also influenced by modern biological treatments targeting IL-17 and TNFα cytokines. Here, we highlight the relationship between the gut-skin axis, microbiota, psoriasis treatment, and the incidence of paradoxical reactions, such as inflammatory bowel disease in patients with psoriasis. A better understanding of the interconnection of these mechanisms could lead to a more personalized therapy and lower the incidence of treatment side effects, thereby improving the quality of life of the affected patients.

Identifiants

pubmed: 36929119
doi: 10.1007/s13555-023-00904-4
pii: 10.1007/s13555-023-00904-4
pmc: PMC10060503
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

911-933

Subventions

Organisme : Ministerstvo Zdravotnictví Ceské Republiky
ID : NV18-09-00493
Organisme : Ministerstvo Zdravotnictví Ceské Republiky
ID : NU22J-05-00056
Organisme : Ministerstvo Zdravotnictví Ceské Republiky
ID : NU22-01-00077
Organisme : Institutional Research Concept
ID : RVO: 61388971

Informations de copyright

© 2023. The Author(s).

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Auteurs

Zuzana Jiraskova Zakostelska (Z)

Institute of Microbiology of the Czech Academy of Sciences, Videnska 1083, 14220, Prague, Czech Republic. zakostelska@biomed.cas.cz.

Zuzana Reiss (Z)

Institute of Microbiology of the Czech Academy of Sciences, Videnska 1083, 14220, Prague, Czech Republic.

Helena Tlaskalova-Hogenova (H)

Institute of Microbiology of the Czech Academy of Sciences, Videnska 1083, 14220, Prague, Czech Republic.

Filip Rob (F)

Department of Dermatovenerology, Second Faculty of Medicine, Charles University, Bulovka University Hospital, Prague, Czech Republic.

Classifications MeSH