Healthy preterm newborns: Altered innate immunity and impaired monocyte function.
Cytokines
Inflammasomes
Inflammation
Monocytes
Preterm births
Journal
European journal of immunology
ISSN: 1521-4141
Titre abrégé: Eur J Immunol
Pays: Germany
ID NLM: 1273201
Informations de publication
Date de publication:
05 2023
05 2023
Historique:
revised:
14
02
2023
received:
19
10
2022
accepted:
13
03
2023
medline:
19
5
2023
pubmed:
18
3
2023
entrez:
17
3
2023
Statut:
ppublish
Résumé
Birth prior to 37 completed weeks of gestation is referred to as preterm (PT). Premature newborns are at increased risk of developing infections as neonatal immunity is a developing structure. Monocytes, which are key players after birth, activate inflammasomes. Investigations into the identification of innate immune profiles in premature compared to full-term infants are limited. Our research includes the investigation of monocytes and NK cells, gene expression, and plasma cytokine levels to investigate any potential differences among a cohort of 68 healthy PT and full-term infants. According to high-dimensional flow cytometry, PT infants have higher proportions of CD56
Identifiants
pubmed: 36929362
doi: 10.1002/eji.202250224
doi:
Substances chimiques
Cytokines
0
Inflammasomes
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2250224Informations de copyright
© 2023 The Authors. European Journal of Immunology published by Wiley-VCH GmbH.
Références
Busse, M., Redlich, A., Hartig, R., Costa, S. D., Rathert, H., Fest, S. and Zenclussen, A. C., Imbalance between inflammatory and regulatory cord blood B cells following pre-term birth. J. Reprod. Immunol. 2021. 145: 103319.
Fang, X., Wang, Y., Zhang, Y., Li, Y., Kwak-Kim, J. and Wu, L., NLRP3 inflammasome and its critical role in gynecological disorders and obstetrical complications. Front. Immunol. 2020. 11: 555826.
Liu, L., Oza, S., Hogan, D., Chu, Y., Perin, J., Zhu, J., Lawn, J. E. et al., Global, regional, and national causes of under-5 mortality in 2000-15: an updated systematic analysis with implications for the sustainable development goals. Lancet 2016. 388: 3027-3035.
Walani, S. R., Global burden of preterm birth. Int. J. Gynaecol. Obstet. 2020. 150: 31-33.
Altman, M., Vanpee, M., Cnattingius, S. and Norman, M., Moderately preterm infants and determinants of length of hospital stay. Arch. Dis. Child. Fetal Neonatal Ed. 2009. 94: F414-418.
Berardi, A., Sforza, F., Baroni, L., Spada, C., Ambretti, S., Biasucci, G., Bolognesi, S. et al., Epidemiology and complications of late-onset sepsis: an Italian area-based study. PLoS One 2019. 14: e0225407.
de Jong, E., Strunk, T., Burgner, D., Lavoie, P. M. and Currie, A., The phenotype and function of preterm infant monocytes: implications for susceptibility to infection. J. Leukoc. Biol. 2017. 102: 645-656.
Tsafaras, G. P., Ntontsi, P. and Xanthou, G., Advantages and limitations of the neonatal immune system. Front. Pediatr. 2020. 8: 5.
Yu, J. C., Khodadadi, H., Malik, A., Davidson, B., Salles, E., Bhatia, J., Hale, V. L. et al., Innate immunity of neonates and infants. Front. Immunol. 2018. 9: 1759.
Zasada, M., Lenart, M., Rutkowska-Zapala, M., Stec, M., Mol, N., Czyz, O., Siedlar, M et al., Analysis of selected aspects of inflammasome function in the monocytes from neonates born extremely and very prematurely. Immunobiology 2018. 223: 18-24.
Anderson, J., Thang, C. M., Thanh, L. Q., Dai, V. T. T., Phan, V. T., Nhu, B. T. H., Trang, D.N. X. et al., Immune profiling of cord blood from preterm and term infants reveals distinct differences in pro-inflammatory responses. Front. Immunol. 2021. 12: 777927.
Perez, A., Gurbindo, M. D., Resino, S., Aguaron, A. and Munoz-Fernandez, M. A., NK cell increase in neonates from the preterm to the full-term period of gestation. Neonatology 2007. 92: 158-163.
Ulas, T., Pirr, S., Fehlhaber, B., Bickes, M. S., Loof, T. G., Vogl, T., Mellinger, L et al., S100- alarmin-induced innate immune programming protects newborn infants from sepsis. Nat. Immunol. 2017. 18: 622-632.
Kollmann, T. R., Kampmann, B., Mazmanian, S. K., Marchant, A. and Levy, O., Protecting the newborn and young infant from infectious diseases: lessons from immune ontogeny. Immunity 2017. 46: 350-363.
Gibellini, L., De Biasi, S., Paolini, A., Borella, R., Boraldi, F., Mattioli, M., Lo Tartaro, D.et al., Altered bioenergetics and mitochondrial dysfunction of monocytes in patients with COVID-19 pneumonia. EMBO Mol. Med. 2020. 12: e13001.
Maffei, R., Bulgarelli, J., Fiorcari, S., Bertoncelli, L., Martinelli, S., Guarnotta, C., Castelli, I. et al., The monocytic population in chronic lymphocytic leukemia shows altered composition and deregulation of genes involved in phagocytosis and inflammation. Haematologica 2013. 98: 1115-1123.
Nasi, M., Pecorini, S., De Biasi, S., Bianchini, E., Digaetano, M., Neroni, A., Lo Tartaro, D. et al., Altered expression of PYCARD, interleukin 1beta, interleukin 18, and NAIP in successfully treated HIV-positive patients with a low ratio of CD4+ to CD8+ T cells. J. Infect. Dis. 2019. 219: 1743-1748.
Khan, R. N. and Hay, D. P., A clear and present danger: inflammasomes DAMPing down disorders of pregnancy. Hum. Reprod. Update 2015. 21: 388-405.
Liao, J., Kapadia, V. S., Brown, L. S., Cheong, N., Longoria, C., Mija, D., Ramgopal, M. et al., The NLRP3 inflammasome is critically involved in the development of bronchopulmonary dysplasia. Nat. Commun. 2015. 6: 8977.
Stouch, A. N., McCoy, A. M., Greer, R. M., Lakhdari, O., Yull, F. E., Blackwell, T. S., Hoffman, H. M. et al., IL-1beta and inflammasome activity link inflammation to abnormal fetal airway development. J. Immunol. 2016. 196: 3411-3420.
Chatterjee, P., Chiasson, V. L., Bounds, K. R. and Mitchell, B. M., Regulation of the anti- inflammatory cytokines interleukin-4 and interleukin-10 during pregnancy. Front. Immunol. 2014. 5: 253.
Webster, N. L. and Crowe, S. M., Matrix metalloproteinases, their production by monocytes and macrophages and their potential role in HIV-related diseases. J. Leukoc. Biol. 2006. 80: 1052-1066.
Cao, C., Gu, J. and Zhang, J., Soluble triggering receptor expressed on myeloid cell-1 (sTREM-1): a potential biomarker for the diagnosis of infectious diseases. Front. Med. 2017. 11: 169-177.
Gomez-Pina, V., Soares-Schanoski, A., Rodriguez-Rojas, A., Del Fresno, C., Garcia, F., Vallejo-Cremades, M. T., Fernandez-Ruiz, I. et al., Metalloproteinases shed TREM-1 ectodomain from lipopolysaccharide-stimulated human monocytes. J. Immunol. 2007. 179: 4065-4073.
Crowe, L. A. N., McLean, M., Kitson, S. M., Melchor, E. G., Patommel, K., Cao, H. M., Reilly, J. H. et al., S100A8 & S100A9: alarmin mediated inflammation in tendinopathy. Sci. Rep. 2019. 9: 1463.
Lo Tartaro, D., Neroni, A., Paolini, A., Borella, R., Mattioli, M., Fidanza, L., Quong, A. et al., Molecular and cellular immune features of aged patients with severe COVID-19 pneumonia. Commun. Biol. 2022. 5: 590.
Cossarizza, A., Chang, H. D., Radbruch, A., Acs, A., Adam, D., Adam-Klages, S., Agace, W. W. et al., Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition). Eur. J. Immunol. 2019. 49: 1457-1973.
Poli, A., Michel, T., Theresine, M., Andres, E., Hentges, F. and Zimmer, J., CD56bright natural killer (NK) cells: an important NK cell subset. Immunology 2009. 126: 458-465.
Gaddy, J. and Broxmeyer, H. E., Cord blood CD16+56- cells with low lytic activity are possible precursors of mature natural killer cells. Cell. Immunol. 1997. 180: 132-142.
Gaddy, J., Risdon, G. and Broxmeyer, H. E., Cord blood natural killer cells are functionally and phenotypically immature but readily respond to interleukin-2 and interleukin-12. J. Interferon Cytokine Res. 1995. 15: 527-536.
Alter, G., Teigen, N., Davis, B. T., Addo, M. M., Suscovich, T. J., Waring, M. T., Streeck, H. et al., Sequential deregulation of NK cell subset distribution and function starting in acute HIV-1 infection. Blood 2005. 106: 3366-3369.
Mavilio, D., Lombardo, G., Benjamin, J., Kim, D., Follman, D., Marcenaro, E., O'Shea, M. A. et al., Characterization of CD56-/CD16+ natural killer (NK) cells: a highly dysfunctional NK subset expanded in HIV-infected viremic individuals. Proc. Natl. Acad. Sci. USA. 2005. 102: 2886-2891.
De Maria, A., Bozzano, F., Cantoni, C. and Moretta, L., Revisiting human natural killer cell subset function revealed cytolytic CD56(dim)CD16+ NK cells as rapid producers of abundant IFN-gamma on activation. Proc. Natl. Acad. Sci. USA. 2011. 108: 728-732.
Riva, G., Castellano, S., Nasillo, V., Ottomano, A. M., Bergonzini, G., Paolini, A., Lusenti, B. et al., Monocyte distribution width (MDW) as novel inflammatory marker with prognostic significance in COVID-19 patients. Sci. Rep. 2021. 11: 12716.
Nakamori, Y., Park, E. J. and Shimaoka, M., Immune deregulation in sepsis and septic shock: reversing immune paralysis by targeting PD-1/PD-L1 pathway. Front. Immunol. 2020. 11: 624279.
Huang, Y., Xu, W. and Zhou, R., NLRP3 inflammasome activation and cell death. Cell. Mol. Immunol. 2021. 18: 2114-2127.
Paolini, A., Borella, R., De Biasi, S., Neroni, A., Mattioli, M., Lo Tartaro, D., Simonini, C. et al., Cell death in coronavirus infections: uncovering its role during COVID-19. Cells 2021. 10: 1585.
Bauer, R. and Rauch, I., The NAIP/NLRC4 inflammasome in infection and pathology. Mol. Aspects Med. 2020. 76: 100863.
Kumari, P., Russo, A. J., Shivcharan, S. and Rathinam, V. A., AIM2 in health and disease: inflammasome and beyond. Immunol. Rev. 2020. 297: 83-95.
Kay, C., Wang, R., Kirkby, M. and Man, S. M., Molecular mechanisms activating the NAIP- NLRC4 inflammasome: implications in infectious disease, autoinflammation, and cancer. Immunol. Rev. 2020. 297: 67-82.
Yang, Han, Z. and Oppenheim, J. J., Alarmins and immunity. Immunol. Rev. 2017. 280: 41-56.
Vogl, T., Tenbrock, K., Ludwig, S., Leukert, N., Ehrhardt, C., van Zoelen, M. A., Nacken, W. et al., Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock. Nat. Med. 2007. 13: 1042-1049.
Schelbergen, R. F., Geven, E. J., van den Bosch, M. H., Eriksson, H., Leanderson, T., Vogl, T., Roth, J. et al., Prophylactic treatment with S100A9 inhibitor paquinimod reduces pathology in experimental collagenase-induced osteoarthritis. Ann. Rheum. Dis. 2015. 74: 2254-2258.
Pacora, P., Romero, R., Maymon, E., Gervasi, M. T., Gomez, R., Edwin, S. S. and Yoon, B. H., Participation of the novel cytokine interleukin 18 in the host response to intra-amniotic infection. Am. J. Obstet. Gynecol. 2000. 183: 1138-1143.
Reddy, P., Interleukin-18: recent advances. Curr. Opin. Hematol. 2004. 11: 405-410.
Ekelund, C. K., Vogel, I., Skogstrand, K., Thorsen, P., Hougaard, D. M., Langhoff-Roos, J. and Jacobsson, B., Interleukin-18 and interleukin-12 in maternal serum and spontaneous preterm delivery. J. Reprod. Immunol. 2008. 77: 179-185.
Koscica, K. L., Ananth, C. V., Placido, J. and Reznik, S. E., The effect of a matrix metalloproteinase inhibitor on inflammation-mediated preterm delivery. Am. J. Obstet. Gynecol. 2007. 196: 551 e551-553.
De Biasi, S., Meschiari, M., Gibellini, L., Bellinazzi, C., Borella, R., Fidanza, L., Gozzi, L. et al., Marked T cell activation, senescence, exhaustion and skewing towards TH17 in patients with COVID-19 pneumonia. Nat. Commun. 2020. 11: 3434.
Nowicka, M., Krieg, C., Crowell HL., Weber, L. M., Hartmann, F. J., Guglietta, S., Becher, B. et al., CyTOF workflow: differential discovery in high- throughput high-dimensional cytometry datasets. F1000Research 2019. 6: 748.