Etiology and Outcome of Adult and Pediatric Acute Liver Failure in Europe.

Humans Adult Child Liver Failure, Acute / diagnosis Europe / epidemiology Liver Transplantation / adverse effects Chemical and Drug Induced Liver Injury

Journal

Journal of pediatric gastroenterology and nutrition
ISSN: 1536-4801
Titre abrégé: J Pediatr Gastroenterol Nutr
Pays: United States
ID NLM: 8211545

Informations de publication

Date de publication:
01 07 2023
Historique:
medline: 19 6 2023
pubmed: 18 3 2023
entrez: 17 3 2023
Statut: ppublish

Résumé

Acute liver failure (ALF) is rare but life-threatening. Common causes include intoxications, infections, and metabolic disorders. Indeterminate etiology is still frequent. No systematic data on incidence, causes, and outcome of ALF across Europe are available. Via an online survey we reached out to European Reference Network Centers on rare liver diseases. Numbers and etiology of ALF cases during 2020 were retrieved and diagnostic and treatment availabilities assessed. In total, 455 cases (306 adult, 149 pediatric) were reported from 36 centers from 20 countries. Intoxication was the most common cause in adult and pediatric care. The number of cases with indeterminate etiology is low. Diagnostic tools and specific treatment options are broadly available within this network. This is the first approach to report on etiology and outcome of ALF in the pediatric and adult population in Europe. High diagnostic yield and standard of care reflects the expert status of involved centers.

Identifiants

DOI: 10.1097/MPG.0000000000003777 PMID: 36930963
pubmed: 36930963
doi: 10.1097/MPG.0000000000003777
pii: 00005176-202307000-00018
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

115-120

Informations de copyright

Copyright © 2023 by European Society for European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition.

Déclaration de conflit d'intérêts

The authors report no conflicts of interest.

Références

Tandon BN, Bernauau J, O’Grady J, et al. Recommendations of the International Association for the Study of the Liver Subcommittee on nomenclature of acute and subacute liver failure. J Gastroenterol Hepatol. 1999;14:403–4.
Germani G, Theocharidou E, Adam R, et al. Liver transplantation for acute liver failure in Europe: outcomes over 20 years from the ELTR database. J Hepatol. 2012;57:288–96.
Ichai P, Legeai C, Francoz C, et al. Patients with acute liver failure listed for superurgent liver transplantation in France: reevaluation of the Clichy-Villejuif criteria. Liver Transpl. 2015;21:512–23.
Saliba F, Samuel D. Acute liver failure: current trends. J Hepatol. 2013;59:6–8.
Bernal W, Hyyrylainen A, Gera A, et al. Lessons from look-back in acute liver failure? A single centre experience of 3300 patients. J Hepatol. 2013;59:74–80.
Rabinowich L, Wendon J, Bernal W, Shibolet O. Clinical management of acute liver failure: results of an international multi-center survey. World J Gastroenterol. 2016;22:7595–603.
Larson-Nath C, Vitola B. Pediatric acute liver failure. Crit Care Clin. 2022;38:301–15.
Narkewicz MR, Horslen S, Hardison RM, et al. A learning collaborative approach increases specificity of diagnosis of acute liver failure in pediatric patients. Clin Gastroenterol Hepatol. 2018;16:1801–1810.e3.
Di Giorgio A, Sonzogni A, Piccichè A, et al. Successful management of acute liver failure in Italian children: a 16-year experience at a referral centre for paediatric liver transplantation. Dig Liver Dis. 2017;49:1139–45.
Kathemann S, Bechmann LP, Sowa JP, et al. Etiology, outcome and prognostic factors of childhood acute liver failure in a German Single Center. Ann Hepatol. 2015;14:722–8.
ERN-RARE-LIVER. What is ERN RARE-LIVER?. https://rare-liver.eu/about/what-is-ern-rare-liver . Accessed May 10, 2022.
Squires RH Jr, Shneider BL, Bucuvalas J, et al. Acute liver failure in children: the first 348 patients in the pediatric acute liver failure study group. J Pediatr. 2006;148:652–8.
Wendon J, Cordoba J, Dhawan A, et al. EASL Clinical Practical Guidelines on the management of acute (fulminant) liver failure. J Hepatol. 2017;66:1047–81.
Alexander EC, Deep A. Therapeutic plasma exchange in children with acute liver failure (ALF): is it time for incorporation into the ALF armamentarium? Pediatr Nephrol. 2022;37:1775–88.
Larsen FS, Schmidt LE, Bernsmeier C, et al. High-volume plasma exchange in patients with acute liver failure: an open randomised controlled trial. J Hepatol. 2016;64:69–78.
Jørgensen MH, Rasmussen A, Christensen VB, et al. Safety of high-volume plasmapheresis in children with acute liver failure. J Pediatr Gastroenterol Nutr. 2021;72:815–9.
Bernal W, Wendon J. Acute liver failure. N Engl J Med. 2013;369:2525–34.
Breil T, Wenning D, Teufel U, et al. An assessment of publication status of pediatric liver transplantation studies. PLoS One. 2016;11:e0168251.
Patry C, Fichtner A, Höcker B, Ries M, Schmitt CP, Tönshoff B. Missing trial results: analysis of the current publication rate of studies in pediatric dialysis from 2003 to 2020. Pediatr Nephrol. 2023;38:227–36.
Meyburg J, Ries M. Publication bias in pediatric emergence delirium: a cross-sectional analysis of ClinicalTrials.gov and ClinicalTrialsRegister.eu. BMJ Open. 2020;10:e037346.

Auteurs

Dominic Lenz (D)

From the Department of Pediatrics I, Center for Pediatric and Adolescent Medicine, University Hospital Heidelberg, Heidelberg, Germany.
European Reference Network on Hepatological Diseases (ERN RARE-LIVER), Hamburg, Germany.

Marianne Hørby Jørgensen (M)

European Reference Network on Hepatological Diseases (ERN RARE-LIVER), Hamburg, Germany.
the Department of Pediatrics and Adolescent Medicine, Rigshospitalet Copenhagen University Hospital, Copenhagen, Denmark.

Deirdre Kelly (D)

European Reference Network on Hepatological Diseases (ERN RARE-LIVER), Hamburg, Germany.
the Liver Unit, Birmingham Women's and Children's Hospital, University of Birmingham, Birmingham, United Kingdom.

Vincenzo Cardinale (V)

European Reference Network on Hepatological Diseases (ERN RARE-LIVER), Hamburg, Germany.
the Medical-Surgical and Biotechnologies Sciences, Polo Pontino, Sapienza University of Rome, Latina, Italy.

Anja Geerts (A)

European Reference Network on Hepatological Diseases (ERN RARE-LIVER), Hamburg, Germany.
the Hepatology Research Unit, Department of Internal Medicine and Paediatrics, Liver Research Center Ghent, Ghent University, Ghent, Belgium.

Isabel Gonçalves Costa (I)

European Reference Network on Hepatological Diseases (ERN RARE-LIVER), Hamburg, Germany.
the Unidade de Hepatologia e Transplantação Hepática Pediátrica, Hospital Pediátrico de Coimbra, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.

Alexander Fichtner (A)

From the Department of Pediatrics I, Center for Pediatric and Adolescent Medicine, University Hospital Heidelberg, Heidelberg, Germany.
European Reference Network on Hepatological Diseases (ERN RARE-LIVER), Hamburg, Germany.

Sven F Garbade (SF)

From the Department of Pediatrics I, Center for Pediatric and Adolescent Medicine, University Hospital Heidelberg, Heidelberg, Germany.
European Reference Network on Hepatological Diseases (ERN RARE-LIVER), Hamburg, Germany.

Bianca Hegen (B)

European Reference Network on Hepatological Diseases (ERN RARE-LIVER), Hamburg, Germany.
University Children's Hospital, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Johannes Hilberath (J)

European Reference Network on Hepatological Diseases (ERN RARE-LIVER), Hamburg, Germany.
Paediatric Gastroenterology/Hepatology, University Hospital Tuebingen, Tuebingen, Germany.

Ruben de Kleine (R)

European Reference Network on Hepatological Diseases (ERN RARE-LIVER), Hamburg, Germany.
the Department of Surgery, Division of Hepatobiliary Surgery and Liver Transplantation, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.

Limas Kupčinskas (L)

European Reference Network on Hepatological Diseases (ERN RARE-LIVER), Hamburg, Germany.
Institute for Digestive Research and Department of Gastroenterology, Lithuanian University of Health Sciences, Kaunas, Lithuania.

Valérie McLin (V)

European Reference Network on Hepatological Diseases (ERN RARE-LIVER), Hamburg, Germany.
the Swiss Pediatric Liver Center, Division of Pediatric Specialties, Department of Pediatrics, Gynecology and Obstetrics, University Hospitals Geneva and University of Geneva, Geneva, Switzerland.

Moritz Niesert (M)

From the Department of Pediatrics I, Center for Pediatric and Adolescent Medicine, University Hospital Heidelberg, Heidelberg, Germany.
European Reference Network on Hepatological Diseases (ERN RARE-LIVER), Hamburg, Germany.

Veronica Prado Gonzalez (V)

European Reference Network on Hepatological Diseases (ERN RARE-LIVER), Hamburg, Germany.
Centre Hospitalier de Luxembourg, Luxembourg, Luxembourg.

Ekkehard Sturm (E)

European Reference Network on Hepatological Diseases (ERN RARE-LIVER), Hamburg, Germany.
Paediatric Gastroenterology/Hepatology, University Hospital Tuebingen, Tuebingen, Germany.

Christian Staufner (C)

From the Department of Pediatrics I, Center for Pediatric and Adolescent Medicine, University Hospital Heidelberg, Heidelberg, Germany.
European Reference Network on Hepatological Diseases (ERN RARE-LIVER), Hamburg, Germany.

Eric Tjwa (E)

European Reference Network on Hepatological Diseases (ERN RARE-LIVER), Hamburg, Germany.
the Department of Gastroenterology and Hepatology, Radboud University Medical Center, Nijmegen, The Netherlands.

José Willemse (J)

European Reference Network on Hepatological Diseases (ERN RARE-LIVER), Hamburg, Germany.
Dutch Liver Patient Association (NLV), Hoogland, The Netherlands.

Britta F Zecher (BF)

European Reference Network on Hepatological Diseases (ERN RARE-LIVER), Hamburg, Germany.
the I. Department of Medicine, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.

Fin Stolze Larsen (FS)

European Reference Network on Hepatological Diseases (ERN RARE-LIVER), Hamburg, Germany.
the Department of Gastroenterology and Hepatology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

Marcial Sebode (M)

European Reference Network on Hepatological Diseases (ERN RARE-LIVER), Hamburg, Germany.
the I. Department of Medicine, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.

Henriette Ytting (H)

European Reference Network on Hepatological Diseases (ERN RARE-LIVER), Hamburg, Germany.
the Gastro Unit, Medical Division, Hvidovre University Hospital, Copenhagen, Denmark.
the Department of Clinical Medicine, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Etiology and Outcome of Adult and Pediatric...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Etiology and Outcome of Adult and Pediatric...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Etiology and Outcome of Adult and Pediatric...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies du foie › Insuffisance hépatique › Défaillance hépatique › Défaillance hépatique aigüe › Etiology and Outcome of Adult and Pediatric...
questionsmedicales.fr › Régions géographiques › Europe › Etiology and Outcome of Adult and Pediatric...
questionsmedicales.fr › Procédures de chirurgie opératoire › Transplantation › Transplantation de tissu › Transplantation hépatique › Etiology and Outcome of Adult and Pediatric...
questionsmedicales.fr › Troubles dus à des produits chimiques › Intoxication › Lésions hépatiques dues aux substances › Etiology and Outcome of Adult and Pediatric...