Skin-interfaced electronics: A promising and intelligent paradigm for personalized healthcare.
Biomaterials
Biosensors
Flexible bioelectronics
Machine learning
Personalized healthcare
Strain-insensitive
Journal
Biomaterials
ISSN: 1878-5905
Titre abrégé: Biomaterials
Pays: Netherlands
ID NLM: 8100316
Informations de publication
Date de publication:
05 2023
05 2023
Historique:
received:
26
10
2022
revised:
23
02
2023
accepted:
02
03
2023
pmc-release:
01
05
2024
medline:
11
4
2023
pubmed:
18
3
2023
entrez:
17
3
2023
Statut:
ppublish
Résumé
Skin-interfaced electronics (skintronics) have received considerable attention due to their thinness, skin-like mechanical softness, excellent conformability, and multifunctional integration. Current advancements in skintronics have enabled health monitoring and digital medicine. Particularly, skintronics offer a personalized platform for early-stage disease diagnosis and treatment. In this comprehensive review, we discuss (1) the state-of-the-art skintronic devices, (2) material selections and platform considerations of future skintronics toward intelligent healthcare, (3) device fabrication and system integrations of skintronics, (4) an overview of the skintronic platform for personalized healthcare applications, including biosensing as well as wound healing, sleep monitoring, the assessment of SARS-CoV-2, and the augmented reality-/virtual reality-enhanced human-machine interfaces, and (5) current challenges and future opportunities of skintronics and their potentials in clinical translation and commercialization. The field of skintronics will not only minimize physical and physiological mismatches with the skin but also shift the paradigm in intelligent and personalized healthcare and offer unprecedented promise to revolutionize conventional medical practices.
Identifiants
pubmed: 36931103
pii: S0142-9612(23)00083-2
doi: 10.1016/j.biomaterials.2023.122075
pmc: PMC10085866
mid: NIHMS1884008
pii:
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
122075Subventions
Organisme : NIDDK NIH HHS
ID : R21 DK128711
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM125055
Pays : United States
Informations de copyright
Copyright © 2023 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Références
Adv Mater. 2016 Dec;28(46):10257-10265
pubmed: 27714861
J Mater Chem B. 2014 Sep 21;2(35):5739-5745
pubmed: 32262017
Science. 2009 Jun 19;324(5934):1530-4
pubmed: 19541989
Nat Nanotechnol. 2012 Dec;7(12):803-9
pubmed: 23178335
Sci Adv. 2015 Oct 30;1(9):e1500701
pubmed: 26601309
ACS Appl Mater Interfaces. 2022 Jan 12;14(1):2401-2410
pubmed: 34968024
Epilepsia. 2021 Aug;62(8):1807-1819
pubmed: 34268728
Temperature (Austin). 2019 Jul 17;6(3):211-259
pubmed: 31608304
N Engl J Med. 2019 Apr 4;380(14):1347-1358
pubmed: 30943338
IEEE Electron Device Lett. 2021 Jan;42(1):46-49
pubmed: 33746352
Nat Genet. 2019 Jan;51(1):12-18
pubmed: 30478442
Mater Sci Eng C Mater Biol Appl. 2018 May 1;86:151-172
pubmed: 29525090
Nanoscale. 2017 Jul 13;9(27):9562-9571
pubmed: 28664948
Sci Transl Med. 2016 Nov 23;8(366):366ra162
pubmed: 27881823
ACS Biomater Sci Eng. 2020 Aug 10;6(8):4337-4355
pubmed: 33455178
Lancet Digit Health. 2021 Apr;3(4):e266-e273
pubmed: 33640306
ACS Nano. 2021 Jun 22;15(6):9955-9966
pubmed: 34110782
Adv Mater. 2013 May 28;25(20):2773-8
pubmed: 23440975
Adv Mater. 2020 Sep;32(37):e2001903
pubmed: 32743815
Biomaterials. 2022 Jun;285:121479
pubmed: 35487064
ACS Sens. 2020 Nov 25;5(11):3346-3364
pubmed: 33185417
Small. 2020 Apr;16(15):e1901124
pubmed: 31364311
Anal Chem. 2015 Jan 6;87(1):394-8
pubmed: 25496376
Analyst. 2021 May 21;146(10):3273-3279
pubmed: 33999074
Circ Heart Fail. 2020 Mar;13(3):e006513
pubmed: 32093506
Adv Mater. 2010 Feb 2;22(5):651-5
pubmed: 20217767
Adv Mater. 2014 Oct 22;26(39):6670-87
pubmed: 25252266
Biomaterials. 2017 Sep;139:229-243
pubmed: 28579065
Matter. 2021 Sep 1;4(9):2886-2901
pubmed: 34746749
ACS Nano. 2011 Aug 23;5(8):6564-70
pubmed: 21749099
Chem Soc Rev. 2014 Jan 21;43(2):588-610
pubmed: 24121237
Nano Lett. 2019 Sep 11;19(9):6592-6599
pubmed: 31434486
NPJ Digit Med. 2020 Nov 11;3(1):148
pubmed: 33299137
Brain Res Bull. 2010 Apr 29;82(1-2):104-8
pubmed: 20117179
Adv Mater. 2013 Mar 20;25(11):1589-92
pubmed: 23334983
Biosens Bioelectron. 2020 Nov 15;168:112450
pubmed: 32877780
Chem Soc Rev. 2020 Nov 21;49(22):7978-8035
pubmed: 32672777
Adv Mater. 2012 Jan 17;24(3):398-401
pubmed: 22183927
Analyst. 2013 Nov 21;138(22):7031-8
pubmed: 24098883
Inflamm Bowel Dis. 2020 Sep 18;26(10):1533-1542
pubmed: 32720974
ACS Nano. 2015 Jun 23;9(6):6626-33
pubmed: 26027637
Microsyst Nanoeng. 2021 Nov 26;7:96
pubmed: 34900330
ACS Nano. 2019 Mar 26;13(3):3023-3030
pubmed: 30768896
Biosens Bioelectron. 2021 Mar 1;175:112844
pubmed: 33248878
ACS Nano. 2010 Jan 26;4(1):30-4
pubmed: 20025290
Science. 2014 Apr 4;344(6179):70-4
pubmed: 24700852
J Invest Dermatol. 1991 Apr;96(4):495-9
pubmed: 2007788
Nature. 2015 May 28;521(7553):436-44
pubmed: 26017442
Int J Mol Sci. 2016 Mar 03;17(3):334
pubmed: 26950123
Biotechnol Adv. 2016 Jul-Aug;34(4):422-434
pubmed: 26724184
Sci Transl Med. 2018 Oct 31;10(465):
pubmed: 30381410
ACS Sens. 2020 Sep 25;5(9):2834-2842
pubmed: 32854495
Analyst. 2021 Jun 7;146(11):3482-3492
pubmed: 33955985
Nano Lett. 2019 Feb 13;19(2):1143-1150
pubmed: 30657695
Nat Commun. 2020 Nov 6;11(1):5629
pubmed: 33159080
Adv Mater. 2016 Jun;28(22):4184-202
pubmed: 26728114
Chem Commun (Camb). 2015 Feb 18;51(14):2991-4
pubmed: 25598312
Nature. 2016 Nov 16;539(7629):411-415
pubmed: 27853213
ACS Nano. 2022 Jan 25;16(1):473-484
pubmed: 34918906
Sci Adv. 2019 Jan 25;5(1):eaau6356
pubmed: 30746456
Nature. 2005 Oct 27;437(7063):1264-71
pubmed: 16251951
Nat Biomed Eng. 2018 Oct;2(10):719-731
pubmed: 31015651
ACS Nano. 2017 Aug 22;11(8):7634-7641
pubmed: 28719739
Small. 2018 Jan;14(3):
pubmed: 29205836
Nat Biotechnol. 2014 Jul;32(7):642-3
pubmed: 25004232
ACS Appl Mater Interfaces. 2018 Jan 31;10(4):3634-3643
pubmed: 29297670
Nat Biomed Eng. 2021 Jul;5(7):772-782
pubmed: 33941897
Sci Rep. 2016 May 17;6:26094
pubmed: 27185194
Am J Clin Dermatol. 2017 Feb;18(1):59-65
pubmed: 27722955
ACS Nano. 2019 Nov 26;13(11):12280-12286
pubmed: 31725255
Front Neurol. 2021 Jul 13;12:690404
pubmed: 34326807
Nature. 2019 Nov;575(7783):473-479
pubmed: 31748722
Adv Mater. 2014 Jun 11;26(22):3638-43
pubmed: 24554600
Nano Lett. 2017 Nov 8;17(11):6961-6967
pubmed: 29058919
Adv Mater. 2022 Dec;34(49):e2205498
pubmed: 36268986
Sleep Med Clin. 2017 Mar;12(1):1-22
pubmed: 28159089
Adv Mater. 2018 Jan;30(4):
pubmed: 29205532
Nat Rev Neurosci. 2001 Jan;2(1):51-61
pubmed: 11253359
Science. 2022 Dec 16;378(6625):1222-1227
pubmed: 36520906
Angew Chem Int Ed Engl. 2016 Mar 7;55(11):3566-79
pubmed: 26749063
Artif Cells Nanomed Biotechnol. 2018;46(sup1):906-911
pubmed: 29448839
Science. 2011 Aug 12;333(6044):838-43
pubmed: 21836009
Trends Biotechnol. 2013 May;31(5):295-304
pubmed: 23434154
Small. 2020 Jul;16(28):e2000450
pubmed: 32529803
Adv Sci (Weinh). 2019 May 21;6(14):1900290
pubmed: 31380208
Nat Nanotechnol. 2017 Sep;12(9):907-913
pubmed: 28737748
Sci Transl Med. 2018 Apr 4;10(435):
pubmed: 29618561
Adv Mater. 2010 Dec 14;22(47):5424-30
pubmed: 20839257
Sci Adv. 2020 Jun 26;6(26):eaba9624
pubmed: 32637619
Adv Mater. 2019 Oct;31(41):e1903789
pubmed: 31448484
J Invest Dermatol. 1967 Jan;48(1):79-88
pubmed: 6018244
Clin Chem. 1957 Feb;3(1):37-48
pubmed: 13404762
Adv Mater. 2015 Feb 18;27(7):1255-61
pubmed: 25581228
J Surg Res. 1991 Apr;50(4):308-13
pubmed: 2020184
Int J Pharm. 2016 Feb 29;499(1-2):376-394
pubmed: 26757150
NPJ Digit Med. 2021 Jan 8;4(1):5
pubmed: 33420381
Nature. 2008 Feb 21;451(7181):977-80
pubmed: 18288191
ACS Sens. 2022 Jul 22;7(7):2037-2048
pubmed: 35820167
Small. 2023 Mar;19(11):e2207017
pubmed: 36564357
ACS Sens. 2022 Feb 25;7(2):441-452
pubmed: 35175733
Adv Mater. 2017 Oct;29(39):
pubmed: 28833673
Adv Mater. 2014 Jun 18;26(23):3905-11
pubmed: 24692101
ACS Nano. 2021 Feb 23;15(2):2800-2811
pubmed: 33470791
Adv Mater. 2018 Dec;30(50):e1801368
pubmed: 30073715
Nano Lett. 2010 Apr 14;10(4):1276-9
pubmed: 20350007
IEEE J Biomed Health Inform. 2018 Sep;22(5):1589-1604
pubmed: 29989977
Adv Healthc Mater. 2015 Aug 26;4(12):1742-62
pubmed: 26097108
Nat Mater. 2010 Jun;9(6):511-7
pubmed: 20400953
Biomaterials. 2021 Sep;276:121026
pubmed: 34298443
Nat Commun. 2020 Jan 8;11(1):119
pubmed: 31913282
Anal Chem. 2021 Sep 21;93(37):12767-12775
pubmed: 34477377
Sensors (Basel). 2016 Feb 06;16(2):223
pubmed: 26861346
Nat Nanotechnol. 2019 May;14(5):447-455
pubmed: 30804482
Biomater Sci. 2020 Dec 15;8(24):6812-6813
pubmed: 33185214
Chem Soc Rev. 2019 Mar 18;48(6):1566-1595
pubmed: 30519703
J Physiol. 1956 Apr 27;132(1):225-31
pubmed: 13320386
Adv Funct Mater. 2022 Apr 25;32(17):
pubmed: 36186921
Nano Lett. 2018 Jun 13;18(6):3593-3599
pubmed: 29767529
Sci Adv. 2019 Sep 13;5(9):eaaw7846
pubmed: 31548984
J Electr Bioimpedance. 2022 May 20;13(1):21-24
pubmed: 35646198
Nat Nanotechnol. 2017 Sep;12(9):839-840
pubmed: 28737749
Adv Mater. 2022 Jun;34(24):e2108389
pubmed: 35130584
Nat Rev Genet. 2019 Jul;20(7):389-403
pubmed: 30971806
Anal Chem. 2020 Jul 21;92(14):10153-10161
pubmed: 32588617
Physiol Rev. 1954 Apr;34(2):202-20
pubmed: 13155186
Anal Chem. 2013 Jul 16;85(14):6553-60
pubmed: 23815621
Acta Biomater. 2017 Feb;49:66-77
pubmed: 27826004
Sci Adv. 2019 Nov 01;5(11):eaay0418
pubmed: 31701008
Nat Med. 2021 Jun;27(6):1105-1112
pubmed: 34031607
Sci Transl Med. 2020 Dec 16;12(574):
pubmed: 33328330
Nat Nanotechnol. 2019 Jul;14(7):719-727
pubmed: 31235893
Nano Today. 2014 Oct 1;9(5):574-589
pubmed: 25530795
Adv Mater. 2018 Jun;30(26):e1800109
pubmed: 29761554
Small. 2017 Mar;13(9):
pubmed: 28026109
Small. 2018 Nov;14(47):e1803192
pubmed: 30369049
Adv Mater. 2012 May 15;24(19):2578-81, 2509
pubmed: 22488916
Nat Mater. 2020 Jan;19(1):102-108
pubmed: 31844276
Annu Int Conf IEEE Eng Med Biol Soc. 2016 Aug;2016:4201-4203
pubmed: 28269209
Bioact Mater. 2021 Dec 30;15:214-249
pubmed: 35386359
Adv Mater. 2021 Jun;33(24):e2008308
pubmed: 33955069
Adv Sci (Weinh). 2019 Apr 01;6(11):1900186
pubmed: 31179225
Nat Mater. 2018 Jul;17(7):618-624
pubmed: 29784995
Adv Mater. 2023 Mar;35(10):e2209300
pubmed: 36576895
Adv Mater. 2020 Jun;32(22):e2000991
pubmed: 32323403
Chem Rev. 2016 Jan 13;116(1):215-57
pubmed: 26691648
Small. 2017 Jan;13(2):
pubmed: 27779812
ACS Appl Mater Interfaces. 2018 Jan 31;10(4):3921-3928
pubmed: 29309113
Sci Rep. 2021 Apr 7;11(1):7567
pubmed: 33828178
ACS Nano. 2018 Oct 23;12(10):9742-9749
pubmed: 30226045
Science. 2022 Mar 25;375(6587):1411-1417
pubmed: 35324282
EBioMedicine. 2018 Jan;27:103-111
pubmed: 29262989
Nat Commun. 2020 Jul 30;11(1):3823
pubmed: 32732934
J Dent Res. 2010 Mar;89(3):219-29
pubmed: 20139336
Proc Natl Acad Sci U S A. 2020 Aug 4;117(31):18292-18301
pubmed: 32661158
Biomater Sci. 2017 Jul 25;5(8):1421-1434
pubmed: 28692083
Nat Nanotechnol. 2012 Dec;7(12):825-32
pubmed: 23142944
Int J Biol Macromol. 2019 Oct 15;139:975-993
pubmed: 31386871
Temperature (Austin). 2017 Nov 10;5(1):36-55
pubmed: 29687043
Nat Rev Cardiol. 2020 Jan;17(1):1-3
pubmed: 31605093
ACS Appl Mater Interfaces. 2018 Nov 7;10(44):38493-38505
pubmed: 30351905
Nature. 2005 Oct 27;437(7063):1272-8
pubmed: 16251952
Sensors (Basel). 2020 Mar 30;20(7):
pubmed: 32235461
Microsyst Nanoeng. 2020 May 18;6:46
pubmed: 34567658
Science. 2017 Oct 20;358(6361):332-335
pubmed: 29051372
Nat Commun. 2019 Apr 17;10(1):1795
pubmed: 30996224
Adv Mater. 2010 Jun 11;22(22):2392-415
pubmed: 20432408
Bioact Mater. 2017 Dec 28;3(3):322-333
pubmed: 29744469
J Physiol Sci. 2012 Nov;62(6):429-40
pubmed: 22678934
Nat Med. 2021 Sep;27(9):1514-1515
pubmed: 34518677
Nat Rev Mater. 2021;6(4):286-288
pubmed: 33680503
Small Methods. 2022 Jan;6(1):e2100900
pubmed: 35041280
Small. 2021 Nov;17(45):e2100692
pubmed: 34310048
Biomater Sci. 2021 Oct 12;9(20):6653-6672
pubmed: 34550125
Bioact Mater. 2022 Nov 24;23:314-327
pubmed: 36439081
Proc Natl Acad Sci U S A. 2017 May 16;114(20):5107-5112
pubmed: 28461459
ACS Biomater Sci Eng. 2021 Nov 16;:
pubmed: 34784170
Commun Med (Lond). 2021 Aug 23;1:25
pubmed: 34522916
J Clin Med. 2020 Nov 25;9(12):
pubmed: 33255705
Adv Mater. 2020 Apr;32(15):e1902278
pubmed: 31468635
Epilepsia. 2021 Mar;62 Suppl 2:S116-S124
pubmed: 32712958
ACS Appl Mater Interfaces. 2021 Jul 21;13(28):33557-33565
pubmed: 34250798
Sensors (Basel). 2020 Apr 29;20(9):
pubmed: 32365645
Nat Commun. 2020 Mar 25;11(1):1551
pubmed: 32214095
Nat Nanotechnol. 2018 Nov;13(11):1048-1056
pubmed: 30104619
Adv Mater. 2018 Oct;30(43):e1803388
pubmed: 30216564
Biosens Bioelectron. 2014 Apr 15;54:603-9
pubmed: 24333582
J Invest Dermatol. 1984 Feb;82(2):188-94
pubmed: 6693781
Biosens Bioelectron. 2020 Dec 15;170:112675
pubmed: 33038583
ACS Appl Mater Interfaces. 2019 Mar 27;11(12):11194-11201
pubmed: 30830737
Nature. 2016 Jan 28;529(7587):509-514
pubmed: 26819044
Nanoscale. 2020 Aug 6;12(30):15993-16007
pubmed: 32700717
Maturitas. 2018 Jul;113:40-47
pubmed: 29903647
ACS Appl Mater Interfaces. 2021 Nov 17;13(45):54456-54465
pubmed: 34726900
Nat Commun. 2017 Oct 31;8(1):1207
pubmed: 29089488
Nanoscale. 2019 Nov 7;11(41):18923-18945
pubmed: 31532436
Sci Adv. 2018 Sep 21;4(9):eaau0920
pubmed: 30255151
Nat Commun. 2021 May 11;12(1):2725
pubmed: 33976166
NPJ Digit Med. 2018 May 8;1:18
pubmed: 31304302
J Biomater Sci Polym Ed. 2020 Mar;31(4):549-560
pubmed: 31902299
ACS Sens. 2021 Jun 25;6(6):2181-2190
pubmed: 34038108
Nat Commun. 2022 Dec 15;13(1):7757
pubmed: 36522334
Biosens Bioelectron. 2009 Dec 15;25(4):708-14
pubmed: 19733046
Sensors (Basel). 2021 Jan 07;21(2):
pubmed: 33430220
Nat Mater. 2013 Oct;12(10):938-44
pubmed: 24037122
Nature. 2013 Aug 1;500(7460):59-63
pubmed: 23863931
ACS Sens. 2020 Jul 24;5(7):2086-2095
pubmed: 32551595
Science. 2010 Jun 11;328(5984):1373-6
pubmed: 20538944
Chem Rev. 2021 Feb 24;121(4):2109-2146
pubmed: 33460327
Microsyst Nanoeng. 2021 Mar 17;7:25
pubmed: 34567739
Angew Chem Int Ed Engl. 2014 Sep 1;53(36):9526-31
pubmed: 25044134
Nat Chem. 2012 Apr 01;4(6):467-72
pubmed: 22614381
Angew Chem Int Ed Engl. 2012 Oct 15;51(42):10561-5
pubmed: 22987779
Adv Sci (Weinh). 2020 Sep 24;7(21):1902740
pubmed: 33173720
Nat Rev Cardiol. 2021 Feb;18(2):75-91
pubmed: 33037325
Sci Adv. 2018 Jun 15;4(6):eaat0098
pubmed: 29922718
Biotechnology (N Y). 1994 Jul;12(7):689-93
pubmed: 7764913
Proc Natl Acad Sci U S A. 2021 May 11;118(19):
pubmed: 33893178
Small. 2015 Feb 25;11(8):906-12
pubmed: 25367846
Adv Healthc Mater. 2020 Jul;9(13):e2000310
pubmed: 32449317
Nat Chem. 2013 Dec;5(12):1042-8
pubmed: 24256869
Nat Mater. 2017 Aug;16(8):834-840
pubmed: 28504674
Adv Healthc Mater. 2021 Jan;10(1):e2001125
pubmed: 32996270
Anal Chem. 2020 Mar 17;92(6):4647-4655
pubmed: 32069026
Int Wound J. 2016 Jul;13 Suppl 2:5-15
pubmed: 27460943
Nat Mater. 2020 Nov;19(11):1230-1235
pubmed: 32719508
Nat Commun. 2017 Jun 21;8:15894
pubmed: 28635956
Adv Mater. 2013 Feb 25;25(8):1173-9
pubmed: 23184492
Adv Mater. 2016 Apr 6;28(13):2556-62
pubmed: 26833813
Adv Healthc Mater. 2021 Sep;10(18):e2100046
pubmed: 34263551
J Am Coll Health. 2017 Apr;65(3):187-196
pubmed: 27937737
Proc Natl Acad Sci U S A. 2014 Dec 9;111(49):17385-9
pubmed: 25422476
Chem Soc Rev. 2022 May 10;51(9):3759-3793
pubmed: 35420617
Adv Mater. 2017 Jul;29(27):
pubmed: 28417536