Internal capsule microstructure mediates the relationship between childhood maltreatment and PTSD following adulthood trauma exposure.
Journal
Molecular psychiatry
ISSN: 1476-5578
Titre abrégé: Mol Psychiatry
Pays: England
ID NLM: 9607835
Informations de publication
Date de publication:
17 Mar 2023
17 Mar 2023
Historique:
received:
14
10
2022
accepted:
22
02
2023
revised:
17
02
2023
pmc-release:
17
09
2024
entrez:
18
3
2023
pubmed:
19
3
2023
medline:
19
3
2023
Statut:
aheadofprint
Résumé
Childhood trauma is a known risk factor for trauma and stress-related disorders in adulthood. However, limited research has investigated the impact of childhood trauma on brain structure linked to later posttraumatic dysfunction. We investigated the effect of childhood trauma on white matter microstructure after recent trauma and its relationship with future posttraumatic dysfunction among trauma-exposed adult participants (n = 202) recruited from emergency departments as part of the AURORA Study. Participants completed self-report scales assessing prior childhood maltreatment within 2-weeks in addition to assessments of PTSD, depression, anxiety, and dissociation symptoms within 6-months of their traumatic event. Fractional anisotropy (FA) obtained from diffusion tensor imaging (DTI) collected at 2-weeks and 6-months was used to index white matter microstructure. Childhood maltreatment load predicted 6-month PTSD symptoms (b = 1.75, SE = 0.78, 95% CI = [0.20, 3.29]) and inversely varied with FA in the bilateral internal capsule (IC) at 2-weeks (p = 0.0294, FDR corrected) and 6-months (p = 0.0238, FDR corrected). We observed a significant indirect effect of childhood maltreatment load on 6-month PTSD symptoms through 2-week IC microstructure (b = 0.37, Boot SE = 0.18, 95% CI = [0.05, 0.76]) that fully mediated the effect of childhood maltreatment load on PCL-5 scores (b = 1.37, SE = 0.79, 95% CI = [-0.18, 2.93]). IC microstructure did not mediate relationships between childhood maltreatment and depressive, anxiety, or dissociative symptomatology. Our findings suggest a unique role for IC microstructure as a stable neural pathway between childhood trauma and future PTSD symptoms following recent trauma. Notably, our work did not support roles of white matter tracts previously found to vary with PTSD symptoms and childhood trauma exposure, including the cingulum bundle, uncinate fasciculus, and corpus callosum. Given the IC contains sensory fibers linked to perception and motor control, childhood maltreatment might impact the neural circuits that relay and process threat-related inputs and responses to trauma.
Identifiants
pubmed: 36932158
doi: 10.1038/s41380-023-02012-3
pii: 10.1038/s41380-023-02012-3
pmc: PMC10505244
mid: NIHMS1901462
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIMH NIH HHS
ID : K01 MH121653
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD079076
Pays : United States
Organisme : NIMH NIH HHS
ID : K00 MH119603
Pays : United States
Organisme : NICHD NIH HHS
ID : R03 HD094577
Pays : United States
Organisme : NIA NIH HHS
ID : F33 AG005654
Pays : United States
Organisme : NIMH NIH HHS
ID : U01 MH110925
Pays : United States
Organisme : NIMH NIH HHS
ID : K01 MH118467
Pays : United States
Informations de copyright
© 2023. The Author(s).
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