Maternal genetic history of ancient Tibetans over the past 4,000 years.

Ancient DNA Mitochondrial genome Population history Tibetans

Journal

Journal of genetics and genomics = Yi chuan xue bao
ISSN: 1673-8527
Titre abrégé: J Genet Genomics
Pays: China
ID NLM: 101304616

Informations de publication

Date de publication:
16 Mar 2023
Historique:
received: 17 01 2023
revised: 14 03 2023
accepted: 14 03 2023
pubmed: 19 3 2023
medline: 19 3 2023
entrez: 18 3 2023
Statut: aheadofprint

Résumé

The settlement of the Tibetan Plateau epitomizes human adaptation to a high-altitude environment that poses great challenges to human activity. Here, we reconstruct a 4,000-year maternal genetic history of Tibetans using 128 ancient mitochondrial genome data from 37 sites in Tibet. The phylogeny of haplotypes M9a1a, M9a1b, D4g2, G2a'c, and D4i show that ancient Tibetans shared the most recent common ancestor (TMRCA) with ancient Middle and Upper Yellow River populations around the Early and Middle Holocene. In addition, the connections between Tibetans and Northeastern Asians varied over the past 4,000 years, with a stronger matrilineal connection between the two during 4,000-3,000 BP, and a weakened connection after 3,000 BP, that were coincident with climate change, followed by a reinforced connection after the Tubo period (1,400-1,100 BP). Besides, an over 4,000-year matrilineal continuity was observed in some of the maternal lineages. We also found the maternal genetic structure of ancient Tibetans was correlated to the geography and interactions between ancient Tibetans and ancient Nepal and Pakistan populations. Overall, the maternal genetic history of Tibetans can be characterized as a long-term matrilineal continuity with frequent internal and external population interactions that were dynamically shaped by geography, climate changes, as well as historical events.

Identifiants

DOI: 10.1016/j.jgg.2023.03.007 PMID: 36933795
pubmed: 36933795
pii: S1673-8527(23)00071-1
doi: 10.1016/j.jgg.2023.03.007
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.

Déclaration de conflit d'intérêts

Conflicts of interest The authors declare that they have no conflict of interest.

Auteurs

Ganyu Zhang (G)

Key Laboratory of Vertebrate Evolution and Human Origins, Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences, Beijing 100044, China; University of Chinese Academy of Sciences, Beijing 100049, China.

Can Cui (C)

Key Laboratory of Vertebrate Evolution and Human Origins, Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences, Beijing 100044, China; University of Chinese Academy of Sciences, Beijing 100049, China.

Shargan Wangdue (S)

Tibet Institute for Conservation and Research of Cultural Relics, Lhasa 850000, China.

Hongliang Lu (H)

Center for Archaeological Science, School of Archaeology and Museology, Sichuan University, Chengdu, Sichuan 610064, China.

Honghai Chen (H)

School of Cultural Heritage, Northwest University, Xi'an, Shaanxi 710069, China.

Lin Xi (L)

Tibet Institute for Conservation and Research of Cultural Relics, Lhasa 850000, China.

Wei He (W)

Tibet Institute for Conservation and Research of Cultural Relics, Lhasa 850000, China.

Haibing Yuan (H)

Center for Archaeological Science, School of Archaeology and Museology, Sichuan University, Chengdu, Sichuan 610064, China.

Tinley Tsring (T)

Tibet Institute for Conservation and Research of Cultural Relics, Lhasa 850000, China.

Zujun Chen (Z)

Tibet Institute for Conservation and Research of Cultural Relics, Lhasa 850000, China.

Feng Yang (F)

Center for Archaeological Science, School of Archaeology and Museology, Sichuan University, Chengdu, Sichuan 610064, China.

Tashi Tsering (T)

Tibet Institute for Conservation and Research of Cultural Relics, Lhasa 850000, China.

Shuai Li (S)

Center for Archaeological Science, School of Archaeology and Museology, Sichuan University, Chengdu, Sichuan 610064, China.

Norbu Tashi (N)

Tibet Institute for Conservation and Research of Cultural Relics, Lhasa 850000, China.

Tsho Yang (T)

Tibet Institute for Conservation and Research of Cultural Relics, Lhasa 850000, China.

Yan Tong (Y)

Tibet Institute for Conservation and Research of Cultural Relics, Lhasa 850000, China.

Xiaohong Wu (X)

School of Archaeology and Museology, Peking University, Beijing 100871, China.

Linhui Li (L)

Tibet Institute for Conservation and Research of Cultural Relics, Lhasa 850000, China.

Yuanhong He (Y)

Center for Archaeological Science, School of Archaeology and Museology, Sichuan University, Chengdu, Sichuan 610064, China.

Peng Cao (P)

Key Laboratory of Vertebrate Evolution and Human Origins, Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences, Beijing 100044, China.

Qingyan Dai (Q)

Key Laboratory of Vertebrate Evolution and Human Origins, Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences, Beijing 100044, China.

Feng Liu (F)

Key Laboratory of Vertebrate Evolution and Human Origins, Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences, Beijing 100044, China.

Xiaotian Feng (X)

Key Laboratory of Vertebrate Evolution and Human Origins, Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences, Beijing 100044, China.

Tianyi Wang (T)

Key Laboratory of Vertebrate Evolution and Human Origins, Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences, Beijing 100044, China; University of Chinese Academy of Sciences, Beijing 100049, China.

Ruowei Yang (R)

Key Laboratory of Vertebrate Evolution and Human Origins, Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences, Beijing 100044, China.

Wanjing Ping (W)

Key Laboratory of Vertebrate Evolution and Human Origins, Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences, Beijing 100044, China.

Ming Zhang (M)

School of Cultural Heritage, Northwest University, Xi'an, Shaanxi 710069, China.

Xing Gao (X)

Key Laboratory of Vertebrate Evolution and Human Origins, Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences, Beijing 100044, China.

Yichen Liu (Y)

Key Laboratory of Vertebrate Evolution and Human Origins, Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences, Beijing 100044, China. Electronic address: yichen.liu@ivpp.ac.cn.

Wenjun Wang (W)

Key Laboratory of Vertebrate Evolution and Human Origins, Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences, Beijing 100044, China; Science and Technology Archaeology, National Centre for Archaeology, Beijing 100013, China. Electronic address: wangwenjun@ivpp.ac.cn.

Qiaomei Fu (Q)

Key Laboratory of Vertebrate Evolution and Human Origins, Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences, Beijing 100044, China; University of Chinese Academy of Sciences, Beijing 100049, China; Shanghai Qi Zhi Institute, Shanghai 200232, China. Electronic address: fuqiaomei@ivpp.ac.cn.

Classifications MeSH