Oncohistones in brain tumors: the soil and seed.

Child Young Adult Humans Histones / genetics Brain Neoplasms / genetics Chromatin Glioma / genetics Carcinogenesis / genetics Tumor Microenvironment / genetics
EZHIP G34R/V K27M PRC2 development epigenome gliomas oncohistones

Journal

Trends in cancer
ISSN: 2405-8025
Titre abrégé: Trends Cancer
Pays: United States
ID NLM: 101665956

Informations de publication

Date de publication:
05 2023
Historique:
received: 11 01 2023
revised: 11 02 2023
accepted: 21 02 2023
medline: 21 4 2023
pubmed: 19 3 2023
entrez: 18 3 2023
Statut: ppublish

Résumé

Recurrent somatic mutations in histone 3 (H3) variants (termed 'oncohistones') have been identified in high-grade gliomas (HGGs) in children and young adults and induce tumorigenesis through disruption of chromatin states. Oncohistones occur with exquisite neuroanatomical specificity and are associated with specific age distribution and epigenome landscapes. Here, we review the known intrinsic ('seed') and the extrinsic ('soil') factors needed for their optimal oncogenic effect and highlight the many unresolved questions regarding their effects on development and crosstalk with the tumor microenvironment. The 'seed and soil' analogy, used to explain tumor metastatic niches, also applies to oncohistones, which mainly thrive and flourish in specific chromatin states during very narrow windows of development, creating exquisite vulnerabilities, which could provide effective therapies for these deadly cancers.

Identifiants

DOI: 10.1016/j.trecan.2023.02.003 PMID: 36933956
pubmed: 36933956
pii: S2405-8033(23)00026-2
doi: 10.1016/j.trecan.2023.02.003
pii:
doi:

Substances chimiques

Histones 0
Chromatin 0

Types de publication

Journal Article Review Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

444-455

Subventions

Organisme : NCI NIH HHS
ID : P01 CA196539
Pays : United States

Informations de copyright

Copyright © 2023. Published by Elsevier Inc.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

Auteurs

Augusto Faria Andrade (AF)

Department of Human Genetics, McGill University, Montreal, QC, H3A 0C7, Canada.

Carol C L Chen (CCL)

Department of Human Genetics, McGill University, Montreal, QC, H3A 0C7, Canada.

Nada Jabado (N)

Department of Human Genetics, McGill University, Montreal, QC, H3A 0C7, Canada; Department of Pediatrics, McGill University, Montreal, QC, H3A 0C7, Canada; The Research Institute of the McGill University Health Centre, Montreal, QC, H4A 3J1, Canada. Electronic address: nada.jabado@mcgill.ca.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Oncohistones in brain tumors: the soil and seed.
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Jeune adulte › Oncohistones in brain tumors: the soil and seed.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Oncohistones in brain tumors: the soil and seed.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Histone › Oncohistones in brain tumors: the soil and seed.
questionsmedicales.fr › Maladies du système nerveux › Tumeurs du système nerveux › Tumeurs du système nerveux central › Tumeurs du cerveau › Oncohistones in brain tumors: the soil and seed.
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Structures de chromosome › Chromatine › Oncohistones in brain tumors: the soil and seed.
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu nerveux › Tumeurs neuroectodermiques › Tumeurs neuroépitheliales › Gliome › Oncohistones in brain tumors: the soil and seed.
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Processus néoplasiques › Carcinogenèse › Oncohistones in brain tumors: the soil and seed.
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Microenvironnement cellulaire › Microenvironnement tumoral › Oncohistones in brain tumors: the soil and seed.