Complex Structures Made Simple - Continuous Flow Production of Core Cross-Linked Polymeric Micelles for Paclitaxel Pro-Drug-Delivery.


Journal

Advanced materials (Deerfield Beach, Fla.)
ISSN: 1521-4095
Titre abrégé: Adv Mater
Pays: Germany
ID NLM: 9885358

Informations de publication

Date de publication:
May 2023
Historique:
revised: 10 02 2023
received: 17 11 2022
medline: 26 5 2023
pubmed: 20 3 2023
entrez: 19 3 2023
Statut: ppublish

Résumé

Translating innovative nanomaterials to medical products requires efficient manufacturing techniques that enable large-scale high-throughput synthesis with high reproducibility. Drug carriers in medicine embrace a complex subset of tasks calling for multifunctionality. Here, the synthesisof pro-drug-loaded core cross-linked polymeric micelles (CCPMs) in a continuous flow processis reported, which combines the commonly separated steps of micelle formation, core cross-linking, functionalization, and purification into a single process. Redox-responsive CCPMs are formed from thiol-reactive polypept(o)ides of polysarcosine-block-poly(S-ethylsulfonyl-l-cysteine) and functional cross-linkers based on dihydrolipoic acid hydrazide for pH-dependent release of paclitaxel. The precisely controlled microfluidic process allows the production of spherical micelles (D

Identifiants

pubmed: 36934295
doi: 10.1002/adma.202210704
doi:

Substances chimiques

Micelles 0
Paclitaxel P88XT4IS4D
Prodrugs 0
Polymers 0
Drug Carriers 0
Polyethylene Glycols 3WJQ0SDW1A

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2210704

Subventions

Organisme : Deutsche Forschungsgemeinschaft
ID : SFB1066

Informations de copyright

© 2023 The Authors. Advanced Materials published by Wiley-VCH GmbH.

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Auteurs

Tobias A Bauer (TA)

Leiden Academic Centre for Drug Research (LACDR), Leiden University, Einsteinweg 55, Leiden, 2333CC, The Netherlands.

Jonas Schramm (J)

Fraunhofer Institute for Microengineering and Microsystems, Carl-Zeiss-Str. 18-20, 55129, Mainz, Germany.

Federico Fenaroli (F)

Department for Biosciences, University of Oslo, Blindernveien 31, 0371, Oslo, Norway.

Svenja Siemer (S)

Molecular and Cellular Oncology/Nanobiomedicine, ENT Department, University Medical Center Mainz, Langenbeckstraße 1, 55131, Mainz, Germany.

Christine I Seidl (CI)

Leiden Academic Centre for Drug Research (LACDR), Leiden University, Einsteinweg 55, Leiden, 2333CC, The Netherlands.

Christine Rosenauer (C)

Max Planck Institute for Polymer Research, Ackermannweg 10, 55128, Mainz, Germany.

Regina Bleul (R)

Fraunhofer Institute for Microengineering and Microsystems, Carl-Zeiss-Str. 18-20, 55129, Mainz, Germany.

Roland H Stauber (RH)

Molecular and Cellular Oncology/Nanobiomedicine, ENT Department, University Medical Center Mainz, Langenbeckstraße 1, 55131, Mainz, Germany.

Kaloian Koynov (K)

Max Planck Institute for Polymer Research, Ackermannweg 10, 55128, Mainz, Germany.

Michael Maskos (M)

Fraunhofer Institute for Microengineering and Microsystems, Carl-Zeiss-Str. 18-20, 55129, Mainz, Germany.

Matthias Barz (M)

Leiden Academic Centre for Drug Research (LACDR), Leiden University, Einsteinweg 55, Leiden, 2333CC, The Netherlands.
Department of Dermatology, University Medical Center of the Johannes Gutenberg University Mainz, Langenbeckstraße 1, 55131, Mainz, Germany.

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