Dietary omega-3 fatty acids and endometrial cancer risk in the Epidemiology of Endometrial Cancer Consortium: An individual-participant meta-analysis.

Humans Female Prospective Studies Overweight Fatty Acids, Omega-3 Diet Obesity / epidemiology Endometrial Neoplasms / epidemiology Logistic Models Risk Factors
Endometrial cancer Fatty acid Omega-3 Polyunsaturated Uterine cancer

Journal

Gynecologic oncology
ISSN: 1095-6859
Titre abrégé: Gynecol Oncol
Pays: United States
ID NLM: 0365304

Informations de publication

Date de publication:
02 2023
Historique:
received: 08 06 2022
revised: 10 10 2022
accepted: 18 10 2022
entrez: 19 3 2023
pubmed: 20 3 2023
medline: 22 3 2023
Statut: ppublish

Résumé

Limited data from prospective studies suggest that higher dietary intake of long-chain omega-3 polyunsaturated fatty acids (LCn3PUFA), which hold anti-inflammatory properties, may reduce endometrial cancer risk; particularly among certain subgroups characterized by body mass and tumor pathology. Data from 12 prospective cohort studies participating in the Epidemiology of Endometrial Cancer Consortium were harmonized as nested case-control studies, including 7268 endometrial cancer cases and 26,133 controls. Habitual diet was assessed by food frequency questionnaire, from which fatty acid intakes were estimated. Two-stage individual-participant data mixed effects meta-analysis estimated adjusted odds ratios (OR) and 95% confidence intervals (CI) through logistic regression for associations between study-specific energy-adjusted quartiles of LCn3PUFA and endometrial cancer risk. Women with the highest versus lowest estimated dietary intakes of docosahexaenoic acid, the most abundant LCn3PUFA in diet, had a 9% increased endometrial cancer risk (Quartile 4 vs. Quartile 1: OR 1.09, 95% CI: 1.01-1.19; P trend = 0.04). Similar elevated risks were observed for the summary measure of total LCn3PUFA (OR 1.07, 95% CI: 0.99-1.16; P trend = 0.06). Stratified by body mass index, higher intakes of LCn3PUFA were associated with 12-19% increased endometrial cancer risk among overweight/obese women and no increased risk among normal-weight women. Higher associations appeared restricted to White women. The results did not differ by cancer grade. Higher dietary intakes of LCn3PUFA are unlikely to reduce endometrial cancer incidence; rather, they may be associated with small to moderate increases in risk in some subgroups of women, particularly overweight/obese women.

Sections du résumé

BACKGROUND
Limited data from prospective studies suggest that higher dietary intake of long-chain omega-3 polyunsaturated fatty acids (LCn3PUFA), which hold anti-inflammatory properties, may reduce endometrial cancer risk; particularly among certain subgroups characterized by body mass and tumor pathology.
MATERIALS AND METHODS
Data from 12 prospective cohort studies participating in the Epidemiology of Endometrial Cancer Consortium were harmonized as nested case-control studies, including 7268 endometrial cancer cases and 26,133 controls. Habitual diet was assessed by food frequency questionnaire, from which fatty acid intakes were estimated. Two-stage individual-participant data mixed effects meta-analysis estimated adjusted odds ratios (OR) and 95% confidence intervals (CI) through logistic regression for associations between study-specific energy-adjusted quartiles of LCn3PUFA and endometrial cancer risk.
RESULTS
Women with the highest versus lowest estimated dietary intakes of docosahexaenoic acid, the most abundant LCn3PUFA in diet, had a 9% increased endometrial cancer risk (Quartile 4 vs. Quartile 1: OR 1.09, 95% CI: 1.01-1.19; P trend = 0.04). Similar elevated risks were observed for the summary measure of total LCn3PUFA (OR 1.07, 95% CI: 0.99-1.16; P trend = 0.06). Stratified by body mass index, higher intakes of LCn3PUFA were associated with 12-19% increased endometrial cancer risk among overweight/obese women and no increased risk among normal-weight women. Higher associations appeared restricted to White women. The results did not differ by cancer grade.
CONCLUSION
Higher dietary intakes of LCn3PUFA are unlikely to reduce endometrial cancer incidence; rather, they may be associated with small to moderate increases in risk in some subgroups of women, particularly overweight/obese women.

Identifiants

DOI: 10.1016/j.ygyno.2022.10.015 PMID: 36934308 PMC: PMC10025515
pubmed: 36934308
pii: S0090-8258(22)01892-3
doi: 10.1016/j.ygyno.2022.10.015
pmc: PMC10025515
mid: NIHMS1848176
pii:
doi:

Substances chimiques

Fatty Acids, Omega-3 0

Types de publication

Meta-Analysis Journal Article Research Support, N.I.H., Intramural Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

137-146

Subventions

Organisme : NCI NIH HHS
ID : P30 CA016056
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA087969
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA250476
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA058598
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201100046C
Pays : United States
Organisme : WHI NIH HHS
ID : HHSN268201100003C
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201000046C
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA033619
Pays : United States
Organisme : WHI NIH HHS
ID : HHSN268201100002C
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA098346
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201100003I
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201100002I
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA202979
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA CP010196
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA118100
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA164974
Pays : United States
Organisme : NCI NIH HHS
ID : R03 CA212808
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201100004I
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA082838
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NCI NIH HHS
ID : R03 CA135632
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA058420
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201100006C
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA039742
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA083918
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA071789
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA164973
Pays : United States
Organisme : WHI NIH HHS
ID : HHSN268201100004C
Pays : United States
Organisme : NCI NIH HHS
ID : R03 CA169888
Pays : United States

Informations de copyright

Copyright © 2022 Elsevier Inc. All rights reserved.

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Auteurs

Theodore M Brasky (TM)

Department of Internal Medicine, Division of Medical Oncology, The Ohio State University College of Medicine, Columbus, OH, USA. Electronic address: Theodore.Brasky@osumc.edu.

Erinn M Hade (EM)

Department of Internal Medicine, Division of Medical Oncology, The Ohio State University College of Medicine, Columbus, OH, USA; Department of Population Health, Division of Biostatistics, New York University Grossman School of Medicine, New York, NY, USA.

David E Cohn (DE)

Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Columbus, OH, USA.

Alison M Newton (AM)

Department of Internal Medicine, Division of Medical Oncology, The Ohio State University College of Medicine, Columbus, OH, USA.

Stacey Petruzella (S)

Department of Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Kelli O'Connell (K)

Department of Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Kimberly A Bertrand (KA)

Slone Epidemiology Center at Boston University, Boston University School of Medicine, Boston, MA, USA.

Linda S Cook (LS)

Department of Epidemiology, Colorado School of Public Health, Aurora, CO, USA.

Immaculata De Vivo (I)

Department of Epidemiology, Harvard University, Boston, MA, USA.

Mengmeng Du (M)

Department of Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Jo L Freudenheim (JL)

Department of Epidemiology and Environmental Health, University at Buffalo, Buffalo, NY, USA.

Christine M Friedenreich (CM)

Cancer Epidemiology and Prevention Research, Cancer Care Alberta, Alberta Health Services, Calgary, AB, Canada; Departments of Oncology and Community Health Sciences, University of Calgary Cumming School of Medicine, Calgary, AB, Canada.

Marc T Goodman (MT)

Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars Sinai Medical Center, Los Angeles, CA, USA.

Jessica Gorzelitz (J)

Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.

Torukiri I Ibiebele (TI)

Population Health Department, QIMR Berghofer Medical Research Institute, Herston, Qld, Australia.

Vittorio Krogh (V)

Fondazione IRCCS - Istituto Nazionale dei Tumori di Milan, Milan, Italy.

Linda M Liao (LM)

Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute USA, Bethesda, MD, USA.

Loren Lipworth (L)

Department of Medicine, Division of Epidemiology, Vanderbilt University Medical Center, Nashville, TN, USA.

Lingeng Lu (L)

Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, USA.

Susan McCann (S)

Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY, USA.

Tracy A O'Mara (TA)

Computational Biology and Genetics Department, QIMR Berghofer Medical Research Institute, Herston, Qld, Australia.

Julie R Palmer (JR)

Slone Epidemiology Center at Boston University, Boston University School of Medicine, Boston, MA, USA.

Jeanette Ponte (J)

Department of Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Anna Prizment (A)

Department of Medicine, Division of Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, MN, USA.

Harvey Risch (H)

Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, USA.

Sven Sandin (S)

Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Seaver Autism Center for Research and Treatment at Mount Sinai, New York, NY, USA.

Leo J Schouten (LJ)

Department of Epidemiology, GROW-School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands.

Veronica Wendy Setiawan (VW)

Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA.

Xiao-Ou Shu (XO)

Department of Medicine, Division of Epidemiology, Vanderbilt University Medical Center, Nashville, TN, USA.

Britton Trabert (B)

Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA; Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of Utah School of Medicine and Huntsman Cancer Institute, Salt Lake City, UT, USA.

Piet A van den Brandt (PA)

Department of Epidemiology, GROW-School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands.

Penelope M Webb (PM)

Population Health Department, QIMR Berghofer Medical Research Institute, Herston, Qld, Australia.

Nicolas Wentzensen (N)

Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute USA, Rockville, MD, USA.

Lynne R Wilkens (LR)

Cancer Center, University of Hawaii, Honolulu, HI, USA.

Alicja Wolk (A)

Institute of Environmental Medicine, Unit of Cardiovascular and Nutritional Epidemiology, Karolinska Institute, Stockholm, Sweden; Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.

Herbert Yu (H)

Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA.

Marian L Neuhouser (ML)

Cancer Prevention Program, Division of Public Health Science, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Dietary omega-3 fatty acids and endometrial...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études prospectives › Dietary omega-3 fatty acids and endometrial...
questionsmedicales.fr › Phénomènes physiologiques › Constitution physique › Apparence corporelle › Surpoids › Dietary omega-3 fatty acids and endometrial...
questionsmedicales.fr › Lipides › Huiles › Huiles de poisson › Acides gras omega-3 › Dietary omega-3 fatty acids and endometrial...
questionsmedicales.fr › Phénomènes physiologiques › Alimentation et nutrition › Phénomènes physiologiques nutritionnels › Régime alimentaire › Dietary omega-3 fatty acids and endometrial...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Obésité › Dietary omega-3 fatty acids and endometrial...
questionsmedicales.fr › Maladies urogénitales › Tumeurs de l'appareil urogénital › Tumeurs de l'appareil génital féminin › Tumeurs de l'utérus › Tumeurs de l'endomètre › Dietary omega-3 fatty acids and endometrial...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Analyse de régression › Modèles logistiques › Dietary omega-3 fatty acids and endometrial...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › Dietary omega-3 fatty acids and endometrial...