Association between periodontal diseases and cardiovascular diseases, diabetes and respiratory diseases: Consensus report of the Joint Workshop by the European Federation of Periodontology (EFP) and the European arm of the World Organization of Family Doctors (WONCA Europe).
cardiovascular diseases
diabetes
family doctors
periodontitis
respiratory diseases
Journal
Journal of clinical periodontology
ISSN: 1600-051X
Titre abrégé: J Clin Periodontol
Pays: United States
ID NLM: 0425123
Informations de publication
Date de publication:
06 2023
06 2023
Historique:
revised:
03
03
2023
received:
19
12
2022
accepted:
10
03
2023
medline:
16
5
2023
pubmed:
20
3
2023
entrez:
19
3
2023
Statut:
ppublish
Résumé
To explore the implications for dentists and family doctors of the association between periodontal and systemic diseases and the role of dentists and family doctors in managing non-communicable diseases (NCDs) and promoting healthy lifestyles. The consensus reports of the previous Focused Workshops on the associations between periodontitis and diabetes (2017) and periodontitis and cardiovascular diseases (2019) formed the technical reviews to underpin discussions on both topics. For the association with respiratory diseases, a systematic review was specifically commissioned for the Workshop discussions. Working groups prepared proposals independently, and then the proposals were discussed and approved at plenary meetings. Periodontitis is independently associated with cardiovascular diseases, diabetes, chronic obstructive pulmonary disease (COPD), obstructive sleep apnea and COVID-19 complications. Dentists and family doctors should collaborate in managing NCDs, implementing strategies for early detection of periodontitis in primary care centres and of cardiovascular diseases or diabetes in dental settings. Family doctors should be informed about periodontal diseases and their consequences, and oral health professionals (OHPs) should be informed about the relevance of NCDs and the associated risk factors. Closer collaboration between OHPs and family doctors is important in the early detection and management of NCDs and in promoting healthy lifestyles. Pathways for early case detection of periodontitis in family medicine practices and of NCDs in dental practices should be developed and evaluated.
Types de publication
Systematic Review
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
819-841Informations de copyright
© 2023 The Authors. Journal of Clinical Periodontology published by John Wiley & Sons Ltd.
Références
Aarabi, G., Zeller, T., Seedorf, H., Reissmann, D. R., Heydecke, G., Schaefer, A. S., & Seedorf, U. (2017). Genetic susceptibility contributing to periodontal and cardiovascular Disease. Journal of Dental Research, 96(6), 610-617. https://doi.org/10.1177/0022034517699786
Alemany, A., Perez-Zsolt, D., Raich-Regue, D., Munoz-Basagoiti, J., Ouchi, D., Laporte-Villar, C., Baro, B., Henriquez, N., Prat, N., Gianinetto, M. O., Gutierrez, M. V., Sanchez-Paniagua, M. G., Henriquez, N. L., Vicente, J. M., Ara, J., Rodriguez-Arias, M. A., Puig, J., Blanco, I., Lopez, C. C., … Mitja, O. (2022). Cetylpyridinium chloride mouthwash to reduce shedding of infectious SARS-CoV-2: A double-blind randomized clinical trial. Journal of Dental Research, 220345221102310, 1450-1456. https://doi.org/10.1177/00220345221102310
Al-Harthi, L. S., Cullinan, M. P., Leichter, J. W., & Thomson, W. M. (2013). The impact of periodontitis on oral health-related quality of life: A review of the evidence from observational studies. Australian Dental Journal, 58(3), 274-277; quiz 384. https://doi.org/10.1111/adj.12076
Allen, E. M., Matthews, J. B., O'Halloran, D. J., Griffiths, H. R., & Chapple, I. L. (2011). Oxidative and inflammatory status in type 2 diabetes patients with periodontitis. Journal of Clinical Periodontology, 38(10), 894-901. https://doi.org/10.1111/j.1600-051X.2011.01764.x
American Thoracic Society. (2018). Oral Appliances for Sleep Apnea in Adults. Retrieved from https://www.thoracic.org/patients/patient-resources/resources/oral-appliances-sleep-apnea.pdf
Awano, S., Ansai, T., Takata, Y., Soh, I., Akifusa, S., Hamasaki, T., Yoshida, A., Sonoki, K., Fujisawa, K., & Takehara, T. (2008). Oral health and mortality risk from pneumonia in the elderly. Journal of Dental Research, 87(4), 334-339. https://doi.org/10.1177/154405910808700418
Baldomero, A. K., Siddiqui, M., Lo, C. Y., Petersen, A., Pragman, A. A., Connett, J. E., Kunisaki, K. M., & Wendt, C. H. (2019). The relationship between oral health and COPD exacerbations. International Journal of Chronic Obstructive Pulmonary Disease, 14, 881-892. https://doi.org/10.2147/copd.S194991
Barros, S. P., Suruki, R., Loewy, Z. G., Beck, J. D., & Offenbacher, S. (2013). A cohort study of the impact of tooth loss and periodontal disease on respiratory events among COPD subjects: Modulatory role of systemic biomarkers of inflammation. PLoS One, 8(8), e68592. https://doi.org/10.1371/journal.pone.0068592
Barrueco, A. S., Mateos-Moreno, M. V., Martinez-Beneyto, Y., Garcia-Vazquez, E., Gonzalez, A. C., Ferrero, J. Z., Castano, A. B., Rueda, I. A., Villacampa Auba, J. M., Espanol, C. C., Moreno-Parrado, L., Ausina-Marquez, V., Garcia-Esteban, S., Artacho, A., Xavier Lopez-Labrador, F., Mira, A., & Ferrer, M. D. (2022). Effect of Oral antiseptics in reducing SARS-CoV-2 infectivity: Evidence from a randomized double-blind clinical trial. Emerging Microbes & Infections, 1-23, 1833-1842. https://doi.org/10.1080/22221751.2022.2098059
Bernabe, E., Marcenes, W., Hernandez, C. R., Bailey, J., Abreu, L. G., Alipour, V., Amini, S., Arabloo, J., Arefi, Z., Arora, A., Ayanore, M. A., Bärnighausen, T. W., Bijani, A., Cho, D. Y., Chu, D. T., Crowe, C. S., Demoz, G. T., Demsie, D. G., Dibaji Forooshani, Z. S., … Kassebaum, N. J. (2020). Global, regional, and National Levels and trends in burden of Oral conditions from 1990 to 2017: A systematic analysis for the global burden of Disease 2017 study. Journal of Dental Research, 99(4), 362-373. https://doi.org/10.1177/0022034520908533
Björnberg, A., & Phang, A. Y. (2018). Euro health consumer index: 2018 report. Retrieved from https://healthpowerhouse.com/media/EHCI-2018/EHCI-2018-report.pdf
Bohadana, A. B., Nilsson, F., Westin, A., Martinet, N., & Martinet, Y. (2006). Smoking cessation-but not smoking reduction-improves the annual decline in FEV1 in occupationally exposed workers. Respiratory Medicine, 100(8), 1423-1430. https://doi.org/10.1016/j.rmed.2005.11.005
Borgnakke, W. S., Ylostalo, P. V., Taylor, G. W., & Genco, R. J. (2013). Effect of periodontal disease on diabetes: Systematic review of epidemiologic observational evidence. Journal of Periodontology, 84(4 Suppl), S135-S152. https://doi.org/10.1902/jop.2013.1340013
Borrell, L. N., Kunzel, C., Lamster, I., & Lalla, E. (2007). Diabetes in the dental office: Using NHANES III to estimate the probability of undiagnosed disease. Journal of Periodontal Research, 42(6), 559-565. https://doi.org/10.1111/j.1600-0765.2007.00983.x
Bould, K., Scott, S. E., Dunne, S., & Asimakopoulou, K. (2017). Uptake of screening for type 2 diabetes risk in general dental practice; an exploratory study. British Dental Journal, 222(4), 293-296. https://doi.org/10.1038/sj.bdj.2017.174
Buset, S. L., Walter, C., Friedmann, A., Weiger, R., Borgnakke, W. S., & Zitzmann, N. U. (2016). Are periodontal diseases really silent? A systematic review of their effect on quality of life. Journal of Clinical Periodontology, 43(4), 333-344. https://doi.org/10.1111/jcpe.12517
Caton, J. G., Armitage, G., Berglundh, T., Chapple, I. L. C., Jepsen, S., Kornman, K. S., Mealey, B. L., Papapanou, P. N., Sanz, M., & Tonetti, M. S. (2018). A new classification scheme for periodontal and peri-implant diseases and conditions - introduction and key changes from the 1999 classification. Journal of Clinical Periodontology, 45(Suppl 20), S1-S8. https://doi.org/10.1111/jcpe.12935
Ceriello, A., Esposito, K., Piconi, L., Ihnat, M. A., Thorpe, J. E., Testa, R., Boemi, M. & Giugliano, D. (2008). Oscillating glucose is more deleterious to endothelial function and oxidative stress than mean glucose in normal and type 2 diabetic patients. Diabetes, 57(5), 1349-1354. https://doi.org/10.2337/db08-0063
Chandy, S., Joseph, K., Sankaranarayanan, A., Issac, A., Babu, G., Wilson, B., & Joseph, J. (2017). Evaluation of C-reactive protein and fibrinogen in patients with Chronic and aggressive periodontitis: A Clinico-biochemical study. Journal of Clinical and Diagnostic Research, 11(3), ZC41-ZC45. https://doi.org/10.7860/JCDR/2017/23100.9552
Chapple, I. L., Genco, R., & Working group 2 of joint EFP & AAP workshop. (2013). Diabetes and periodontal diseases: Consensus report of the joint EFP/AAP workshop on periodontitis and systemic Diseases. Journal of Clinical Periodontology, 40(Suppl 14), S106-S112. https://doi.org/10.1111/jcpe.12077
Chapple, I. L., Van der Weijden, F., Doerfer, C., Herrera, D., Shapira, L., Polak, D., Madianos, P., Louropoulou, A., Machtei, E., Donos, N., Greenwell, H., Van Winkelhoff, A. J., Eren Kuru, B., Arweiler, N., Teughels, W., Aimetti, M., Molina, A., Montero, E., & Graziani, F. (2015). Primary prevention of periodontitis: Managing gingivitis. Journal of Clinical Periodontology, 42(Suppl 16), S71-S76. https://doi.org/10.1111/jcpe.12366
Chen, M. X., Zhong, Y. J., Dong, Q. Q., Wong, H. M., & Wen, Y. F. (2021). Global, regional, and national burden of severe periodontitis, 1990-2019: An analysis of the global burden of Disease study 2019. Journal of Clinical Periodontology, 48(9), 1165-1188. https://doi.org/10.1111/jcpe.13506
Chou, S. H., Tung, Y. C., Lin, Y. S., Wu, L. S., Lin, C. P., Liou, E. J., … Chu, P. H. (2015). Major adverse cardiovascular events in treated periodontitis: A population-based follow-up study from Taiwan. PLoS One, 10(6), e0130807. https://doi.org/10.1371/journal.pone.0130807
Collins, G. S., Ogundimu, E. O., & Altman, D. G. (2016). Sample size considerations for the external validation of a multivariable prognostic model: A resampling study. Statistics in Medicine, 35(2), 214-226. https://doi.org/10.1002/sim.6787
Costa, F. O., Miranda Cota, L. O., Pereira Lages, E. J., Soares Dutra Oliveira, A. M., Dutra Oliveira, P. A., Cyrino, R. M., Medeiros Lorentz, T. C., Cortelli, S. C., & Cortelli, J. R. (2013). Progression of periodontitis and tooth loss associated with glycemic control in individuals undergoing periodontal maintenance therapy: A 5-year follow-up study. Journal of Periodontology, 84(5), 595-605. https://doi.org/10.1902/jop.2012.120255
Creanor, S., Millward, B. A., Demaine, A., Price, L., Smith, W., Brown, N., & Creanor, S. L. (2014). Patients' attitudes towards screening for diabetes and other medical conditions in the dental setting. British Dental Journal, 216(1), E2. https://doi.org/10.1038/sj.bdj.2013.1247
D'Aiuto, F., Gkranias, N., Bhowruth, D., Khan, T., Orlandi, M., Suvan, J., Masi, S., Tsakos, G., Hurel, S., Hingorani, A. D., Donos, N., Deanfield, J. E., & Taste Group. (2018). Systemic effects of periodontitis treatment in patients with type 2 diabetes: A 12 month, single-Centre, investigator-masked, randomised trial. The Lancet Diabetes and Endocrinology, 6(12), 954-965. https://doi.org/10.1016/S2213-8587(18)30038-X
De Melo Neto, J. P., Melo, M. S. A. E., Dos Santos-Pereira, S. A., Martinez, E. F., Okajima, L. S., & Saba-Chujfi, E. (2013). Periodontal infections and community-acquired pneumonia: A case-control study. European Journal of Clinical Microbiology and Infectious Diseases, 32(1), 27-32. https://doi.org/10.1007/s10096-012-1710-y
de Oliveira, C., Watt, R., & Hamer, M. (2010). Toothbrushing, inflammation, and risk of cardiovascular disease: Results from Scottish health survey. BMJ, 340, c2451. https://doi.org/10.1136/bmj.c2451
Del Pinto, R., Landi, L., Grassi, G., Sforza, N. M., Cairo, F., Citterio, F., Paolantoni, G., D'Aiuto, F., Ferri, C., Monaco, A., Pietropaoli, D. & Italian working group on Hypertension and Periodontitis. (2021). Hypertension and periodontitis: A joint report by the Italian Society of Hypertension (SIIA) and the Italian Society of Periodontology and Implantology (SIdP). High Blood Pressure & Cardiovascular Prevention, 28(5), 427-438. https://doi.org/10.1007/s40292-021-00466-6
Del Pinto, R., Pietropaoli, D., Munoz-Aguilera, E., D'Aiuto, F., Czesnikiewicz-Guzik, M., Monaco, A., Guzik, T. J., & Ferri, C. (2020). Periodontitis and hypertension: Is the association causal? High Blood Pressure & Cardiovascular Prevention, 27(4), 281-289. https://doi.org/10.1007/s40292-020-00392-z
Demmer, R. T., Holtfreter, B., Desvarieux, M., Jacobs, D. R., Jr., Kerner, W., Nauck, M., Volzke, H., & Kocher, T. (2012). The influence of type 1 and type 2 diabetes on periodontal disease progression: Prospective results from the study of health in Pomerania (SHIP). Diabetes Care, 35(10), 2036-2042. https://doi.org/10.2337/dc11-2453
Desvarieux, M., Demmer, R. T., Rundek, T., Boden-Albala, B., Jacobs, D. R., Jr., Sacco, R. L., & Papapanou, P. N. (2005). Periodontal microbiota and carotid intima-media thickness: The Oral infections and vascular Disease epidemiology study (INVEST). Circulation, 111(5), 576-582. https://doi.org/10.1161/01.CIR.0000154582.37101.15
Dietrich, T., Sharma, P., Walter, C., Weston, P., & Beck, J. (2013). The epidemiological evidence behind the association between periodontitis and incident atherosclerotic cardiovascular disease. Journal of Clinical Periodontology, 40(Suppl 14), S70-S84. https://doi.org/10.1111/jcpe.12062
Duarte, P. M., Santos, V. R., Dos Santos, F. A., de Lima Pereira, S. A., Rodrigues, D. B., & Napimoga, M. H. (2011). Role of smoking and type 2 diabetes in the immunobalance of advanced chronic periodontitis. Journal of Periodontology, 82(3), 429-438. https://doi.org/10.1902/jop.2010.100215
Economist Intelligence Unit. (2021). Time to take gum disease seriously. The societal and economic impact of periodontitis. Retrieved from https://impact.economist.com/perspectives/sites/default/files/eiu-efp-oralb-gum-disease.pdf
Eke, P. I., Borgnakke, W. S., & Genco, R. J. (2020). Recent epidemiologic trends in periodontitis in the USA. Periodontology 2000, 82(1), 257-267. https://doi.org/10.1111/prd.12323
Eke, P. I., Thornton-Evans, G. O., Wei, L., Borgnakke, W. S., Dye, B. A., & Genco, R. J. (2018). Periodontitis in US adults: National Health and nutrition examination survey 2009-2014. Journal of the American Dental Association (1939), 149(7), 576-588 e576. https://doi.org/10.1016/j.adaj.2018.04.023
Engebretson, S. P., & Kocher, T. (2013). Evidence that periodontal treatment improves diabetes outcomes: A systematic review and meta-analysis. Journal of Clinical Periodontology, 40(Suppl 14), S153-S163. https://doi.org/10.1111/jcpe.12084
Engebretson, S. P., Vossughi, F., Hey-Hadavi, J., Emingil, G., & Grbic, J. T. (2006). The influence of diabetes on gingival crevicular fluid beta-glucuronidase and interleukin-8. Journal of Clinical Periodontology, 33(11), 784-790. https://doi.org/10.1111/j.1600-051X.2006.00984.x
Engstrom, S., Berne, C., Gahnberg, L., & Svardsudd, K. (2013). Effectiveness of screening for diabetes mellitus in dental health care. Diabetic Medicine, 30(2), 239-245. https://doi.org/10.1111/dme.12009
Esmeili, T., Ellison, J., & Walsh, M. M. (2010). Dentists' attitudes and practices related to diabetes in the dental setting. Journal of Public Health Dentistry, 70(2), 108-114. https://doi.org/10.1111/j.1752-7325.2009.00150.x
Esposito, K., Ciotola, M., Carleo, D., Schisano, B., Sardelli, L., Di Tommaso, D., Misso, L., Saccomanno, F., Ceriello, A., & Giugliano, D. (2008). Post-meal glucose peaks at home associate with carotid intima-media thickness in type 2 diabetes. The Journal of Clinical Endocrinology and Metabolism, 93(4), 1345-1350. https://doi.org/10.1210/jc.2007-2000
Garcia, R. I., Krall, E. A., & Vokonas, P. S. (1998). Periodontal disease and mortality from all causes in the VA dental longitudinal study. Annals of Periodontology, 3(1), 339-349. https://doi.org/10.1902/annals.1998.3.1.339
GBD 2015 Chronic Respiratory Disease Collaborators. (2017). Global, regional, and national deaths, prevalence, disability-adjusted life years, and years lived with disability for chronic obstructive pulmonary disease and asthma, 1990-2015: A systematic analysis for the global burden of Disease study 2015. The Lancet Respiratory Medicine, 5(9), 691-706. https://doi.org/10.1016/s2213-2600(17)30293-x
GBD 2017 Disease and Injury Incidence and Prevalence Collaborators. (2018). Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: A systematic analysis for the global burden of Disease study 2017. Lancet, 392(10159), 1789-1858. https://doi.org/10.1016/S0140-6736(18)32279-7
GBD 2019 Diseases and Injuries Collaborators. (2020). Global burden of 369 diseases and injuries in 204 countries and territories, 1990-2019: A systematic analysis for the global burden of Disease study 2019. Lancet, 396(10258), 1204-1222. https://doi.org/10.1016/s0140-6736(20)30925-9
GBD DALYs and Hale Collaborators. (2018). Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2017: A systematic analysis for the global burden of Disease study 2017. Lancet, 392(10159), 1859-1922. https://doi.org/10.1016/S0140-6736(18)32335-3
Genco, R. J., & Borgnakke, W. S. (2020). Diabetes as a potential risk for periodontitis: Association studies. Periodontology 2000, 83(1), 40-45. https://doi.org/10.1111/prd.12270
Genco, R. J., Graziani, F., & Hasturk, H. (2020). Effects of periodontal disease on glycemic control, complications, and incidence of diabetes mellitus. Periodontology 2000, 83(1), 59-65. https://doi.org/10.1111/prd.12271
Genco, R. J., & Sanz, M. (2020). Clinical and public health implications of periodontal and systemic diseases: An overview. Periodontology 2000, 83(1), 7-13. https://doi.org/10.1111/prd.12344
Genco, R. J., Schifferle, R. E., Dunford, R. G., Falkner, K. L., Hsu, W. C., & Balukjian, J. (2014). Screening for diabetes mellitus in dental practices: A field trial. Journal of the American Dental Association (1939), 145(1), 57-64. https://doi.org/10.14219/jada.2013.7
Gottlieb, D. J., Sparrow, D., O'Connor, G. T., & Weiss, S. T. (1996). Skin test reactivity to common aeroallergens and decline of lung function. The normative aging study. American Journal of Respiratory and Critical Care Medicine, 153(2), 561-566. https://doi.org/10.1164/ajrccm.153.2.8564098
Grant, M. M., Taylor, J. J., Jaedicke, K., Creese, A., Gowland, C., Burke, B., Doudin, K., Patel, U., Weston, P., Milward, M., Bissett, S. M., Cooper, H. J., Kooijman, G., Rmaile, A., de Jager, M., Preshaw, P. M., & Chapple, I. L. C. (2022). Discovery, validation, and diagnostic ability of multiple protein-based biomarkers in saliva and gingival crevicular fluid to distinguish between health and periodontal diseases. Journal of Clinical Periodontology, 49(7), 622-632. https://doi.org/10.1111/jcpe.13630
Graziani, F., Gennai, S., Solini, A., & Petrini, M. (2018). A systematic review and meta-analysis of epidemiologic observational evidence on the effect of periodontitis on diabetes an update of the EFP-AAP review. Journal of Clinical Periodontology, 45(2), 167-187. https://doi.org/10.1111/jcpe.12837
Greenberg, B. L., Kantor, M. L., & Bednarsh, H. (2017). American dental hygienists' attitudes towards chairside medical screening in a dental setting. International Journal of Dental Hygiene, 15(4), e61-e68. https://doi.org/10.1111/idh.12217
Greenberg, B. L., Thomas, P. A., Glick, M., & Kantor, M. L. (2015). Physicians' attitudes toward medical screening in a dental setting. Journal of Public Health Dentistry, 75(3), 225-233. https://doi.org/10.1111/jphd.12093
Greenblatt, A. P., Estrada, I., Schrimshaw, E. W., Metcalf, S. S., Kunzel, C., & Northridge, M. E. (2017). Acceptability of chairside screening for racial/ethnic minority older adults: A qualitative study. JDR Clinical & Translational Research, 2(4), 343-352. https://doi.org/10.1177/2380084417716880
Gupta, S., Mohindra, R., Singla, M., Khera, S., Sahni, V., Kanta, P., Soni, R. K., Kumar, A., Gauba, K., Goyal, K., Singh, M. P., Ghosh, A., Kajal, K., Mahajan, V., Bhalla, A., Sorsa, T., & Räisänen, I. (2021). The clinical association between periodontitis and COVID-19. Clinical Oral Investigations, 26, 1361-1374. https://doi.org/10.1007/s00784-021-04111-3
Gustafsson, N., Ahlqvist, J., Naslund, U., Buhlin, K., Gustafsson, A., Kjellstrom, B., Klinge, B., Ryden, L., & Levring Jaghagen, E. (2020). Associations among periodontitis, calcified carotid artery Atheromas, and risk of myocardial infarction. Journal of Dental Research, 99(1), 60-68. https://doi.org/10.1177/0022034519885362
Hajishengallis, G. (2022). Interconnection of periodontal disease and comorbidities: Evidence, mechanisms, and implications. Periodontology 2000, 89(1), 9-18. https://doi.org/10.1111/prd.12430
Hajishengallis, G., & Chavakis, T. (2021). Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities. Nature Reviews. Immunology, 21(7), 426-440. https://doi.org/10.1038/s41577-020-00488-6
Hajishengallis, G., & Lamont, R. J. (2021). Polymicrobial communities in periodontal disease: Their quasi-organismal nature and dialogue with the host. Periodontology 2000, 86(1), 210-230. https://doi.org/10.1111/prd.12371
Hasegawa, A., Sato, T., Hoshikawa, Y., Ishida, N., Tanda, N., Kawamura, Y., Kondo, T., & Takahashi, N. (2014). Detection and identification of oral anaerobes in intraoperative bronchial fluids of patients with pulmonary carcinoma. Microbiology and Immunology, 58(7), 375-381. https://doi.org/10.1111/1348-0421.12157
Heji, E. S., Bukhari, A. A., Bahammam, M. A., Homeida, L. A., Aboalshamat, K. T., & Aldahlawi, S. A. (2021). Periodontal Disease as a predictor of undiagnosed diabetes or prediabetes in dental patients. The European Journal of Dentistry, 15(2), 216-221. https://doi.org/10.1055/s-0040-1719208
Herrera, D., Molina, A., Buhlin, K., & Klinge, B. (2020). Periodontal diseases and association with atherosclerotic disease. Periodontology 2000, 83(1), 66-89. https://doi.org/10.1111/prd.12302
Herrera, D., Sanz, M., Kebschull, M., Jepsen, S., Sculean, A., Berglundh, T., Papapanou, P. N., Chapple, I., Tonetti, M. S., EFP Workshop Participants & Methodological Consultant. (2022). Treatment of stage IV periodontitis: The EFP S3 level clinical practice guideline. Journal of Clinical Periodontology, 49(Suppl 24), 4-71. https://doi.org/10.1111/jcpe.13639
Imai, K., Iinuma, T., & Sato, S. (2021). Relationship between the oral cavity and respiratory diseases: Aspiration of oral bacteria possibly contributes to the progression of lower airway inflammation. Japanese Dental Science Review, 57, 224-230. https://doi.org/10.1016/j.jdsr.2021.10.003
International Diabetes Federation. (2021). IDF Diabetes Atlas 2021 - 10th edition. Retrieved from www.diabetesatlas.org
Jeffcoat, M. K., Jeffcoat, R. L., Gladowski, P. A., Bramson, J. B., & Blum, J. J. (2014). Impact of periodontal therapy on general health: Evidence from insurance data for five systemic conditions. American Journal of Preventive Medicine, 47(2), 166-174. https://doi.org/10.1016/j.amepre.2014.04.001
Jepsen, S., Suvan, J., & Deschner, J. (2020). The association of periodontal diseases with metabolic syndrome and obesity. Periodontology 2000, 83(1), 125-153. https://doi.org/10.1111/prd.12326
Kassebaum, N. J., Bernabe, E., Dahiya, M., Bhandari, B., Murray, C. J., & Marcenes, W. (2014). Global burden of severe periodontitis in 1990-2010: A systematic review and meta-regression. Journal of Dental Research, 93(11), 1045-1053. https://doi.org/10.1177/0022034514552491
Kassebaum, N. J., Smith, A. G. C., Bernabe, E., Fleming, T. D., Reynolds, A. E., Vos, T., Murray, C. J. L., Marcenes, W., & GBD Oral Health Collaborators. (2017). Global, regional, and National Prevalence, Incidence, and disability-adjusted life years for Oral conditions for 195 countries, 1990-2015: A systematic analysis for the global burden of Diseases, Injuries, and risk factors. Journal of Dental Research, 96(4), 380-387. https://doi.org/10.1177/0022034517693566
Kucukcoskun, M., Baser, U., Oztekin, G., Kiyan, E., & Yalcin, F. (2013). Initial periodontal treatment for prevention of chronic obstructive pulmonary disease exacerbations. Journal of Periodontology, 84(7), 863-870. https://doi.org/10.1902/jop.2012.120399
Lalla, E., Cheng, B., Kunzel, C., Burkett, S., Ferraro, A., & Lamster, I. B. (2015). Six-month outcomes in dental patients identified with hyperglycaemia: A randomized clinical trial. Journal of Clinical Periodontology, 42(3), 228-235. https://doi.org/10.1111/jcpe.12358
Lalla, E., Kunzel, C., Burkett, S., Cheng, B., & Lamster, I. B. (2011). Identification of unrecognized diabetes and pre-diabetes in a dental setting. Journal of Dental Research, 90(7), 855-860. https://doi.org/10.1177/0022034511407069
Larvin, H., Wilmott, S., Kang, J., Aggarwal, V. R., Pavitt, S., & Wu, J. (2021). Additive effect of periodontal Disease and obesity on COVID-19 outcomes. Journal of Dental Research, 100(11), 1228-1235. https://doi.org/10.1177/00220345211029638
Linden, G. J., & Herzberg, M. C. (2013). Periodontitis and systemic diseases: A record of discussions of working group 4 of the joint EFP/AAP workshop on periodontitis and systemic Diseases. Journal of Periodontology, 84(4 Suppl), S20-S23. https://doi.org/10.1902/jop.2013.1340020
Linden, G. J., Linden, K., Yarnell, J., Evans, A., Kee, F., & Patterson, C. C. (2012). All-cause mortality and periodontitis in 60-70-year-old men: A prospective cohort study. Journal of Clinical Periodontology, 39(10), 940-946. https://doi.org/10.1111/j.1600-051X.2012.01923.x
Ling, M. R., Chapple, I. L., & Matthews, J. B. (2016). Neutrophil superoxide release and plasma C-reactive protein levels pre- and post-periodontal therapy. Journal of Clinical Periodontology, 43(8), 652-658. https://doi.org/10.1111/jcpe.12575
Liu, Z., Zhang, W., Zhang, J., Zhou, X., Zhang, L., Song, Y., & Wang, Z. (2012). Oral hygiene, periodontal health and chronic obstructive pulmonary disease exacerbations. Journal of Clinical Periodontology, 39(1), 45-52. https://doi.org/10.1111/j.1600-051X.2011.01808.x
Lokke, A., Lange, P., Scharling, H., Fabricius, P., & Vestbo, J. (2006). Developing COPD: A 25 year follow up study of the general population. Thorax, 61(11), 935-939. https://doi.org/10.1136/thx.2006.062802
Loos, B. G., & Van Dyke, T. E. (2020). The role of inflammation and genetics in periodontal disease. Periodontology 2000, 83(1), 26-39. https://doi.org/10.1111/prd.12297
Madianos, P. N., & Koromantzos, P. A. (2018). An update of the evidence on the potential impact of periodontal therapy on diabetes outcomes. Journal of Clinical Periodontology, 45(2), 188-195. https://doi.org/10.1111/jcpe.12836
Mammen, M. J., Scannapieco, F. A., & Sethi, S. (2020). Oral-lung microbiome interactions in lung diseases. Periodontology 2000, 83(1), 234-241. https://doi.org/10.1111/prd.12301
Marouf, N., Cai, W., Said, K. N., Daas, H., Diab, H., Chinta, V. R., Hssain, A. A., Nicolau, B., Sanz, M., & Tamimi, F. (2021). Association between periodontitis and severity of COVID-19 infection: A case-control study. Journal of Clinical Periodontology, 48(4), 483-491. https://doi.org/10.1111/jcpe.13435
Matthews, J. B., Wright, H. J., Roberts, A., Cooper, P. R., & Chapple, I. L. (2007). Hyperactivity and reactivity of peripheral blood neutrophils in chronic periodontitis. Clinical and Experimental Immunology, 147(2), 255-264. https://doi.org/10.1111/j.1365-2249.2006.03276.x
Meyle, J., & Chapple, I. (2015). Molecular aspects of the pathogenesis of periodontitis. Periodontology 2000, 69(1), 7-17. https://doi.org/10.1111/prd.12104
Molina, A., Huck, O., Herrera, D., & Montero, E. (2023). The association between respiratory diseases and periodontitis: A systematic review and meta-analysis. Journal of Clinical Periodontology. Online ahead of print. https://doi.org/10.1111/jcpe.13767
Monje, A., Catena, A., & Borgnakke, W. S. (2017). Association between diabetes mellitus/hyperglycaemia and peri-implant diseases: Systematic review and meta-analysis. Journal of Clinical Periodontology, 44(6), 636-648. https://doi.org/10.1111/jcpe.12724
Montero, E., Herrera, D., Sanz, M., Dhir, S., Van Dyke, T., & Sima, C. (2019). Development and validation of a predictive model for periodontitis using NHANES 2011-2012 data. Journal of Clinical Periodontology, 46(4), 420-429. https://doi.org/10.1111/jcpe.13098
Montero, E., Matesanz, P., Nobili, A., Luis Herrera-Pombo, J., Sanz, M., Guerrero, A., Bujaldon, A., Herrera, D., & Sepa Research Network of Dental Clinics. (2021). Screening of undiagnosed hyperglycaemia in the dental setting: The DiabetRisk study. A Field Trial. Journal of Clinical Periodontology, 48(3), 378-388. https://doi.org/10.1111/jcpe.13408
Munoz Aguilera, E., Suvan, J., Buti, J., Czesnikiewicz-Guzik, M., Barbosa Ribeiro, A., Orlandi, M., Guzik, T. J., Hingorani, A. D., Nart, J., & D'Aiuto, F. (2020). Periodontitis is associated with hypertension: A systematic review and meta-analysis. Cardiovascular Research, 116(1), 28-39. https://doi.org/10.1093/cvr/cvz201
Munz, M., Richter, G. M., Loos, B. G., Jepsen, S., Divaris, K., Offenbacher, S., Teumer, A., Holtfreter, B., Kocher, T., Bruckmann, C., Jockel-Schneider, Y., Graetz, C., Munoz, L., Bhandari, A., Tennstedt, S., Staufenbiel, I., van der Velde, N., Uitterlinden, A. G., de Groot, L., … Schaefer, A. S. (2018). Genome-wide association meta-analysis of coronary artery disease and periodontitis reveals a novel shared risk locus. Scientific Reports, 8(1), 13678. https://doi.org/10.1038/s41598-018-31980-8
National Health Service. (2019). Commissioning standard: Dental Care for People with diabetes.
National Institute for Health and Care Excellence. (2015a). Type 1 diabetes in adults: diagnosis and management (NICE guideline). Retrieved from https://www.nice.org.uk/guidance/ng17/resources/type-1-diabetes-in-adults-diagnosis-and-management-pdf-1837276469701
National Institute for Health and Care Excellence. (2015b). Type 2 diabetes in adults: management (NICE guideline). Retrieved from https://www.nice.org.uk/guidance/ng28/resources/type-2-diabetes-in-adults-management-pdf-1837338615493
National Institute for Health and Care Excellence. (2017). NICE Public Health Guidance [PH38] type 2 diabetes: Encouraging people to have a risk assessment for type 2 diabetes and identifying those at risk. Retrieved from https://www.nice.org.uk/guidance/ph38
National Institute for Health and Care Excellence. (2022). Periodontal treatment to improve diabetic control in adults with type 1 or type 2 diabetes Evidence review D (DRAFT FOR CONSULTATION).
Nguyen, A. T. M., Akhter, R., Garde, S., Scott, C., Twigg, S. M., Colagiuri, S., Ajwani, S., & Eberhard, J. (2020). The association of periodontal disease with the complications of diabetes mellitus. A systematic review. Diabetes Research and Clinical Practice, 165, 108244. https://doi.org/10.1016/j.diabres.2020.108244
Nizam, N., Basoglu, O. K., Tasbakan, M. S., Lappin, D. F., & Buduneli, N. (2016). Is there an association between obstructive sleep apnea syndrome and periodontal inflammation? Clinical Oral Investigations, 20(4), 659-668. https://doi.org/10.1007/s00784-015-1544-y
Orlandi, M., Graziani, F., & D'Aiuto, F. (2020). Periodontal therapy and cardiovascular risk. Periodontology 2000, 83(1), 107-124. https://doi.org/10.1111/prd.12299
Orlandi, M., Munoz Aguilera, E., Marletta, D., Petrie, A., Suvan, J., & D'Aiuto, F. (2022). Impact of the treatment of periodontitis on systemic health and quality of life: A systematic review. Journal of Clinical Periodontology, 49(Suppl 24), 314-327. https://doi.org/10.1111/jcpe.13554
Papapanou, P. N., Sanz, M., Buduneli, N., Dietrich, T., Feres, M., Fine, D. H., Flemmig, T. F., Garcia, R., Giannobile, W. V., Graziani, F., Greenwell, H., Herrera, D., Kao, R. T., Kebschull, M., Kinane, D. F., Kirkwood, K. L., Kocher, T., Kornman, K. S., Kumar, P. S., … Tonetti, M. S. (2018). Periodontitis: Consensus report of workgroup 2 of the 2017 world workshop on the classification of periodontal and Peri-implant Diseases and conditions. Journal of Clinical Periodontology, 45(Suppl 20), S162-S170. https://doi.org/10.1111/jcpe.12946
Park, J. H., Kim, S. H., Kim, S. J., & Kim, J. W. (2022). Recovery from chronic periodontal disease is associated with lower risk for incident diabetes. Journal of Clinical Periodontology, 49, 862-871. https://doi.org/10.1111/jcpe.13687
Park, M. S., Jeon, J., Song, T. J., & Kim, J. (2022). Association of periodontitis with microvascular complications of diabetes mellitus: A nationwide cohort study. Journal of Diabetes and its Complications, 36(2), 108107. https://doi.org/10.1016/j.jdiacomp.2021.108107
Park, S. Y., Kim, S. H., Kang, S. H., Yoon, C. H., Lee, H. J., Yun, P. Y., Youn, T. J., & Chae, I. H. (2019). Improved oral hygiene care attenuates the cardiovascular risk of oral health disease: A population-based study from Korea. European Heart Journal, 40(14), 1138-1145. https://doi.org/10.1093/eurheartj/ehy836
Polak, D., Sanui, T., Nishimura, F., & Shapira, L. (2020). Diabetes as a risk factor for periodontal disease-plausible mechanisms. Periodontology 2000, 83(1), 46-58. https://doi.org/10.1111/prd.12298
Polak, D., & Shapira, L. (2018). An update on the evidence for pathogenic mechanisms that may link periodontitis and diabetes. Journal of Clinical Periodontology, 45(2), 150-166. https://doi.org/10.1111/jcpe.12803
Preshaw, P. M., Taylor, J. J., Jaedicke, K. M., De Jager, M., Bikker, J. W., Selten, W., Bissett, S. M., Whall, K. M., van de Merwe, R., Areibi, A., Jitprasertwong, P., Al-Shahwani, R., Weaver, J., Taylor, R., & Wassall, R. R. (2020). Treatment of periodontitis reduces systemic inflammation in type 2 diabetes. Journal of Clinical Periodontology, 47(6), 737-746. https://doi.org/10.1111/jcpe.13274
Rafferty, B., Jonsson, D., Kalachikov, S., Demmer, R. T., Nowygrod, R., Elkind, M. S., Bush, H., Jr., & Kozarov, E. (2011). Impact of monocytic cells on recovery of uncultivable bacteria from atherosclerotic lesions. Journal of Internal Medicine, 270(3), 273-280. https://doi.org/10.1111/j.1365-2796.2011.02373.x
Reyes, L., Herrera, D., Kozarov, E., Roldan, S., & Progulske-Fox, A. (2013). Periodontal bacterial invasion and infection: Contribution to atherosclerotic pathology. Journal of Clinical Periodontology, 40(Suppl 14), S30-S50. https://doi.org/10.1111/jcpe.12079
Riley, R. D., Ensor, J., Snell, K. I. E., Harrell, F. E., Jr., Martin, G. P., Reitsma, J. B., Moons, K. G. M., Collins, G., & van Smeden, M. (2020). Calculating the sample size required for developing a clinical prediction model. BMJ, 368, m441. https://doi.org/10.1136/bmj.m441
Riley, R. D., Snell, K. I., Ensor, J., Burke, D. L., Harrell, F. E., Jr., Moons, K. G., & Collins, G. S. (2019). Minimum sample size for developing a multivariable prediction model: PART II - binary and time-to-event outcomes. Statistics in Medicine, 38(7), 1276-1296. https://doi.org/10.1002/sim.7992
Roth, G. A., Johnson, C., Abajobir, A., Abd-Allah, F., Abera, S. F., Abyu, G., Ahmed, M., Aksut, B., Alam, T., Alam, K., Alla, F., Alvis-Guzman, N., Amrock, S., Ansari, H., Arnlov, J., Asayesh, H., Atey, T. M., Avila-Burgos, L., Awasthi, A., … Murray, C. (2017). Global, regional, and National Burden of cardiovascular Diseases for 10 causes, 1990 to 2015. Journal of the American College of Cardiology, 70(1), 1-25. https://doi.org/10.1016/j.jacc.2017.04.052
Saeedi, P., Petersohn, I., Salpea, P., Malanda, B., Karuranga, S., Unwin, N., Colagiuri, S., Guariguata, L., Motala, A. A., Ogurtsova, K., Shaw, J. E., Bright, D., Williams, R., & IDF Diabetes Atlas Committee. (2019). Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the international diabetes federation diabetes atlas, 9(th) edition. Diabetes Research and Clinical Practice, 157, 107843. https://doi.org/10.1016/j.diabres.2019.107843
Sanz, M., Ceriello, A., Buysschaert, M., Chapple, I., Demmer, R. T., Graziani, F., Herrera, D., Jepsen, S., Lione, L., Madianos, P., Mathur, M., Montanya, E., Shapira, L., Tonetti, M., & Vegh, D. (2018a). Scientific evidence on the links between periodontal diseases and diabetes: Consensus report and guidelines of the joint workshop on periodontal diseases and diabetes by the international diabetes federation and the European Federation of Periodontology. Journal of Clinical Periodontology, 45(2), 138-149. https://doi.org/10.1111/jcpe.12808
Sanz, M., Ceriello, A., Buysschaert, M., Chapple, I., Demmer, R. T., Graziani, F., Herrera, D., Jepsen, S., Lione, L., Madianos, P., Mathur, M., Montanya, E., Shapira, L., Tonetti, M., & Vegh, D. (2018b). Scientific evidence on the links between periodontal diseases and diabetes: Consensus report and guidelines of the joint workshop on periodontal diseases and diabetes by the international diabetes federation and the European Federation of Periodontology. Diabetes Research and Clinical Practice, 137, 231-241. https://doi.org/10.1016/j.diabres.2017.12.001
Sanz, M., Del Castillo, A. M., Jepsen, S., Gonzalez-Juanatey, J. R., D'Aiuto, F., Bouchard, P., Chapple, I., Dietrich, T., Gotsman, I., Graziani, F., Herrera, D., Loos, B., Madianos, P., Michel, J. B., Perel, P., Pieske, B., Shapira, L., Shechter, M., Tonetti, M., … Wimmer, G. (2020). Periodontitis and cardiovascular Diseases. Consensus Report. Global Heart, 15(1), 1. https://doi.org/10.5334/gh.400
Sanz, M., Herrera, D., Kebschull, M., Chapple, I., Jepsen, S., Berglundh, T., … Methodological Consultants. (2020). Treatment of stage I-III periodontitis-the EFP S3 level clinical practice guideline. Journal of Clinical Periodontology, 47(Suppl 22), 4-60. https://doi.org/10.1111/jcpe.13290
Sanz, M., Marco Del Castillo, A., Jepsen, S., Gonzalez-Juanatey, J. R., D'Aiuto, F., Bouchard, P., Chapple, I., Dietrich, T., Gotsman, I., Graziani, F., Herrera, D., Loos, B., Madianos, P., Michel, J. B., Perel, P., Pieske, B., Shapira, L., Shechter, M., Tonetti, M., … Wimmer, G. (2020). Periodontitis and cardiovascular diseases: Consensus report. Journal of Clinical Periodontology, 47(3), 268-288. https://doi.org/10.1111/jcpe.13189
Sato, M., Iwasaki, M., Yoshihara, A., & Miyazaki, H. (2016). Association between periodontitis and medical expenditure in older adults: A 33-month follow-up study. Geriatrics & Gerontology International, 16(7), 856-864. https://doi.org/10.1111/ggi.12569
Schaefer, A. S., Bochenek, G., Jochens, A., Ellinghaus, D., Dommisch, H., Guzeldemir-Akcakanat, E., Graetz, C., Harks, I., Jockel-Schneider, Y., Weinspach, K., Meyle, J., Eickholz, P., Linden, G. J., Cine, N., Nohutcu, R., Weiss, E., Houri-Haddad, Y., Iraqi, F., Folwaczny, M., … Schreiber, S. (2015). Genetic evidence for PLASMINOGEN as a shared genetic risk factor of coronary artery disease and periodontitis. Circulation. Cardiovascular Genetics, 8(1), 159-167. https://doi.org/10.1161/CIRCGENETICS.114.000554
Schafer, H., Pauleit, D., Sudhop, T., Gouni-Berthold, I., Ewig, S., & Berthold, H. K. (2002). Body fat distribution, serum leptin, and cardiovascular risk factors in men with obstructive sleep apnea. Chest, 122(3), 829-839. https://doi.org/10.1378/chest.122.3.829
Schenkein, H. A., & Loos, B. G. (2013). Inflammatory mechanisms linking periodontal diseases to cardiovascular diseases. Journal of Clinical Periodontology, 40(Suppl 14), S51-S69. https://doi.org/10.1111/jcpe.12060
Schenkein, H. A., Papapanou, P. N., Genco, R., & Sanz, M. (2020). Mechanisms underlying the association between periodontitis and atherosclerotic disease. Periodontology 2000, 83(1), 90-106. https://doi.org/10.1111/prd.12304
Seitz, M. W., Listl, S., Bartols, A., Schubert, I., Blaschke, K., Haux, C., & Van Der Zande, M. M. (2019). Current knowledge on correlations between highly prevalent dental conditions and Chronic Diseases: An umbrella review. Preventing Chronic Disease, 16, E132. https://doi.org/10.5888/pcd16.180641
Sen, S., Giamberardino, L. D., Moss, K., Morelli, T., Rosamond, W. D., Gottesman, R. F., Beck, J., & Offenbacher, S. (2018). Periodontal Disease, regular dental care use, and incident ischemic stroke. Stroke, 49(2), 355-362. https://doi.org/10.1161/STROKEAHA.117.018990
Sharma, P., Dietrich, T., Ferro, C. J., Cockwell, P., & Chapple, I. L. (2016). Association between periodontitis and mortality in stages 3-5 chronic kidney disease: NHANES III and linked mortality study. Journal of Clinical Periodontology, 43(2), 104-113. https://doi.org/10.1111/jcpe.12502
Sheiham, A. (2015). Claims that periodontal treatment reduces costs of treating five systemic conditions are questionable. The Journal of Evidence-Based Dental Practice, 15(1), 35-36. https://doi.org/10.1016/j.jebdp.2015.01.001
Shen, T. C., Chang, P. Y., Lin, C. L., Wei, C. C., Tu, C. Y., Hsia, T. C., Shih, C. M., Hsu, W. H., Sung, F. C., & Kao, C. H. (2017). Impact of periodontal treatment on hospitalization for adverse respiratory events in asthmatic adults: A propensity-matched cohort study. European Journal of Internal Medicine, 46, 56-60. https://doi.org/10.1016/j.ejim.2017.06.005
Simpson, T. C., Clarkson, J. E., Worthington, H. V., MacDonald, L., Weldon, J. C., Needleman, I., Iheozor-Ejiofor, Z., Wild, S. H., Qureshi, A., Walker, A., Patel, V. A., Boyers, D., & Twigg, J. (2022). Treatment of periodontitis for glycaemic control in people with diabetes mellitus. Cochrane Database of Systematic Reviews, 4, CD004714. https://doi.org/10.1002/14651858.CD004714.pub4
Smeets, R., Pfefferle, S., Buttner, H., Knobloch, J. K., & Lutgehetmann, M. (2022). Impact of Oral rinsing with Octenidine based solution on SARS-CoV-2 loads in saliva of infected patients an exploratory study. International Journal of Environmental Research and Public Health, 19(9), 5582. https://doi.org/10.3390/ijerph19095582
Soder, B., Jin, L. J., Klinge, B., & Soder, P. O. (2007). Periodontitis and premature death: A 16-year longitudinal study in a Swedish urban population. Journal of Periodontal Research, 42(4), 361-366. https://doi.org/10.1111/j.1600-0765.2006.00957.x
Solowiej-Wedderburn, J., Ide, M., & Pennington, M. (2017). Cost-effectiveness of non-surgical periodontal therapy for patients with type 2 diabetes in the UK. Journal of Clinical Periodontology, 44(7), 700-707. https://doi.org/10.1111/jcpe.12746
Steyerberg, E. W. (2019). Clinical prediction models: A practical approach to development, validation, and updating. Springer Cham.
Su, N., Teeuw, W. J., Loos, B. G., Kosho, M. X. F., & van der Heijden, G. (2020). Development and validation of a screening model for diabetes mellitus in patients with periodontitis in dental settings. Clinical Oral Investigations, 24(11), 4089-4100. https://doi.org/10.1007/s00784-020-03281-w
Talakey, A. A., Hughes, F., Almoharib, H., Al-Askar, M., & Bernabe, E. (2021). The added value of periodontal measurements for identification of diabetes among Saudi adults. Journal of Periodontology, 92(1), 62-71. https://doi.org/10.1002/JPER.20-0118
Taylor, J. J., Preshaw, P. M., & Lalla, E. (2013). A review of the evidence for pathogenic mechanisms that may link periodontitis and diabetes. Journal of Clinical Periodontology, 40(Suppl 14), S113-S134. https://doi.org/10.1111/jcpe.12059
Teeuw, W. J., Slot, D. E., Susanto, H., Gerdes, V. E., Abbas, F., D'Aiuto, F., Kastelein, J. J., & Loos, B. G. (2014). Treatment of periodontitis improves the atherosclerotic profile: A systematic review and meta-analysis. Journal of Clinical Periodontology, 41(1), 70-79. https://doi.org/10.1111/jcpe.12171
Tonetti, M. S., Jepsen, S., Jin, L., & Otomo-Corgel, J. (2017). Impact of the global burden of periodontal diseases on health, nutrition and wellbeing of mankind: A call for global action. Journal of Clinical Periodontology, 44(5), 456-462. https://doi.org/10.1111/jcpe.12732
Tsai, C., Hayes, C., & Taylor, G. W. (2002). Glycemic control of type 2 diabetes and severe periodontal disease in the US adult population. Community Dentistry and Oral Epidemiology, 30(3), 182-192. https://doi.org/10.1034/j.1600-0528.2002.300304.x
Tuomi, T., Santoro, N., Caprio, S., Cai, M., Weng, J., & Groop, L. (2014). The many faces of diabetes: A disease with increasing heterogeneity. Lancet, 383(9922), 1084-1094. https://doi.org/10.1016/S0140-6736(13)62219-9
World Health Organization. (2021). Cardiovascular Diseases (CVD). Retrieved from https://www.who.int/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds)
World Health Organization (WHO). (2021). Proposed resolution on Oral Health. Retrieved from https://apps.who.int/gb/ebwha/pdf_files/EB148/B148_R1-en.pdf
Wu, X., Chen, J., Xu, M., Zhu, D., Wang, X., Chen, Y., Wu, J., Cui, C., Zhang, W., & Yu, L. (2017). 16S rDNA analysis of periodontal plaque in chronic obstructive pulmonary disease and periodontitis patients. Journal of Oral Microbiology, 9(1), 1324725. https://doi.org/10.1080/20002297.2017.1324725
Yang, L. C., Suen, Y. J., Wang, Y. H., Lin, T. C., Yu, H. C., & Chang, Y. C. (2020). The Association of Periodontal Treatment and Decreased Pneumonia: A Nationwide population-based cohort study. International Journal of Environmental Research and Public Health, 17(1), 356. https://doi.org/10.3390/ijerph17010356
Yang, S., Zhao, L. S., Cai, C., Shi, Q., Wen, N., & Xu, J. (2018). Association between periodontitis and peripheral artery disease: A systematic review and meta-analysis. BMC Cardiovascular Disorders, 18(1), 141. https://doi.org/10.1186/s12872-018-0879-0
Yonel, Z., Batt, J., Jane, R., Cerullo, E., Gray, L. J., Dietrich, T., & Chapple, I. (2020). The role of the Oral healthcare team in identification of type 2 diabetes mellitus: A systematic review. Current Oral Health Reports, 7, 87-97. https://doi.org/10.1007/s40496-020-00250-w
Yonel, Z., Kocher, T., Chapple, I. L. C., Dietrich, T., Volzke, H., Nauck, M., Volzke, H., Nauck, M., Collins, G., Gray, L. J., & Holtfreter, B. (2022). Development and external validation of a multivariable prediction model to identify nondiabetic hyperglycemia and undiagnosed type 2 diabetes: Diabetes risk assessment in dentistry score (DDS). Journal of Dental Research, 220345221129807, 170-177. https://doi.org/10.1177/00220345221129807
Yonel, Z., Sharma, P., Yahyouche, A., Jalal, Z., Dietrich, T., & Chapple, I. L. (2018). Patients' attendance patterns to different healthcare settings and perceptions of stakeholders regarding screening for chronic, non-communicable diseases in high street dental practices and community pharmacy: A cross-sectional study. BMJ Open, 8(11), e024503. https://doi.org/10.1136/bmjopen-2018-024503
Yonel, Z., Yahyouche, A., Jalal, Z., James, A., Dietrich, T., & Chapple, I. L. C. (2020). Patient acceptability of targeted risk-based detection of non-communicable diseases in a dental and pharmacy setting. BMC Public Health, 20(1), 1576. https://doi.org/10.1186/s12889-020-09649-7
Zhou, X., Han, J., Liu, Z., Song, Y., Wang, Z., & Sun, Z. (2014). Effects of periodontal treatment on lung function and exacerbation frequency in patients with chronic obstructive pulmonary disease and chronic periodontitis: A 2-year pilot randomized controlled trial. Journal of Clinical Periodontology, 41(6), 564-572. https://doi.org/10.1111/jcpe.12247