Overview of the structure and function of the dopamine transporter and its protein interactions.
allosteric modulators
dopamine transporter
inward-open
oligomerization
outward-open
post translational modifications
tat
α-synuclein
Journal
Frontiers in physiology
ISSN: 1664-042X
Titre abrégé: Front Physiol
Pays: Switzerland
ID NLM: 101549006
Informations de publication
Date de publication:
2023
2023
Historique:
received:
24
01
2023
accepted:
21
02
2023
entrez:
20
3
2023
pubmed:
21
3
2023
medline:
21
3
2023
Statut:
epublish
Résumé
The dopamine transporter (DAT) plays an integral role in dopamine neurotransmission through the clearance of dopamine from the extracellular space. Dysregulation of DAT is central to the pathophysiology of numerous neuropsychiatric disorders and as such is an attractive therapeutic target. DAT belongs to the solute carrier family 6 (SLC6) class of Na
Identifiants
pubmed: 36935752
doi: 10.3389/fphys.2023.1150355
pii: 1150355
pmc: PMC10020207
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1150355Informations de copyright
Copyright © 2023 Nepal, Das, Reith and Kortagere.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Elife. 2018 Apr 09;7:
pubmed: 29630493
Front Physiol. 2018 May 22;9:576
pubmed: 29872404
J Biol Chem. 1997 Jun 13;272(24):15541-6
pubmed: 9182590
J Biol Chem. 2005 Oct 21;280(42):35617-24
pubmed: 16109712
Nat Chem Biol. 2014 Jul;10(7):582-589
pubmed: 24880859
Annu Rev Pharmacol Toxicol. 2007;47:401-41
pubmed: 17067279
Nature. 2007 Aug 23;448(7156):952-6
pubmed: 17687333
Nat Commun. 2017 Jan 10;8:13877
pubmed: 28072417
Exp Neurol. 1998 Jul;152(1):88-94
pubmed: 9682015
Mol Pharmacol. 2005 Jan;67(1):140-51
pubmed: 15615700
J Neurosci. 2003 Mar 1;23(5):1697-709
pubmed: 12629174
FASEB J. 2001 Apr;15(6):916-26
pubmed: 11292651
Neurobiol Dis. 2009 Dec;36(3):494-508
pubmed: 19766189
J Neuroimmune Pharmacol. 2013 Sep;8(4):975-87
pubmed: 23645138
J Biol Chem. 2011 Mar 11;286(10):8697-8706
pubmed: 21212261
Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1683-8
pubmed: 11818545
C R Acad Sci III. 2000 Oct;323(10):883-94
pubmed: 11098404
J Neurochem. 2010 Aug;114(3):873-85
pubmed: 20492355
J Biol Chem. 2011 Feb 18;286(7):5175-86
pubmed: 21118819
Neurobiol Dis. 2015 Feb;74:325-35
pubmed: 25511804
Nature. 2019 May;569(7754):141-145
pubmed: 31019304
ChemMedChem. 2012 Dec;7(12):2093-100
pubmed: 23060293
Neurochem Res. 2004 Jul;29(7):1405-9
pubmed: 15202772
Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14524-9
pubmed: 12376616
J Neurochem. 1997 Jan;68(1):225-32
pubmed: 8978729
Bioorg Med Chem Lett. 2018 Feb 1;28(3):470-475
pubmed: 29258773
J Neurochem. 2015 Apr;133(2):167-73
pubmed: 25580950
Brain Res Dev Brain Res. 1994 Nov 18;83(1):53-8
pubmed: 7697870
NPJ Parkinsons Dis. 2021 Mar 5;7(1):22
pubmed: 33674612
Proc Natl Acad Sci U S A. 2001 Aug 28;98(18):10055-60
pubmed: 11526230
J Neurochem. 1994 Mar;62(3):998-1008
pubmed: 8113819
J Neuroimmune Pharmacol. 2021 Dec;16(4):854-869
pubmed: 33537927
J Neurochem. 1996 Aug;67(2):593-600
pubmed: 8764584
J Biol Chem. 2011 Dec 23;286(51):43933-43943
pubmed: 21990355
J Neurosci. 2004 Aug 4;24(31):7024-36
pubmed: 15295038
J Biol Chem. 2012 May 25;287(22):18524-34
pubmed: 22451652
J Med Chem. 2011 Apr 28;54(8):2924-32
pubmed: 21446715
Neurosci Lett. 2003 Apr 17;340(3):189-92
pubmed: 12672538
Proc Natl Acad Sci U S A. 2001 Apr 24;98(9):5300-5
pubmed: 11320258
Neurochem Int. 1997 Oct;31(4):607-16
pubmed: 9308011
Trends Pharmacol Sci. 2013 Sep;34(9):489-96
pubmed: 23968642
J Biol Chem. 2013 Sep 20;288(38):27534-27544
pubmed: 23884410
J Clin Invest. 2014 Jul;124(7):3107-20
pubmed: 24911152
Nature. 2005 Sep 8;437(7056):215-23
pubmed: 16041361
J Neurosci. 2004 Mar 31;24(13):3436-43
pubmed: 15056723
J Biol Chem. 2005 Dec 9;280(49):40442-9
pubmed: 16204245
Front Mol Neurosci. 2016 Jun 20;9:48
pubmed: 27378848
Neuropharmacology. 2019 Dec 15;161:107676
pubmed: 31228486
Biochemistry. 2004 May 11;43(18):5539-50
pubmed: 15122920
J Neurosci. 2012 Apr 18;32(16):5385-97
pubmed: 22514303
J Neurochem. 2010 Mar;112(6):1605-18
pubmed: 20067583
Front Behav Neurosci. 2017 Nov 27;11:222
pubmed: 29230168
J Phys Chem B. 2018 May 31;122(21):5336-5346
pubmed: 29232131
Nat Neurosci. 2005 Jul;8(7):881-8
pubmed: 15924135
J Biol Chem. 2002 Jul 12;277(28):25178-86
pubmed: 11994276
ACS Chem Neurosci. 2019 Jun 19;10(6):2707-2717
pubmed: 30965003
Eur J Pharmacol. 1997 Dec 11;340(2-3):249-58
pubmed: 9537821
Mol Pharmacol. 2001 Jan;59(1):83-95
pubmed: 11125028
J Biol Chem. 2003 Jan 24;278(4):2731-9
pubmed: 12429746
Br J Pharmacol. 2002 Dec;137(8):1155-62
pubmed: 12466224
Sci Rep. 2017 Jun 16;7(1):3694
pubmed: 28623359
J Neurochem. 2001 May;77(4):1116-27
pubmed: 11359877
PLoS One. 2013;8(4):e60378
pubmed: 23560093
J Neurochem. 2008 Jun;105(5):1683-99
pubmed: 18248623
Biomedicines. 2021 Jun 02;9(6):
pubmed: 34199621
Neuron. 2001 Apr;30(1):121-34
pubmed: 11343649
J Biol Chem. 2004 May 14;279(20):21012-20
pubmed: 15024013
Nature. 2015 May 21;521(7552):322-7
pubmed: 25970245
Mol Cell Neurosci. 2003 Sep;24(1):91-105
pubmed: 14550771
J Biol Chem. 2015 Dec 4;290(49):29542-54
pubmed: 26442590
Nat Neurosci. 2008 Jul;11(7):780-9
pubmed: 18568020
PLoS One. 2011;6(12):e27959
pubmed: 22163275
Front Cell Neurosci. 2019 Feb 08;13:35
pubmed: 30828290
Traffic. 2005 Feb;6(2):157-70
pubmed: 15634215
Pharmacol Biochem Behav. 2023 Jan;222:173499
pubmed: 36462584
J Neurosci. 2011 May 18;31(20):7264-74
pubmed: 21593311
J Biol Chem. 2014 Oct 24;289(43):29712-27
pubmed: 25179220
Nat Struct Mol Biol. 2015 Jun;22(6):506-508
pubmed: 25961798
J Biol Chem. 2005 Mar 11;280(10):9595-603
pubmed: 15615727
J Neurosci. 2008 Jul 9;28(28):7040-6
pubmed: 18614672
J Med Chem. 2017 Dec 28;60(24):10172-10187
pubmed: 29227643
J Biol Chem. 2021 Jan-Jun;296:100787
pubmed: 34015332
J Pharmacol Exp Ther. 2018 Oct;367(1):119-128
pubmed: 30108161
Proc Natl Acad Sci U S A. 1998 May 26;95(11):6469-73
pubmed: 9600990
Front Neurol. 2015 Jun 09;6:134
pubmed: 26106364
J Neurochem. 2018 Jan;144(2):162-171
pubmed: 29168892
J Biol Chem. 2017 Jan 27;292(4):1302-1309
pubmed: 27986813
J Pharmacol Exp Ther. 1996 Jun;277(3):1527-32
pubmed: 8667219
PLoS Biol. 2004 Mar;2(3):E78
pubmed: 15024426
J Biol Chem. 2008 Jun 20;283(25):17691-701
pubmed: 18426798
J Neurosci. 2002 Jun 1;22(11):4399-405
pubmed: 12040046
Proc Natl Acad Sci U S A. 1988 Jul;85(14):5274-8
pubmed: 2899326
J Neurosci. 2006 Aug 2;26(31):8195-205
pubmed: 16885233
Synapse. 2004 Dec 1;54(3):173-82
pubmed: 15452864
Drug Alcohol Depend. 2015 Feb 1;147:1-19
pubmed: 25548026
Biochem Pharmacol. 2017 Oct 15;142:204-215
pubmed: 28734777
EMBO J. 2007 Apr 18;26(8):2127-36
pubmed: 17380124
Mol Cell Neurosci. 2008 Oct;39(2):211-7
pubmed: 18638559
J Phys Chem B. 2009 Nov 12;113(45):15057-66
pubmed: 19831380
Nature. 1988 Jul 14;334(6178):165-7
pubmed: 3386755
Brain Res. 1994 Mar 28;641(1):83-91
pubmed: 7912635
J Neurochem. 2008 May;105(3):910-20
pubmed: 18088380
J Biol Chem. 2015 Nov 27;290(48):29095-105
pubmed: 26424792
J Biol Chem. 2010 Oct 15;285(42):32616-26
pubmed: 20688912
J Neuroimmune Pharmacol. 2012 Sep;7(3):629-39
pubmed: 22570010
PLoS One. 2011;6(10):e25790
pubmed: 22043293
J Biol Chem. 1999 Dec 24;274(52):36928-34
pubmed: 10601246
J Biol Chem. 2019 Apr 5;294(14):5632-5642
pubmed: 30705091
J Neurochem. 1995 Nov;65(5):2043-9
pubmed: 7595488
Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):11642-7
pubmed: 23798435
Neuroscience. 2010 Oct 13;170(2):408-16
pubmed: 20643191
J Neurochem. 2012 Dec;123(5):700-15
pubmed: 22957537
J Neurosci Res. 2007 Feb 1;85(2):351-63
pubmed: 17131421
Mol Neurobiol. 2011 Aug;44(1):102-10
pubmed: 21717292
J Neurochem. 1998 May;70(5):1941-9
pubmed: 9572278
Nature. 2013 Nov 7;503(7474):85-90
pubmed: 24037379
Sci Rep. 2021 Feb 18;11(1):4164
pubmed: 33602981
J Biol Chem. 2001 Aug 3;276(31):29012-8
pubmed: 11395483
J Biol Chem. 2004 Feb 20;279(8):6650-7
pubmed: 14660642
Science. 2007 Sep 7;317(5843):1390-3
pubmed: 17690258
Eur J Neurosci. 2008 Feb;27(4):947-57
pubmed: 18333965
J Pharmacol Exp Ther. 2011 Apr;337(1):218-25
pubmed: 21228061
J Phys Chem B. 2017 Apr 20;121(15):3657-3666
pubmed: 28118712
Eur J Pharmacol. 1997 Sep 3;334(1):111-4
pubmed: 9346337
ACS Chem Neurosci. 2021 Apr 21;12(8):1406-1418
pubmed: 33844493
J Neurochem. 1999 Jan;72(1):148-56
pubmed: 9886065
ACS Chem Biol. 2013 Sep 20;8(9):1912-7
pubmed: 23844586
Neuropharmacology. 1992 Dec;31(12):1201-10
pubmed: 1361665
ACS Chem Neurosci. 2016 Oct 19;7(10):1406-1417
pubmed: 27425420
J Neurosci. 1998 Dec 15;18(24):10304-9
pubmed: 9852568
PLoS One. 2018 Jul 2;13(7):e0200085
pubmed: 29965988
Structure. 2015 Nov 3;23(11):2171-81
pubmed: 26481814
J Biol Chem. 2003 Nov 14;278(46):45045-8
pubmed: 14519759
J Chem Neuroanat. 2017 Oct;83-84:3-9
pubmed: 28115272
Neuropharmacology. 2005 Nov;49(6):724-36
pubmed: 16171832
ACS Chem Neurosci. 2020 Oct 21;11(20):3214-3232
pubmed: 32991141
Nat Rev Neurosci. 2010 Mar;11(3):161-75
pubmed: 20168314
Neuropsychopharmacology. 2019 Jul;44(8):1435-1444
pubmed: 30858517
J Neurovirol. 2011 Feb;17(1):26-40
pubmed: 21165787
J Biol Chem. 2003 Jul 25;278(30):28274-83
pubmed: 12746456
Retrovirology. 2009 May 25;6:50
pubmed: 19467159
Neuropharmacology. 2005 Nov;49(6):780-90
pubmed: 16216288
ACS Chem Neurosci. 2015 Apr 15;6(4):658-665
pubmed: 25695767
Physiol Rev. 2006 Apr;86(2):669-707
pubmed: 16601271
Brain Res. 1995 Feb 13;671(2):181-6
pubmed: 7743206
Neuropharmacology. 2021 Dec 1;200:108820
pubmed: 34619165
ACS Chem Neurosci. 2013 Feb 20;4(2):295-309
pubmed: 23421681
ACS Med Chem Lett. 2014 Apr 15;5(6):623-7
pubmed: 24944732
J Pharmacol Exp Ther. 2018 Nov;367(2):222-233
pubmed: 30150482
Science. 2010 Sep 24;329(5999):1663-7
pubmed: 20798282
J Neurochem. 2021 May;157(4):919-929
pubmed: 32767560
PLoS One. 2011 Jan 27;6(1):e16350
pubmed: 21298009
J Biol Chem. 2004 Dec 24;279(52):54380-6
pubmed: 15492001
Biophys Chem. 2022 Apr;283:106765
pubmed: 35101818
J Biol Chem. 2012 Aug 24;287(35):29627-35
pubmed: 22778257
J Pharmacol Exp Ther. 2013 Jul;346(1):2-10
pubmed: 23568856
Nat Commun. 2020 Feb 21;11(1):1005
pubmed: 32081981
J Neurosci. 1997 Jul 15;17(14):5255-62
pubmed: 9204909
J Comp Neurol. 1999 Jun 21;409(1):38-56
pubmed: 10363710
Mol Aspects Med. 2013 Apr-Jun;34(2-3):197-219
pubmed: 23506866
Biochim Biophys Acta. 1994 Feb 23;1190(1):185-7
pubmed: 8110814
FASEB J. 2003 Nov;17(14):2151-3
pubmed: 12958153
Mol Pharmacol. 2008 Oct;74(4):1101-8
pubmed: 18617632
Neurology. 2010 Dec 7;75(23):2087-96
pubmed: 21135382
Traffic. 2013 Jun;14(6):709-24
pubmed: 23418867
Neuropharmacology. 2011 Jan;60(1):182-90
pubmed: 20816875
Neurochem Int. 2006 Apr;48(5):329-40
pubmed: 16406146
J Biol Chem. 2017 Nov 17;292(46):19066-19075
pubmed: 28939767
J Neurodev Disord. 2012 Jul 06;4(1):19
pubmed: 22958744
Trends Neurosci. 2011 Jun;34(6):293-303
pubmed: 21592595
J Neurochem. 2003 Jun;85(6):1513-20
pubmed: 12787070
PLoS Comput Biol. 2018 Jun 6;14(6):e1006229
pubmed: 29874235
Ann N Y Acad Sci. 2010 Feb;1187:316-40
pubmed: 20201860
Sci Rep. 2015 Oct 27;5:15650
pubmed: 26503701
J Pharmacol Exp Ther. 2012 Apr;341(1):251-62
pubmed: 22271821
J Biol Chem. 2021 Jan-Jun;296:100430
pubmed: 33610553
Nucleic Acids Res. 1989 May 11;17(9):3551-61
pubmed: 2542902
Mol Psychiatry. 2021 Aug;26(8):4417-4430
pubmed: 31796894
PLoS Comput Biol. 2018 Jan 12;14(1):e1005907
pubmed: 29329285
Mol Biol Cell. 2007 Jan;18(1):313-23
pubmed: 17079728
Mol Pharmacol. 2008 Mar;73(3):813-23
pubmed: 17978168
Sci Rep. 2019 Mar 7;9(1):3843
pubmed: 30846720
J Neurochem. 1999 Mar;72(3):1266-74
pubmed: 10037500
Int J Dev Neurosci. 2002 Jun-Aug;20(3-5):219-24
pubmed: 12175857
Pharmacol Ther. 2018 Mar;183:78-89
pubmed: 28987321
Mol Pharmacol. 1999 Aug;56(2):434-47
pubmed: 10419565
J Neurosci. 1995 Mar;15(3 Pt 1):1714-23
pubmed: 7534339
J Pharmacol Exp Ther. 2009 Jun;329(3):1071-83
pubmed: 19325033
J Chem Inf Model. 2020 Aug 24;60(8):3958-3968
pubmed: 32649824
ACS Chem Neurosci. 2019 Aug 21;10(8):3718-3730
pubmed: 31184115
J Biol Chem. 2004 Jan 30;279(5):3228-38
pubmed: 14597628
Neuropsychopharmacology. 2021 Mar;46(4):699-708
pubmed: 33032296
Nat Commun. 2019 Jun 20;10(1):2714
pubmed: 31221956
J Neurochem. 1994 Dec;63(6):2108-17
pubmed: 7964730
Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6850-5
pubmed: 10823899
J Biol Chem. 2003 Feb 14;278(7):4990-5000
pubmed: 12464618
Curr Comput Aided Drug Des. 2020;16(2):122-133
pubmed: 30514192
Mol Psychiatry. 2013 Dec;18(12):1315-23
pubmed: 23979605
J Neurochem. 2003 Sep;86(5):1247-59
pubmed: 12911632
Front Pharmacol. 2015 Oct 16;6:235
pubmed: 26528185
Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9238-43
pubmed: 9689064
Microbes Infect. 2006 Apr;8(5):1347-57
pubmed: 16697675
Nat Commun. 2017 Jan 19;8:14089
pubmed: 28102201
J Pharmacol Exp Ther. 1997 Sep;282(3):1358-65
pubmed: 9316847
Science. 1995 Oct 13;270(5234):296-9
pubmed: 7569979
Biochem Pharmacol. 1992 May 28;43(10):2189-99
pubmed: 1599505
Synapse. 1997 Jun;26(2):194-8
pubmed: 9131778
J Biol Chem. 2021 Jul;297(1):100863
pubmed: 34118233
J Biol Chem. 1996 Aug 30;271(35):21672-80
pubmed: 8702957
Biochemistry. 2009 Feb 10;48(5):1067-76
pubmed: 19146407
J Physiol. 2014 Mar 1;592(5):863-9
pubmed: 23878376
J Neurosci. 2011 Apr 27;31(17):6605-15
pubmed: 21525301
J Chem Neuroanat. 2017 Oct;83-84:10-18
pubmed: 27836487
Adv Pharmacol. 2018;82:205-234
pubmed: 29413521
Virol J. 2013 Dec 21;10:358
pubmed: 24359561
Synapse. 2011 Nov;65(11):1251-4
pubmed: 21538554
Proteins. 2008 Feb 15;70(3):1033-46
pubmed: 17847094
J Neurosci. 1999 Sep 15;19(18):7699-710
pubmed: 10479674
J Neurochem. 2010 Apr;113(1):27-41
pubmed: 20085610
J Biol Chem. 2012 Aug 24;287(35):29702-12
pubmed: 22722938
Eur J Neurosci. 2008 Dec;28(12):2459-73
pubmed: 19032594
Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):14192-7
pubmed: 18768815
Biophys J. 2018 May 8;114(9):2128-2141
pubmed: 29742406
Nature. 2012 Jan 09;481(7382):469-74
pubmed: 22230955
ACS Chem Neurosci. 2021 May 5;12(9):1519-1527
pubmed: 33886267
J Biol Chem. 1997 Jan 3;272(1):217-21
pubmed: 8995250
PLoS Comput Biol. 2013;9(2):e1002909
pubmed: 23436987
Curr Opin Struct Biol. 2010 Aug;20(4):415-22
pubmed: 20739005
J Neurosci. 2018 Jan 10;38(2):484-497
pubmed: 29175958
J Clin Invest. 2009 Jun;119(6):1595-603
pubmed: 19478460
J Mol Neurosci. 2014 Feb;52(2):167-76
pubmed: 24048740
Synapse. 2003 Aug;49(2):125-33
pubmed: 12740868
J Neurochem. 2005 Jul;94(2):352-9
pubmed: 15998286
J Neurosci. 2016 Jun 15;36(24):6431-44
pubmed: 27307232
Biochemistry. 2004 Feb 10;43(5):1242-53
pubmed: 14756560
J Am Chem Soc. 2013 Sep 25;135(38):14266-75
pubmed: 23980525
Neurosci Lett. 2016 May 27;622:78-82
pubmed: 27113203
Naunyn Schmiedebergs Arch Pharmacol. 1992 Mar;345(3):309-18
pubmed: 1620235
Biol Psychiatry. 2012 Sep 1;72(5):405-13
pubmed: 22537794
Neurosci Lett. 2006 Mar 13;395(3):235-9
pubmed: 16356633
Curr Opin Neurobiol. 1991 Jun;1(1):84-90
pubmed: 1688010
J Biol Chem. 2019 Mar 8;294(10):3419-3431
pubmed: 30587577
Addict Biol. 2022 Nov;27(6):e13241
pubmed: 36301217
J Neurochem. 1994 Nov;63(5):1683-92
pubmed: 7931324
Front Pharmacol. 2015 Sep 29;6:223
pubmed: 26483692
J Biol Chem. 2003 May 30;278(22):20162-70
pubmed: 12660249
Proc Natl Acad Sci U S A. 1998 Jun 23;95(13):7699-704
pubmed: 9636213
Mol Cell. 2008 Jun 20;30(6):667-77
pubmed: 18570870
Pharmacol Ther. 2001 Oct;92(1):21-55
pubmed: 11750035
Neurochem Int. 2008 Jun;52(8):1436-41
pubmed: 18468730
Mol Psychiatry. 2022 Feb;27(2):1031-1046
pubmed: 34650206
J Biol Chem. 1999 Dec 10;274(50):35794-801
pubmed: 10585462