Venturi-based rapid expansion of supercritical solution (Vent-RESS): synthesis of liposomes for pH-triggered delivery of hydrophilic and lipophilic bioactives.
Journal
Green chemistry : an international journal and green chemistry resource : GC
ISSN: 1463-9262
Titre abrégé: Green Chem
Pays: England
ID NLM: 101307052
Informations de publication
Date de publication:
07 Jul 2022
07 Jul 2022
Historique:
entrez:
20
3
2023
pubmed:
21
3
2023
medline:
21
3
2023
Statut:
ppublish
Résumé
Multivitamin-loaded and surface-modified liposomes tailored for simultaneous intestinal delivery of both lipophilic and hydrophilic bioactives were synthesized from sunflower phosphatidylcholine (SFPC). Liposomes (SL) were generated with the aid of a novel, organic solvent free, and environmentally benign process which utilizes venturi-based rapid expansion of supercritical solution (Vent-RESS). Vitamins E and C were used as model lipophilic and hydrophilic bioactives and demonstrated an average encapsulation efficiency of 92 and 70 %, respectively. Synthesized liposomes were coated with a pH-responsive double-wall of chitosan and β-lactoglobulin (βlg-Cs-SL) to develop a biocompatible vehicle for pH-triggered delivery of bioactive cargo(s). To compare the efficacy of this newly developed dual-coating, SL was also coated with a commercially available pH responsive polymer, Eudragit
Identifiants
pubmed: 36935900
doi: 10.1039/d2gc00877g
pmc: PMC10021132
mid: NIHMS1829016
doi:
Types de publication
Journal Article
Langues
eng
Pagination
5326-5337Subventions
Organisme : NCRR NIH HHS
ID : S10 RR025502
Pays : United States
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