Speckle tracking echocardiography-derived parameters as new prognostic markers in hypertrophic cardiomyopathies.
Anderson–Fabry disease
Cardiac arrhythmias
Hypertrophic cardiomyopathy
Mechanical dispersion
Speckle tracking echocardiography
Journal
European heart journal open
ISSN: 2752-4191
Titre abrégé: Eur Heart J Open
Pays: England
ID NLM: 9918282081406676
Informations de publication
Date de publication:
Mar 2023
Mar 2023
Historique:
received:
28
11
2022
revised:
03
02
2023
accepted:
14
02
2023
entrez:
20
3
2023
pubmed:
21
3
2023
medline:
21
3
2023
Statut:
epublish
Résumé
Hypertrophic cardiomyopathies (HCM) are caused in 30-60% of cases by mutations in cardiac sarcomere genes but can also be an expression of cardiac involvement in multi-systemic metabolic diseases, such as Anderson-Fabry disease (AFD). HCM entails a risk of sudden cardiac death (SCD) of 0.9%/year and is the most common cause of SCD in young adults. Recent studies suggested mechanical dispersion (MD) by speckle tracking echocardiography (STE) as an additional arrhythmic risk marker. The aim of the study was to evaluate left ventricle global longitudinal strain (LV-GLS) and MD, in patients with HCM or AFD cardiomyopathy, and the association with ventricular arrhythmias (V-AR). We evaluated 40 patients with HCM, 57 with AFD (12 with LV hypertrophy and 45 without), and 40 healthy subjects, between January 2014 and June 2022. We performed a comprehensive echocardiographic study and analysed systolic and diastolic functions, LV-GLS, and MD. We also analysed V-AR, including ventricular fibrillation and sustained/non-sustained ventricular tachycardia, by Holter electrocardiogram (Holter-EKG), in a subset of hypertrophic patients. Data were analysed by unpaired Student MD is a useful additional index in the evaluation of patients with HCM and may be a promising prognostic predictor of increased arrhythmic risk.
Identifiants
pubmed: 36936390
doi: 10.1093/ehjopen/oead014
pii: oead014
pmc: PMC10019808
doi:
Types de publication
Journal Article
Langues
eng
Pagination
oead014Informations de copyright
© The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology.
Déclaration de conflit d'intérêts
Conflict of interest: None declared.
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