Topoisomerase I poisons-induced autophagy: Cytoprotective, Cytotoxic or Non-protective.
Autophagy
Cytoprotective
Cytotoxic
Irinotecan
Non-protective
Topotecan
Journal
Autophagy reports
ISSN: 2769-4127
Titre abrégé: Autophagy Rep
Pays: United States
ID NLM: 9918383885906676
Informations de publication
Date de publication:
2023
2023
Historique:
pmc-release:
01
01
2024
entrez:
20
3
2023
pubmed:
21
3
2023
medline:
21
3
2023
Statut:
ppublish
Résumé
Topoisomerase I inhibitors represent a widely used class of antineoplastic agents that promote both single-stranded and double-stranded breaks in the DNA of tumor cells, leading to tumor cell death. Topotecan and irinotecan are the clinically relevant derivatives of the parent drug, camptothecin. As is the case with many if not most anticancer agents, irinotecan and topotecan promote autophagy. However, whether the autophagy is cytotoxic, cytoprotective, or non-protective is not clearly defined, and may depend largely upon the genetic background of the tumor cell being investigated. This review explores the available literature regarding the nature of the autophagy induced by these clinically utilized topoisomerase I inhibitors in preclinical tumor models with the goal of determining whether the targeting of autophagy might have potential as a therapeutic strategy to enhance the antitumor response and/or overcome drug resistance.
Identifiants
pubmed: 36936397
doi: 10.1080/27694127.2022.2155904
pmc: PMC10019749
mid: NIHMS1881457
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1-16Subventions
Organisme : NCI NIH HHS
ID : R01 CA239706
Pays : United States
Déclaration de conflit d'intérêts
Conflicts of Interest: The authors declare no conflict of interest.
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