Balance of the prooxidant and antioxidant system is associated with mortality in critically ill patients.
biological antioxidant potential
critically ill patients
modified ratio
mortality
oxidative stress
Journal
Journal of clinical biochemistry and nutrition
ISSN: 0912-0009
Titre abrégé: J Clin Biochem Nutr
Pays: Japan
ID NLM: 8700907
Informations de publication
Date de publication:
Mar 2023
Mar 2023
Historique:
received:
23
07
2022
accepted:
06
11
2022
entrez:
20
3
2023
pubmed:
21
3
2023
medline:
21
3
2023
Statut:
ppublish
Résumé
It is well known that oxidative stress causes certain diseases and organ damage. However, roles of oxidative stress in the acute phase of critical patients remain to be elucidated. This study aimed to investigate the balance of oxidative and antioxidative system and to clarify the association between oxidative stress and mortality in critically ill patients. This cohort study enrolled 247 patients transported to our emergency department by ambulance. Blood was drawn on hospital arrival, and serum derivatives of reactive oxidant metabolites (dROMs, oxidative index) and biological antioxidant potential (BAP, antioxidative index) were measured. Modified ratio (MR) is also calculated as BAP/dROMs/7.51. There were 197 survivors and 50 non-survivors. In the non-survivors, dROMs were significantly lower (274 vs 311,
Identifiants
pubmed: 36936878
doi: 10.3164/jcbn.22-79
pii: DN/JST.JSTAGE/jcbn/22-79
pmc: PMC10017322
doi:
Types de publication
Journal Article
Langues
eng
Pagination
157-164Informations de copyright
Copyright © 2023 JCBN.
Déclaration de conflit d'intérêts
No potential conflicts of interest were disclosed.
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