Endothelial Protein kinase D1 is a major regulator of post-traumatic hyperinflammation.


Journal

Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960

Informations de publication

Date de publication:
2023
Historique:
received: 08 11 2022
accepted: 15 02 2023
entrez: 20 3 2023
pubmed: 21 3 2023
medline: 22 3 2023
Statut: epublish

Résumé

Trauma is a major cause of death worldwide. The post-traumatic immune response culminates in the release of pro-inflammatory mediators, translating in the infiltration of neutrophils (PMNs) at injury sites. The extent of this inflammation is determined by multiple factors, such as PMN adhesion to the endothelium, transendothelial migration, endothelial barrier integrity as well as PMN swarming, mass infiltration and activation. This process is initiated by secondary lipid mediators, such as leukotriene B

Identifiants

pubmed: 36936923
doi: 10.3389/fimmu.2023.1093022
pmc: PMC10017463
doi:

Substances chimiques

Protein Kinases EC 2.7.-

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1093022

Informations de copyright

Copyright © 2023 Schönfelder, Seibold, Morawe, Sroka, Schneider, Cai, Golomejic, Schütte, Armacki, Huber-Lang, Kalbitz, Seufferlein and Eiseler.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Jonathan Schönfelder (J)

Department of Internal Medicine I, University Hospital Ulm, Ulm, Germany.

Tanja Seibold (T)

Department of Internal Medicine I, University Hospital Ulm, Ulm, Germany.

Mareen Morawe (M)

Department of Internal Medicine I, University Hospital Ulm, Ulm, Germany.

Robert Sroka (R)

Department of Internal Medicine I, University Hospital Ulm, Ulm, Germany.

Nora Schneider (N)

Department of Internal Medicine I, University Hospital Ulm, Ulm, Germany.

Jierui Cai (J)

Department of Internal Medicine I, University Hospital Ulm, Ulm, Germany.

Josip Golomejic (J)

Department of Internal Medicine I, University Hospital Ulm, Ulm, Germany.

Lena Schütte (L)

Department of Internal Medicine I, University Hospital Ulm, Ulm, Germany.

Milena Armacki (M)

Department of Internal Medicine I, University Hospital Ulm, Ulm, Germany.

Markus Huber-Lang (M)

Institute of Clinical and Experimental Trauma-Immunology, University Hospital Ulm, Ulm, Germany.

Miriam Kalbitz (M)

Department of Traumatology, Hand-, Plastic, and Reconstructive Surgery, University Hospital Ulm, Ulm, Germany.

Thomas Seufferlein (T)

Department of Internal Medicine I, University Hospital Ulm, Ulm, Germany.

Tim Eiseler (T)

Department of Internal Medicine I, University Hospital Ulm, Ulm, Germany.

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Classifications MeSH