Effect of combined therapies including nutrition and physical exercise in advanced cancer patients: A pooled analysis.
cachexia
cancer
dietary counseling
malnutrition
physical exercise
Journal
Frontiers in nutrition
ISSN: 2296-861X
Titre abrégé: Front Nutr
Pays: Switzerland
ID NLM: 101642264
Informations de publication
Date de publication:
2023
2023
Historique:
received:
06
10
2022
accepted:
06
02
2023
entrez:
20
3
2023
pubmed:
21
3
2023
medline:
21
3
2023
Statut:
epublish
Résumé
Although many cancer patients suffer from malnutrition or cancer cachexia, there is no standard of care so far due to limited intervention trials. Pooled data from two combined trials were analyzed regarding nutritional status and survival time. Data from two trials with advanced cancer patients were included. In both trials, patients in the intervention group received at least three times nutritional counseling and supervised training sessions. Patients in the control group continued being treated according to usual care. Nutritional status was measured using BMI, body composition and handgrip strength. Survival time was analyzed using the Cox proportional hazard model with the period between the beginning of the trial and death as underlying time scale. 68 men (61.8%) and 42 women (38.2%) were randomized either to the intervention ( The pooled analysis showed a significant improvement of handgrip strength in advanced cancer patients through the implementation of a combined therapy. Handgrip strength is of prognostic significance in hospitalized patients due to its association with mortality and morbidity. However, no improvements in further tests were detected. There is great need for further investigations examining the effect of nutritional and exercise therapy on survival time with focus on different cancer diagnoses.
Sections du résumé
Background and aims
UNASSIGNED
Although many cancer patients suffer from malnutrition or cancer cachexia, there is no standard of care so far due to limited intervention trials. Pooled data from two combined trials were analyzed regarding nutritional status and survival time.
Materials and methods
UNASSIGNED
Data from two trials with advanced cancer patients were included. In both trials, patients in the intervention group received at least three times nutritional counseling and supervised training sessions. Patients in the control group continued being treated according to usual care. Nutritional status was measured using BMI, body composition and handgrip strength. Survival time was analyzed using the Cox proportional hazard model with the period between the beginning of the trial and death as underlying time scale.
Results
UNASSIGNED
68 men (61.8%) and 42 women (38.2%) were randomized either to the intervention (
Conclusion
UNASSIGNED
The pooled analysis showed a significant improvement of handgrip strength in advanced cancer patients through the implementation of a combined therapy. Handgrip strength is of prognostic significance in hospitalized patients due to its association with mortality and morbidity. However, no improvements in further tests were detected. There is great need for further investigations examining the effect of nutritional and exercise therapy on survival time with focus on different cancer diagnoses.
Identifiants
pubmed: 36937336
doi: 10.3389/fnut.2023.1063279
pmc: PMC10014851
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1063279Informations de copyright
Copyright © 2023 Storck, Uster, Gafner, Ruehlin, Gaeumann, Gisi, Schmocker, Meffert, Imoberdorf, Pless and Ballmer.
Déclaration de conflit d'intérêts
PM was employed by company Corvus, Statistical Analysis Consulting, Altkalen, Germany. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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