Computational and experimental studies of salvianolic acid A targets 3C protease to inhibit enterovirus 71 infection.
EV71
HFMD
antiviral
inhibitor
salvianolic acid A
Journal
Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923
Informations de publication
Date de publication:
2023
2023
Historique:
received:
07
12
2022
accepted:
22
02
2023
entrez:
20
3
2023
pubmed:
21
3
2023
medline:
21
3
2023
Statut:
epublish
Résumé
Hand, foot, and mouth disease (HFMD) is a common childhood infectious disease caused by enterovirus (EV) infection. EV71 is one of the major pathogens causing hand, foot, and mouth disease and is more likely to cause exacerbation and death than other enteroviruses. Although a monovalent vaccine for EV71 has been developed, there are no clinically available anti-EV71 specific drugs. Here, we performed virtual screening and biological experiments based on the traditional Chinese medicine monomer library. We identified a traditional Chinese medicine monomer, Salvianolic acid A (SA), a polyphenolic compound isolated from
Identifiants
pubmed: 36937869
doi: 10.3389/fphar.2023.1118584
pii: 1118584
pmc: PMC10017496
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1118584Informations de copyright
Copyright © 2023 Shi, Xie, Ma, Xu, An, Ye and Wang.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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