The role of opioid receptors in modulating Alzheimer's Disease.
Alzheimer’s disease
amyloid-β
neurodegenerative disorders
opioid receptors
β-secretase-1
Journal
Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923
Informations de publication
Date de publication:
2023
2023
Historique:
received:
28
09
2022
accepted:
20
02
2023
entrez:
20
3
2023
pubmed:
21
3
2023
medline:
21
3
2023
Statut:
epublish
Résumé
Alzheimer's disease (AD) is a complex neurological disorder characterized by accumulation of amyloid plaques and neurofibrillary tangles. Long term investigation of AD pathogenesis suggests that β-site amyloid precursor protein [APP] cleaving enzyme 1 (BACE1) and γ-secretase enzymes promote the amyloidogenic pathway and produce toxic Aβ peptides that are predisposed to aggregate in the brain. Hence, the targeted inhibition of BACE1/γ-secretase expression and function is a promising approach for AD therapy. Several reports have suggested that the opioid family of G-protein coupled receptors modulate the etiology of AD progression. It has also been found that changes in the signaling pathways of opioid receptors increased the expression of BACE1 and γ-secretase, and is strongly correlated with abnormal production of Aβ and pathogenesis of AD. Thus, the opioid receptor family is a promising candidate for targeted drug development to treat AD. In this review, we outline the involvement and mechanisms of opioid receptor signaling modulation in Alzheimer's Disease progression.
Identifiants
pubmed: 36937877
doi: 10.3389/fphar.2023.1056402
pii: 1056402
pmc: PMC10014470
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1056402Informations de copyright
Copyright © 2023 Tanguturi and Streicher.
Déclaration de conflit d'intérêts
JS has an equity stake in Teleport Pharmaceuticals, LLC and Botanical Results, LLC. The remaining author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Behav Neural Biol. 1985 Nov;44(3):499-502
pubmed: 3002317
Brain Res. 1987 Mar 17;406(1-2):17-23
pubmed: 3032356
J Biol Chem. 2005 Nov 18;280(46):38478-88
pubmed: 16159882
J Neurosci. 2011 Nov 9;31(45):16227-40
pubmed: 22072674
Brain Res. 2001 Mar 2;893(1-2):121-34
pubmed: 11223000
JAMA. 1999 Mar 17;281(11):1000-5
pubmed: 10086434
ACS Med Chem Lett. 2017 Mar 14;8(4):449-454
pubmed: 28435535
ACS Chem Neurosci. 2012 Jul 18;3(7):505-9
pubmed: 22860219
Handb Exp Pharmacol. 2018;247:C1-C2
pubmed: 31309359
Br J Pain. 2012 Feb;6(1):11-6
pubmed: 26516461
ACS Chem Neurosci. 2023 Feb 1;14(3):506-515
pubmed: 36651179
Cell Mol Life Sci. 2021 Jan;78(2):415-426
pubmed: 32671427
JAMA. 1997 Oct 22-29;278(16):1349-56
pubmed: 9343467
Prog Neuropsychopharmacol Biol Psychiatry. 1986;10(3-5):599-610
pubmed: 3541054
J Neurosci. 2000 Nov 15;20(22):RC110
pubmed: 11069979
Nat Med. 2013 Jan;19(1):43-9
pubmed: 23202293
PLoS One. 2013 Sep 12;8(9):e74680
pubmed: 24069330
Anesthesiology. 2011 Dec;115(6):1363-81
pubmed: 22020140
Nat Rev Neurosci. 2011 Feb;12(2):73-87
pubmed: 21248787
Mol Med Rep. 2018 Nov;18(5):4297-4302
pubmed: 30152845
Tanpakushitsu Kakusan Koso. 2000 Apr;45(6 Suppl):985-90
pubmed: 10771662
Neurochem Res. 1996 Nov;21(11):1333-45
pubmed: 8947923
Ann Neurol. 2010 Jan;67(1):122-31
pubmed: 20186853
Alzheimers Dement. 2013 Mar;9(2):208-45
pubmed: 23507120
ACS Med Chem Lett. 2022 Oct 17;13(11):1707-1714
pubmed: 36385929
Front Cell Neurosci. 2020 Apr 30;14:88
pubmed: 32425755
Drug Discov Today. 2018 Jul;23(7):1385-1395
pubmed: 29501910
Nature. 2016 Nov 09;539(7628):187-196
pubmed: 27830780
Brain. 2007 Apr;130(Pt 4):1017-28
pubmed: 17347252
Proc Natl Acad Sci U S A. 1995 Jul 18;92(15):7006-10
pubmed: 7624359
Brain Res. 2021 Apr 15;1757:147297
pubmed: 33516811
Curr Opin Pharmacol. 2002 Feb;2(1):76-81
pubmed: 11786312
Hum Mol Genet. 2007 Jan 1;16(1):15-23
pubmed: 17135279
Int J Mol Sci. 2019 Sep 03;20(17):
pubmed: 31484312
J Pediatr Genet. 2015 Apr 1;4(2):56-70
pubmed: 26998394
Hum Mol Genet. 2014 Aug 1;23(15):4024-34
pubmed: 24626633
Science. 1993 Aug 13;261(5123):921-3
pubmed: 8346443
Hum Mol Genet. 2005 Aug 15;14(16):2399-404
pubmed: 16000317
PLoS One. 2015 Nov 04;10(11):e0142046
pubmed: 26535894
Nature. 2012 May 16;485(7398):400-4
pubmed: 22596164
Front Cell Dev Biol. 2022 Apr 04;10:852738
pubmed: 35445022
Nat Rev Neurol. 2013 Feb;9(2):106-18
pubmed: 23296339
CNS Neurosci Ther. 2015 Jan;21(1):8-14
pubmed: 25146548
Cell Res. 2010 Feb;20(2):138-53
pubmed: 20066010
J Neurosci. 2008 May 7;28(19):5007-17
pubmed: 18463254
Brain. 2010 Dec;133(Pt 12):3685-98
pubmed: 21126996
J Accid Emerg Med. 2000 Jul;17(4):261-4
pubmed: 10921813
Am J Physiol Heart Circ Physiol. 2007 Sep;293(3):H1604-8
pubmed: 17545478
Neuromolecular Med. 2012 Jun;14(2):91-111
pubmed: 22527793
J Pharmacol Exp Ther. 2019 Nov;371(2):409-415
pubmed: 30940694
Neurology. 2017 Sep 5;89(10):1028-1034
pubmed: 28794245
Lancet. 2011 Mar 19;377(9770):1019-31
pubmed: 21371747
Neuropharmacology. 2004;47 Suppl 1:312-23
pubmed: 15464147
AAPS J. 2006 Mar 10;8(1):E118-25
pubmed: 16584118
Ann Neurol. 2008 Oct;64(4):446-54
pubmed: 18991351
Curr Opin Pharmacol. 2002 Feb;2(1):69-75
pubmed: 11786311
Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4903-8
pubmed: 12679517
Acta Physiol Scand. 1988 Mar;132(3):281-8
pubmed: 2852436
Prog Neurobiol. 2002 Apr;66(5):285-306
pubmed: 12015197
Am J Ther. 2006 Nov-Dec;13(6):534-42
pubmed: 17122535
Br J Pharmacol. 2005 Feb;144(3):400-4
pubmed: 15655510
Brain Res Bull. 2009 Oct 28;80(4-5):248-50
pubmed: 19477245
Trends Pharmacol Sci. 1999 Jan;20(1):19-26
pubmed: 10101958
Neurosci Lett. 2015 Oct 8;606:24-9
pubmed: 26300544
Inflammopharmacology. 2018 Aug;26(4):925-938
pubmed: 29249049
Alzheimers Dement. 2018 May;14(5):692-698
pubmed: 29524426
Sci Adv. 2020 Aug 05;6(32):eabc0413
pubmed: 32821843
Neurobiol Aging. 2014 Apr;35(4):731-45
pubmed: 24238656
J Alzheimers Dis. 2015;48(2):507-16
pubmed: 26402014
Cell Res. 2013 Mar;23(3):351-65
pubmed: 23208420
Proc Natl Acad Sci U S A. 1993 Mar 1;90(5):1977-81
pubmed: 8446617
Lancet. 2016 Jul 30;388(10043):505-17
pubmed: 26921134
Br J Pharmacol. 2019 Sep;176(18):3636-3648
pubmed: 30657599
Annu Rev Physiol. 2007;69:483-510
pubmed: 17305471
PLoS One. 2014 Nov 03;9(11):e110773
pubmed: 25364831
J Neurosci. 2003 Jul 2;23(13):5674-83
pubmed: 12843270
J Alzheimers Dis. 2018;65(1):283-292
pubmed: 30040717
J Biol Chem. 2000 Aug 25;275(34):26128-35
pubmed: 10842167
PLoS One. 2013 Sep 10;8(9):e73129
pubmed: 24039871
Neurobiol Dis. 2007 Jul;27(1):1-10
pubmed: 17555970
Cell Mol Life Sci. 2012 Mar;69(6):857-96
pubmed: 22002579
Biol Psychiatry. 2021 Apr 15;89(8):745-756
pubmed: 32223911
Molecules. 2021 Nov 05;26(21):
pubmed: 34771099
Nat Med. 2006 Dec;12(12):1390-6
pubmed: 17115048
Proc Natl Acad Sci U S A. 2022 Jun 7;119(23):e2115714119
pubmed: 35639699
Arch Gen Psychiatry. 2006 Feb;63(2):210-8
pubmed: 16461865
Nat Neurosci. 2013 Nov;16(11):1537-43
pubmed: 24165680