Delivery route considerations for designing antigen-specific biomaterial strategies to combat autoimmunity.
Journal
Advanced nanobiomed research
ISSN: 2699-9307
Titre abrégé: Adv Nanobiomed Res
Pays: Germany
ID NLM: 101773117
Informations de publication
Date de publication:
Mar 2023
Mar 2023
Historique:
pmc-release:
01
03
2024
entrez:
20
3
2023
pubmed:
21
3
2023
medline:
21
3
2023
Statut:
ppublish
Résumé
Disease modifying drugs and biologics used to treat autoimmune diseases, although promising, are non-curative. As the field moves towards development of new approaches to treat autoimmune disease, antigen-specific therapies immunotherapies (ASITs) have emerged. Despite clinical approval of ASITs for allergies, clinical trials using soluble ASITs for autoimmunity have been largely unsuccessful. A major effort to address this shortcoming is the use of biomaterials to harness the features unique to specific delivery routes. This review focuses on biomaterials being developed for delivery route-specific strategies to induce antigen-specific responses in autoimmune diseases such as multiple sclerosis, type 1 diabetes, rheumatoid arthritis, and celiac disease. We first discuss the delivery strategies used in ongoing and completed clinical trials in autoimmune ASITs. Next, we highlight pre-clinical biomaterial approaches from the most recent 3 years in the context of these same delivery route considerations. Lastly, we provide discussion on the gaps remaining in biomaterials development and comment on the need to consider delivery routes in the process of designing biomaterials for ASITs.
Identifiants
pubmed: 36938103
doi: 10.1002/anbr.202200135
pmc: PMC10019031
mid: NIHMS1873059
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : BLRD VA
ID : I01 BX003690
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI144667
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI169686
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01 EB027143
Pays : United States
Déclaration de conflit d'intérêts
Conflicts of interest CMJ is an employee of the VA Maryland Health Care System. The views reported here do not reflect the views of the VA or United States Government. CMJ has an equity position with Vaccitech plc. Beyond these declarations, there are no other conflicts of interests to report. The review was conducted in the absence of any commercial or financial relationships.
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