Relationship Between Vitamin D Deficiency and Non-alcoholic Fatty Liver Disease: A Cross-Sectional Study From a Tertiary Care Center in Northern India.
body mass index
insulin resistance
non-alcoholic fatty liver disease
non-alcoholic steatohepatitis
vitamin d
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
Feb 2023
Feb 2023
Historique:
accepted:
13
02
2023
entrez:
20
3
2023
pubmed:
21
3
2023
medline:
21
3
2023
Statut:
epublish
Résumé
Background Vitamin D levels are strongly associated with myocardial infarction, coronary artery disease, heart dysfunction, and even mortality. Non-alcoholic fatty liver disease (NAFLD) is a prevalent hepatic illness whose incidence has grown dramatically over the past several decades. Methodology This observational, cross-sectional study was conducted over 1.5 years (January 2019 to June 2020) at the Department of General Medicine of a tertiary care hospital in northern India on 100 adult patients with NAFLD admitted to the emergency ward, intensive care unit, and medical ward. Results In our study, of the 100 patients, 45.0%, 16.0%, and 39.0% of patients exhibited vitamin D deficiency, insufficiency, and sufficiency, respectively. Vitamin D deficiency was the highest among those aged 41-50 (54.2%) and lowest among those aged 30-40 (29.0%). We observed that vitamin D deficiency was less prevalent in people with a normal body mass index (39.1%) than in those who were overweight (91.7%). There was a significant (p < 0.05) association between the severity of vitamin D deficiency and the presence of hepatomegaly, splenomegaly, and ascites. Overall, the incidence of fatty liver was 49% among patients. There was a significant (p = 0.0001) correlation between fatty liver and serum vitamin D levels. The association between the proportion of patients with fatty liver and the degree of vitamin D deficiency was found to be significant (p = 0.04). The relationship between the distribution of patients according to insulin resistance and the degree of vitamin D deficiency was also statistically significant (p < 0.001). Conclusions Vitamin D deficiency is associated with an increased risk of NAFLD, as well as with the severity of NAFLD.
Identifiants
pubmed: 36938188
doi: 10.7759/cureus.34921
pmc: PMC10015758
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e34921Informations de copyright
Copyright © 2023, Kumar et al.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Medicine (Baltimore). 2016 Jul;95(29):e4293
pubmed: 27442673
Clin Liver Dis. 2007 Feb;11(1):37-54, viii
pubmed: 17544971
BMC Med. 2011 Jul 12;9:85
pubmed: 21749681
World J Gastrointest Pathophysiol. 2017 May 15;8(2):11-26
pubmed: 28573064
Nutrients. 2012 Jan;4(1):52-67
pubmed: 22347618
World J Gastroenterol. 2017 May 21;23(19):3407-3417
pubmed: 28596677
Eur Heart J. 2012 May;33(10):1190-200
pubmed: 22408036
J Clin Endocrinol Metab. 2011 May;96(5):1560-7
pubmed: 21367931
J Korean Med Sci. 2017 Jan;32(1):95-101
pubmed: 27914137
J Hepatol. 2015 Feb;62(2):405-11
pubmed: 25195551
Lancet Gastroenterol Hepatol. 2022 Sep;7(9):851-861
pubmed: 35798021
Dis Markers. 2015;2015:580474
pubmed: 26576069
Hepatobiliary Surg Nutr. 2019 Apr;8(2):164-166
pubmed: 31098369
Clin Nutr. 2016 Dec;35(6):1259-1268
pubmed: 27020528
Semin Liver Dis. 2012 Feb;32(1):22-9
pubmed: 22418885
PLoS One. 2016 Jun 10;11(6):e0157515
pubmed: 27284686
World J Gastroenterol. 2013 May 28;19(20):3134-42
pubmed: 23716995
Diabetes Metab Res Rev. 2008 Sep;24(6):459-64
pubmed: 18551686
Eur J Nutr. 2010 Oct;49(7):401-7
pubmed: 20204652
Clin Mol Hepatol. 2016 Mar;22(1):146-51
pubmed: 27044765
Gastroenterol Hepatol (N Y). 2006 Apr;2(4):282-291
pubmed: 28286458
PLoS Med. 2013;10(2):e1001383
pubmed: 23393431
J Clin Endocrinol Metab. 2010 Sep;95(9):4251-7
pubmed: 20534751
Am J Cardiol. 2010 Oct 1;106(7):963-8
pubmed: 20854958
Am J Gastroenterol. 2007 Dec;102(12):2708-15
pubmed: 17894848
Fed Pract. 2019 Feb;36(2):64-71
pubmed: 30867626
Int J Prev Med. 2019 Jan 15;10:14
pubmed: 30774848
Endocr Connect. 2022 Jan 11;11(1):
pubmed: 34860171
Br Med J (Clin Res Ed). 1986 Jan 4;292(6512):13-5
pubmed: 3080046