Biomarker Response to Mindfulness Intervention in Veterans Diagnosed with Post-traumatic Stress Disorder.
Cortisol
Inflammatory markers
Meditation
Mindfulness
Mindfulness-based stress reduction
Post-traumatic stress disorder
Veterans
Journal
Mindfulness
ISSN: 1868-8527
Titre abrégé: Mindfulness (N Y)
Pays: United States
ID NLM: 101518348
Informations de publication
Date de publication:
Oct 2022
Oct 2022
Historique:
entrez:
20
3
2023
pubmed:
21
3
2023
medline:
21
3
2023
Statut:
ppublish
Résumé
This study evaluates the effects of treatment with mindfulness-based stress reduction (MBSR) compared to the active control, present-centered group therapy (PCGT), on morning plasma cortisol, interleukin-6 (IL-6), and C-reactive protein (CRP) in veterans diagnosed with post-traumatic stress disorder (PTSD). In a post hoc exploratory analysis, we pooled biomarkers and clinical outcomes of mindfulness, PTSD, and depression from two randomized controlled trials comparing MBSR ( Cortisol levels were inversely related to self-reported PTSD symptoms at baseline ( Increased mindfulness is associated with a recalibration of cortisol levels which may be indicative of therapeutic response, especially in patients with lower baseline cortisol. Furthermore, mindfulness-based practices improve symptoms of PTSD and depression in a significant correlation with self-reported levels of mindfulness. NCT01532999 and NCT01548742.
Identifiants
pubmed: 36938380
doi: 10.1007/s12671-022-01969-6
pmc: PMC10022677
mid: NIHMS1881581
doi:
Banques de données
ClinicalTrials.gov
['NCT01548742', 'NCT01532999']
Types de publication
Journal Article
Langues
eng
Pagination
2448-2460Subventions
Organisme : RRD VA
ID : I01 RX003418
Pays : United States
Organisme : CSRD VA
ID : I01 CX000687
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH120262
Pays : United States
Organisme : NCCIH NIH HHS
ID : R33 AT010802
Pays : United States
Organisme : NIMH NIH HHS
ID : K24 MH076955
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL101398
Pays : United States
Organisme : NIDA NIH HHS
ID : UG3 DA048502
Pays : United States
Déclaration de conflit d'intérêts
Conflict of Interest The authors declare no competing interests.
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