Emerging targets for therapy in ALD: Lessons from NASH.
Journal
Hepatology (Baltimore, Md.)
ISSN: 1527-3350
Titre abrégé: Hepatology
Pays: United States
ID NLM: 8302946
Informations de publication
Date de publication:
21 Mar 2023
21 Mar 2023
Historique:
received:
26
12
2022
accepted:
09
03
2023
pmc-release:
21
09
2024
pubmed:
21
3
2023
medline:
21
3
2023
entrez:
20
3
2023
Statut:
aheadofprint
Résumé
Alcohol-associated liver disease due to harmful alcohol use and NAFLD associated with metabolic syndrome are the 2 most common liver diseases worldwide. Control of respective risk factors is the cornerstone in the long-term management of these diseases. Furthermore, there are no effective therapies. Both diseases are characterized by metabolic derangements; thus, the focus of this review was to broaden our understanding of metabolic targets investigated in NAFLD, and how these can be applied to alcohol-associated liver disease. Conserved pathogenic pathways such as dysregulated lipid metabolism, cell death pathways including apoptosis and activation of innate immune cells, and stellate cells mediate both alcohol and NAFLDs, resulting in histological abnormalities of steatosis, inflammation, fibrosis, and cirrhosis. However, pathways such as gut microbiome changes, glucose metabolism and insulin resistance, inflammatory signaling, and microRNA abnormalities are distinct in these 2 diseases. In this review article, we describe conserved and distinct pathogenic pathways highlighting therapeutic targets that may be of potential in both diseases and those that are unique to each disease.
Identifiants
pubmed: 36938877
doi: 10.1097/HEP.0000000000000381
pii: 01515467-990000000-00345
pmc: PMC10511666
mid: NIHMS1909403
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK111378
Pays : United States
Organisme : NIAAA NIH HHS
ID : U01 AA021788
Pays : United States
Informations de copyright
Copyright © 2023 American Association for the Study of Liver Diseases.
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