Large-Scale Proteomics Data Reveal Integrated Prognosis-Related Protein Signatures and Role of SMAD4 and RAD50 in Prognosis and Immune Infiltrations of Prostate Cancer Microenvironment.
Double-strand break repair protein RAD50
Prognosis
Prostate cancer
Proteomics
SMAD family member 4
Journal
Phenomics (Cham, Switzerland)
ISSN: 2730-5848
Titre abrégé: Phenomics
Pays: Switzerland
ID NLM: 9918351171706676
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
received:
01
10
2021
revised:
28
07
2022
accepted:
04
08
2022
entrez:
20
3
2023
pubmed:
21
3
2023
medline:
21
3
2023
Statut:
epublish
Résumé
As prostate cancer (PCa) is one of the most commonly diagnosed cancer worldwide, identifying potential prognostic biomarkers is crucial. In this study, the survival information, gene expression, and protein expression data of 344 PCa cases were collected from the Cancer Proteome Atlas (TCPA) and the Cancer Genome Atlas (TCGA) to investigate the potential prognostic biomarkers. The integrated prognosis-related proteins (IPRPs) model was constructed based on the risk score of each patients using machine-learning algorithm. IPRPs model suggested that Elevated The online version contains supplementary material available at 10.1007/s43657-022-00070-1.
Identifiants
pubmed: 36939777
doi: 10.1007/s43657-022-00070-1
pii: 70
pmc: PMC9712904
doi:
Types de publication
Journal Article
Langues
eng
Pagination
404-418Informations de copyright
© International Human Phenome Institutes (Shanghai) 2022, Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
Déclaration de conflit d'intérêts
Conflict of interestThe authors declare that they have no conflict of interest.
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