A Meta-Analysis of the Genome-Wide Association Studies on Two Genetically Correlated Phenotypes Suggests Four New Risk Loci for Headaches.
Correlated phenotypes
Genome-wide association study
Headache
Meta-analysis
Migraine
Unified Score-based Association Test
Journal
Phenomics (Cham, Switzerland)
ISSN: 2730-5848
Titre abrégé: Phenomics
Pays: Switzerland
ID NLM: 9918351171706676
Informations de publication
Date de publication:
Feb 2023
Feb 2023
Historique:
received:
14
05
2022
revised:
16
09
2022
accepted:
21
09
2022
entrez:
20
3
2023
pubmed:
21
3
2023
medline:
21
3
2023
Statut:
epublish
Résumé
Headache is one of the commonest complaints that doctors need to address in clinical settings. The genetic mechanisms of different types of headache are not well understood while it has been suggested that self-reported headache and self-reported migraine were genetically correlated. In this study, we performed a meta-analysis of genome-wide association studies (GWAS) on the self-reported headache phenotype from the UK Biobank and the self-reported migraine phenotype from the 23andMe using the Unified Score-based Association Test (metaUSAT) software for genetically correlated phenotypes ( The online version contains supplementary material available at 10.1007/s43657-022-00078-7.
Identifiants
pubmed: 36939796
doi: 10.1007/s43657-022-00078-7
pii: 78
pmc: PMC9883337
doi:
Types de publication
Journal Article
Langues
eng
Pagination
64-76Subventions
Organisme : Medical Research Council
ID : MC_PC_17228
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_QA137853
Pays : United Kingdom
Informations de copyright
© The Author(s) 2022.
Déclaration de conflit d'intérêts
Conflict of interestThe employees of 23andMe/23andMe Research Team hold stock in the company. The other authors declare that they have no conflict of interest.
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