Camera-based Prospective Motion Correction in Paediatric Epilepsy Patients Enables EEG-fMRI Localization Even in High-motion States.
Drug-resistant epilepsy
EEG-fMRI
Pediatric epilepsy
Prospective motion correction
Journal
Brain topography
ISSN: 1573-6792
Titre abrégé: Brain Topogr
Pays: United States
ID NLM: 8903034
Informations de publication
Date de publication:
05 2023
05 2023
Historique:
received:
01
09
2022
accepted:
14
02
2023
medline:
8
5
2023
pubmed:
21
3
2023
entrez:
20
3
2023
Statut:
ppublish
Résumé
EEG-fMRI is a useful additional test to localize the epileptogenic zone (EZ) particularly in MRI negative cases. However subject motion presents a particular challenge owing to its large effects on both MRI and EEG signal. Traditionally it is assumed that prospective motion correction (PMC) of fMRI precludes EEG artifact correction. Children undergoing presurgical assessment at Great Ormond Street Hospital were included into the study. PMC of fMRI was done using a commercial system with a Moiré Phase Tracking marker and MR-compatible camera. For retrospective EEG correction both a standard and a motion educated EEG artefact correction (REEGMAS) were compared to each other. Ten children underwent simultaneous EEG-fMRI. Overall head movement was high (mean RMS velocity < 1.5 mm/s) and showed high inter- and intra-individual variability. Comparing motion measured by the PMC camera and the (uncorrected residual) motion detected by realignment of fMRI images, there was a five-fold reduction in motion from its prospective correction. Retrospective EEG correction using both standard approaches and REEGMAS allowed the visualization and identification of physiological noise and epileptiform discharges. Seven of 10 children had significant maps, which were concordant with the clinical EZ hypothesis in 6 of these 7. To our knowledge this is the first application of camera-based PMC for MRI in a pediatric clinical setting. Despite large amount of movement PMC in combination with retrospective EEG correction recovered data and obtained clinically meaningful results during high levels of subject motion. Practical limitations may currently limit the widespread use of this technology.
Sections du résumé
BACKGROUND
EEG-fMRI is a useful additional test to localize the epileptogenic zone (EZ) particularly in MRI negative cases. However subject motion presents a particular challenge owing to its large effects on both MRI and EEG signal. Traditionally it is assumed that prospective motion correction (PMC) of fMRI precludes EEG artifact correction.
METHODS
Children undergoing presurgical assessment at Great Ormond Street Hospital were included into the study. PMC of fMRI was done using a commercial system with a Moiré Phase Tracking marker and MR-compatible camera. For retrospective EEG correction both a standard and a motion educated EEG artefact correction (REEGMAS) were compared to each other.
RESULTS
Ten children underwent simultaneous EEG-fMRI. Overall head movement was high (mean RMS velocity < 1.5 mm/s) and showed high inter- and intra-individual variability. Comparing motion measured by the PMC camera and the (uncorrected residual) motion detected by realignment of fMRI images, there was a five-fold reduction in motion from its prospective correction. Retrospective EEG correction using both standard approaches and REEGMAS allowed the visualization and identification of physiological noise and epileptiform discharges. Seven of 10 children had significant maps, which were concordant with the clinical EZ hypothesis in 6 of these 7.
CONCLUSION
To our knowledge this is the first application of camera-based PMC for MRI in a pediatric clinical setting. Despite large amount of movement PMC in combination with retrospective EEG correction recovered data and obtained clinically meaningful results during high levels of subject motion. Practical limitations may currently limit the widespread use of this technology.
Identifiants
pubmed: 36939987
doi: 10.1007/s10548-023-00945-0
pii: 10.1007/s10548-023-00945-0
pmc: PMC10164016
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
319-337Subventions
Organisme : Wellcome Trust
ID : WT 203148/Z/16/Z
Pays : United Kingdom
Informations de copyright
© 2023. The Author(s).
Références
Brain Topogr. 2021 Nov;34(6):745-761
pubmed: 34554373
Neuroimage. 2014 Nov 1;101:21-34
pubmed: 24969568
Epilepsia. 2013 Jun;54(6):971-82
pubmed: 23647021
Magn Reson Imaging. 2007 Jul;25(6):894-901
pubmed: 17490845
Neuroimage Clin. 2016 Mar 23;11:486-493
pubmed: 27114897
Neuroimage. 2020 May 15;212:116594
pubmed: 32044436
Neuroimage. 2001 Sep;14(3):780-7
pubmed: 11506550
Magn Reson Imaging. 2003 Dec;21(10):1159-66
pubmed: 14725923
Top Magn Reson Imaging. 2002 Feb;13(1):61-70
pubmed: 11847501
Brain. 2011 Oct;134(Pt 10):2867-86
pubmed: 21752790
Neurology. 2021 Aug 16;:
pubmed: 34400584
Eur J Paediatr Neurol. 2018 Nov;22(6):1054-1065
pubmed: 30017619
Neuroimage. 2010 Oct 15;53(1):139-45
pubmed: 20542120
MAGMA. 2010 Sep;23(4):263-73
pubmed: 20694501
AJNR Am J Neuroradiol. 2021 Apr;42(4):774-781
pubmed: 33602745
Neuroimage. 2016 Sep;138:13-27
pubmed: 27157789
Epilepsy Behav. 2010 Jul;18(3):313-6
pubmed: 20605747
Front Neurol. 2014 Sep 11;5:175
pubmed: 25309503
Seizure. 2011 Dec;20(10):809-12
pubmed: 21920780
Neuroimage. 2016 Jan 1;124(Pt A):1009-1020
pubmed: 26416652
Radiology. 2018 Nov;289(2):509-516
pubmed: 30063192
Neuroimage. 2006 Jul 1;31(3):1038-50
pubmed: 16600642
Seizure. 2018 Oct;61:30-37
pubmed: 30059825
PLoS One. 2016 Feb 12;11(2):e0149048
pubmed: 26872220
Neuroimage. 2014 Jan 1;84:320-41
pubmed: 23994314
Magn Reson Med. 2013 Mar 1;69(3):621-36
pubmed: 22570274
Neuroimage. 2015 Jan 15;105:536-51
pubmed: 25462692
Ann Neurol. 2017 Aug;82(2):278-287
pubmed: 28749544
Neuroimage. 2000 Aug;12(2):230-9
pubmed: 10913328
Neuroimage. 2015 Jun;113:1-12
pubmed: 25783205
Front Neurol. 2014 Jul 04;5:93
pubmed: 25071695
PLoS One. 2013 Nov 06;8(11):e77089
pubmed: 24223118
Neuroimage. 2017 Jul 1;154:33-42
pubmed: 27845256
Brain. 2004 May;127(Pt 5):1127-44
pubmed: 15033899
Brain. 2012 Dec;135(Pt 12):3645-63
pubmed: 23250884
Nat Rev Neurol. 2019 Oct;15(10):594-606
pubmed: 31341275
Magn Reson Med. 1994 Mar;31(3):283-91
pubmed: 8057799
Neuroimage. 2014 Jan 1;84:124-32
pubmed: 23954484
Front Neurosci. 2015 Mar 25;9:97
pubmed: 25859178
Neuroimage. 2009 Jul 1;46(3):834-43
pubmed: 19408351
Brain Res. 2006 May 9;1088(1):148-66
pubmed: 16678803
Epilepsia. 2020 Jan;61(1):49-60
pubmed: 31792958
Neuroimage. 2012 Mar;60(1):623-32
pubmed: 22233733
J Magn Reson Imaging. 2015 Oct;42(4):887-901
pubmed: 25630632
Magn Reson Med. 1996 Mar;35(3):346-55
pubmed: 8699946