Granular cell tumors of the urethra.

Humans Granular Cell Tumor / drug therapy Urethral Neoplasms / therapy Vascular Endothelial Growth Factor A Sarcoma / drug therapy Soft Tissue Neoplasms / drug therapy Angiogenesis Inhibitors / therapeutic use
Chemotherapy Granular cell tumor Molecular biology Pazopanib Surgical excision Tyrosine kinase inhibitor Urethra

Journal

Cancer treatment and research communications
ISSN: 2468-2942
Titre abrégé: Cancer Treat Res Commun
Pays: England
ID NLM: 101694651

Informations de publication

Date de publication:
2023
Historique:
received: 28 05 2022
revised: 06 03 2023
accepted: 09 03 2023
medline: 15 5 2023
pubmed: 21 3 2023
entrez: 20 3 2023
Statut: ppublish

Résumé

Granular cell tumors (GCTs) are a rare type of mesenchymal tumors that are histologically derived by Schwann cells and rise within soft tissues such as skin and mucosal surfaces. Differentiation between benign and malignant GCTs is often difficult and relies on their biological behavior and metastatic potential. While there are no standard guidelines for management, upfront surgical resection, whenever feasible, is key as a definitive measure. Systemic therapy is often limited by poor chemosensitivity of these tumors; however, accumulating knowledge of their underlying genomic landscape has opened some opportunities for targeted approaches, for example, the vascular endothelial growth factor tyrosine kinase inhibitor pazopanib, which is already in clinical use for the treatment of many types of advanced soft tissue sarcomas.

Identifiants

DOI: 10.1016/j.ctarc.2023.100695 PMID: 36940531
pubmed: 36940531
pii: S2468-2942(23)00016-3
doi: 10.1016/j.ctarc.2023.100695
pii:
doi:

Substances chimiques

Vascular Endothelial Growth Factor A 0
Angiogenesis Inhibitors 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

100695

Informations de copyright

Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare no competing interests.

Auteurs

Konstantinos Evmorfopoulos (K)

Department of Urology, Faculty of Medicine, School of Health Sciences, University of Thessaly, University Hospital of Larissa, 41100 Larissa, Greece.

Vassilios Tzortzis (V)

Department of Urology, Faculty of Medicine, School of Health Sciences, University of Thessaly, University Hospital of Larissa, 41100 Larissa, Greece.

Panagiotis J Vlachostergios (PJ)

Department of Urology, Faculty of Medicine, School of Health Sciences, University of Thessaly, University Hospital of Larissa, 41100 Larissa, Greece; Department of Medicine, Division of Hematology and Medical Oncology, Weill Cornell Medicine, New York, NY 10065, USA. Electronic address: pjv9003@med.cornell.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Granular cell tumors of the urethra.
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu conjonctif et des tissus mous › Tumeurs du tissu musculaire › Tumeur à cellules granuleuses › Granular cell tumors of the urethra.
questionsmedicales.fr › Maladies urogénitales › Maladies urologiques › Tumeurs urologiques › Tumeurs de l'urètre › Granular cell tumors of the urethra.
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Protéines angiogéniques › Facteurs de croissance endothéliale vasculaire › Facteur de croissance endothéliale vasculaire de type A › Granular cell tumors of the urethra.
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu conjonctif et des tissus mous › Sarcomes › Granular cell tumors of the urethra.
questionsmedicales.fr › Tumeurs › Tumeurs par siège › Tumeurs des tissus mous › Granular cell tumors of the urethra.
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Inhibiteurs de l'angiogenèse › Granular cell tumors of the urethra.