Trabectedin modulates macrophage polarization in the tumor-microenvironment. Role of K
Cancer
K(V)1.3
K(V)1.5
Macrophages
TAMs
Trabectedin
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
ISSN: 1950-6007
Titre abrégé: Biomed Pharmacother
Pays: France
ID NLM: 8213295
Informations de publication
Date de publication:
May 2023
May 2023
Historique:
received:
05
12
2022
revised:
03
03
2023
accepted:
14
03
2023
medline:
3
4
2023
pubmed:
21
3
2023
entrez:
20
3
2023
Statut:
ppublish
Résumé
Immune cells have an important role in the tumor-microenvironment. Macrophages may tune the immune response toward inflammatory or tolerance pathways. Tumor-associated macrophages (TAM) have a string of immunosuppressive functions and they are considered a therapeutic target in cancer. This study aimed to analyze the effects of trabectedin, an antitumor agent, on the tumor-microenvironment through the characterization of the electrophysiological and molecular phenotype of macrophages. Experiments were performed using the whole-cell configuration of the patch-clamp technique in resident peritoneal mouse macrophages. Trabectedin does not directly interact with K
Identifiants
pubmed: 36940615
pii: S0753-3322(23)00336-0
doi: 10.1016/j.biopha.2023.114548
pii:
doi:
Substances chimiques
Trabectedin
ID0YZQ2TCP
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
114548Informations de copyright
Copyright © 2023 The Authors. Published by Elsevier Masson SAS.. All rights reserved.
Déclaration de conflit d'intérêts
Conflict of interest statement P.M.A. is an employee of PharmaMar. The authors declare to have received a grant from PharmaMar S.A. to support in part the costs of the research. Trabectedin was provided by PharmaMar S.A. This funder had no role in the design of the study; analyses and interpretation of data; in the writing of the manuscript; or in the decision to publish the results.