Evolutionary conservation of the fidelity of transcription.


Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
20 03 2023
Historique:
received: 15 12 2021
accepted: 03 02 2023
entrez: 21 3 2023
pubmed: 22 3 2023
medline: 23 3 2023
Statut: epublish

Résumé

Accurate transcription is required for the faithful expression of genetic information. However, relatively little is known about the molecular mechanisms that control the fidelity of transcription, or the conservation of these mechanisms across the tree of life. To address these issues, we measured the error rate of transcription in five organisms of increasing complexity and found that the error rate of RNA polymerase II ranges from 2.9 × 10

Identifiants

pubmed: 36941254
doi: 10.1038/s41467-023-36525-w
pii: 10.1038/s41467-023-36525-w
pmc: PMC10027832
doi:

Substances chimiques

RNA Polymerase II EC 2.7.7.-

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

1547

Subventions

Organisme : NIA NIH HHS
ID : R01 AG054641
Pays : United States

Informations de copyright

© 2023. The Author(s).

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Auteurs

Claire Chung (C)

School of Gerontology, University of Southern California, Los Angeles, CA, USA.

Bert M Verheijen (BM)

School of Gerontology, University of Southern California, Los Angeles, CA, USA.

Zoe Navapanich (Z)

School of Gerontology, University of Southern California, Los Angeles, CA, USA.

Eric G McGann (EG)

School of Gerontology, University of Southern California, Los Angeles, CA, USA.

Sarah Shemtov (S)

School of Gerontology, University of Southern California, Los Angeles, CA, USA.

Guan-Ju Lai (GJ)

School of Gerontology, University of Southern California, Los Angeles, CA, USA.

Payal Arora (P)

Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA, USA.

Atif Towheed (A)

Children's hospital of Philadelphia, Center for Mitochondrial and Epigenomic Medicine, Philadelphia, PA, USA.

Suraiya Haroon (S)

Children's hospital of Philadelphia, Center for Mitochondrial and Epigenomic Medicine, Philadelphia, PA, USA.

Agnes Holczbauer (A)

Children's hospital of Philadelphia, Center for Mitochondrial and Epigenomic Medicine, Philadelphia, PA, USA.

Sharon Chang (S)

Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Zarko Manojlovic (Z)

Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Stephen Simpson (S)

College of Life Sciences and Agriculture, University of New Hampshire, Durham, NH, USA.

Kelley W Thomas (KW)

College of Life Sciences and Agriculture, University of New Hampshire, Durham, NH, USA.

Craig Kaplan (C)

Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA, USA.

Peter van Hasselt (P)

Department of Metabolic Disease, University of Utrecht, Utrecht, the Netherlands.

Marc Timmers (M)

Department of Urology, Medical Center - University of Freiburg, Freiburg, Germany.
German Cancer Consortium (DKTK) Partner Site Freiburg, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Dorothy Erie (D)

Department of Chemistry, University of North Carolina, Chapel Hill, NC, USA.

Lin Chen (L)

Department of Molecular and Cellular Biology, University of Southern California, Los Angeles, CA, USA.

Jean-Franćois Gout (JF)

Department of Biological Sciences, Mississippi State University, Mississippi State, MS, USA.

Marc Vermulst (M)

School of Gerontology, University of Southern California, Los Angeles, CA, USA. vermulst@usc.edu.

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Classifications MeSH