Management of splanchnic vein thrombosis.
BCS, Budd-Chiari syndrome
CALR, calreticulin
Cavernoma
DOACs, direct-acting oral anticoagulants
Direct oral anticoagulants
EHPVO, extrahepatic portal vein obstruction
GFR, glomerular filtration rate
JAK2, Janus kinase 2
LMWH, low-molecular-weight heparin
MPN, myeloproliferative neoplasm
MTHFR, methylene-tetrahydrofolate reductase
PNH, paroxysmal nocturnal hemoglobinuria
PVT, portal vein thrombosis
Portal biliopathy
Portal vein recanalisation
SVT, splanchnic vein thrombosis
TIPS, transjugular intrahepatic portosystemic shunt
VKAs, vitamin K antagonists
Vascular liver diseases
Journal
JHEP reports : innovation in hepatology
ISSN: 2589-5559
Titre abrégé: JHEP Rep
Pays: Netherlands
ID NLM: 101761237
Informations de publication
Date de publication:
Apr 2023
Apr 2023
Historique:
received:
15
06
2022
revised:
11
12
2022
accepted:
23
12
2022
entrez:
21
3
2023
pubmed:
22
3
2023
medline:
22
3
2023
Statut:
epublish
Résumé
The expression splanchnic vein thrombosis encompasses Budd-Chiari syndrome and portal vein thrombosis. These disorders have common characteristics: they are both rare diseases which can cause portal hypertension and its complications. Budd-Chiari syndrome and portal vein thrombosis in the absence of underlying liver disease share many risk factors, among which myeloproliferative neoplasms represent the most common; a rapid comprehensive work-up for risk factors of thrombosis is needed in these patients. Long-term anticoagulation is indicated in most patients. Portal vein thrombosis can also develop in patients with cirrhosis and in those with porto-sinusoidal vascular liver disease. The presence and nature of underlying liver disease impacts the management of portal vein thrombosis. Indications for anticoagulation in patients with cirrhosis are growing, while transjugular intrahepatic portosystemic shunt is now a second-line option. Due to the rarity of these diseases, studies yielding high-grade evidence are scarce. However, collaborative studies have provided new insight into the management of these patients. This article focuses on the causes, diagnosis, and management of patients with Budd-Chiari syndrome, portal vein thrombosis without underlying liver disease, or cirrhosis with non-malignant portal vein thrombosis.
Identifiants
pubmed: 36941824
doi: 10.1016/j.jhepr.2022.100667
pii: S2589-5559(22)00239-7
pmc: PMC10023986
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
100667Informations de copyright
© 2022 The Author(s).
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest that pertain to this work. Please refer to the accompanying ICMJE disclosure forms for further details.
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