Isostearic acid is an active component of imiquimod formulations used to induce psoriaform disease models.
Dermatitis
Imiquimod
Isostearic acid
Psoriasis
Journal
Inflammopharmacology
ISSN: 1568-5608
Titre abrégé: Inflammopharmacology
Pays: Switzerland
ID NLM: 9112626
Informations de publication
Date de publication:
Apr 2023
Apr 2023
Historique:
received:
02
12
2022
accepted:
19
02
2023
medline:
1
5
2023
pubmed:
22
3
2023
entrez:
21
3
2023
Statut:
ppublish
Résumé
Topical imiquimod based creams are indicated as immune stimulants for papillomas and various skin neoplasms. Imiquimod is considered a TLR7 ligand. These creams are also used in research to induce skin inflammation in mice as a model for psoriasis. We observed that this inflammatory response was not strictly imiquimod dependent and we set out to establish which components drive the proinflammatory effects. To this end, we examined the induction response in a BALB/cJRj mouse model, in which 50 mg of cream is applied to 2 cm
Identifiants
pubmed: 36943539
doi: 10.1007/s10787-023-01175-3
pii: 10.1007/s10787-023-01175-3
doi:
Substances chimiques
Imiquimod
P1QW714R7M
isostearic acid
X33R8U0062
Toll-Like Receptor 7
0
Cytokines
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
799-812Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG.
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