LogD-based modelling and ΔlogD as a proxy for pH-dependent action of ionizable chemicals reveal the relevance of both neutral and ionic species for fish embryotoxicity and possess great potential for practical application in the regulation of chemicals.

Animals Zebrafish Hydrogen-Ion Concentration Propranolol / toxicity Ions
Danio rerio EQS Ecotoxicity FET OECD 236 Pharmaceuticals

Journal

Water research
ISSN: 1879-2448
Titre abrégé: Water Res
Pays: England
ID NLM: 0105072

Informations de publication

Date de publication:
15 May 2023
Historique:
received: 08 12 2022
revised: 19 02 2023
accepted: 09 03 2023
medline: 18 4 2023
pubmed: 22 3 2023
entrez: 21 3 2023
Statut: ppublish

Résumé

Depending on the ambient pH, ionizable substances are present in varying proportions in their neutral or charged form. The extent to which these two chemical species contribute to the pH-dependant toxicity of ionizable chemicals and whether intracellular ion trapping has a decisive influence in this context is controversially discussed. Against this background, we determined the acute toxicity of 24 ionizable substances at up to 4 different pH values on the embryonic development of the zebrafish, Danio rerio, and supplemented this dataset with additional data from the literature. The LC

Identifiants

DOI: 10.1016/j.watres.2023.119864 PMID: 36944304
pubmed: 36944304
pii: S0043-1354(23)00299-3
doi: 10.1016/j.watres.2023.119864
pii:
doi:

Substances chimiques

Propranolol 9Y8NXQ24VQ
Ions 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

119864

Informations de copyright

Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors have no competing interests to declare

Auteurs

Heinz-R Köhler (HR)

Animal Physiological Ecology, Institute of Evolution and Ecology, University of Tübingen, Auf der Morgenstelle 5, Tübingen D-72076, Germany. Electronic address: heinz-r.koehler@uni-tuebingen.de.

Thomas Gräff (T)

Federal Environment Agency, Wörlitzer Platz 1, Dessau-Roßlau D-06844, Germany.

Mona Schweizer (M)

Animal Physiological Ecology, Institute of Evolution and Ecology, University of Tübingen, Auf der Morgenstelle 5, Tübingen D-72076, Germany.

Jasmin Blumhardt (J)

Animal Physiological Ecology, Institute of Evolution and Ecology, University of Tübingen, Auf der Morgenstelle 5, Tübingen D-72076, Germany.

Jasmin Burkhardt (J)

Animal Physiological Ecology, Institute of Evolution and Ecology, University of Tübingen, Auf der Morgenstelle 5, Tübingen D-72076, Germany.

Lisa Ehmann (L)

Animal Physiological Ecology, Institute of Evolution and Ecology, University of Tübingen, Auf der Morgenstelle 5, Tübingen D-72076, Germany.

Janine Hebel (J)

Animal Physiological Ecology, Institute of Evolution and Ecology, University of Tübingen, Auf der Morgenstelle 5, Tübingen D-72076, Germany.

Christoph Heid (C)

Animal Physiological Ecology, Institute of Evolution and Ecology, University of Tübingen, Auf der Morgenstelle 5, Tübingen D-72076, Germany.

Lone Kundy (L)

Animal Physiological Ecology, Institute of Evolution and Ecology, University of Tübingen, Auf der Morgenstelle 5, Tübingen D-72076, Germany.

Julia Kuttler (J)

Animal Physiological Ecology, Institute of Evolution and Ecology, University of Tübingen, Auf der Morgenstelle 5, Tübingen D-72076, Germany.

Miroslava Malusova (M)

Animal Physiological Ecology, Institute of Evolution and Ecology, University of Tübingen, Auf der Morgenstelle 5, Tübingen D-72076, Germany.

Friederike-Marie Moroff (FM)

Animal Physiological Ecology, Institute of Evolution and Ecology, University of Tübingen, Auf der Morgenstelle 5, Tübingen D-72076, Germany.

Anne-Frida Schlösinger (AF)

Animal Physiological Ecology, Institute of Evolution and Ecology, University of Tübingen, Auf der Morgenstelle 5, Tübingen D-72076, Germany.

Pia Schulze-Berge (P)

Animal Physiological Ecology, Institute of Evolution and Ecology, University of Tübingen, Auf der Morgenstelle 5, Tübingen D-72076, Germany.

Eleni I Panagopoulou (EI)

Department of Chemistry, Laboratory of Analytical Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, Athens GR-15771, Greece.

Dimitrios E Damalas (DE)

Department of Chemistry, Laboratory of Analytical Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, Athens GR-15771, Greece.

Nikolaos S Thomaidis (NS)

Department of Chemistry, Laboratory of Analytical Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, Athens GR-15771, Greece.

Rita Triebskorn (R)

Animal Physiological Ecology, Institute of Evolution and Ecology, University of Tübingen, Auf der Morgenstelle 5, Tübingen D-72076, Germany; Steinbeis-Transfer Center Ecotoxicology and Ecophysiology, Blumenstrasse 13, Rottenburg D-72108, Germany.

Dirk Maletzki (D)

Federal Environment Agency, Schichauweg 58, Berlin D-12307, Germany.

Ute Kühnen (U)

Federal Environment Agency, Wörlitzer Platz 1, Dessau-Roßlau D-06844, Germany.

Peter C von der Ohe (PC)

Federal Environment Agency, Wörlitzer Platz 1, Dessau-Roßlau D-06844, Germany. Electronic address: peter.vonderohe@uba.de.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › LogD-based modelling and ΔlogD as a proxy for...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Poissons › Cypriniformes › Cyprinidae › Danio zébré › LogD-based modelling and ΔlogD as a proxy for...
questionsmedicales.fr › Phénomènes chimiques › Concentration en ions d'hydrogène › LogD-based modelling and ΔlogD as a proxy for...
questionsmedicales.fr › Composés polycycliques › Hydrocarbures aromatiques polycycliques › Naphtalènes › Propranolol › LogD-based modelling and ΔlogD as a proxy for...
questionsmedicales.fr › Produits chimiques inorganiques › Électrolytes › Ions › LogD-based modelling and ΔlogD as a proxy for...