Massively parallel characterization of transcriptional regulatory elements in three diverse human cell types.

Journal

bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187

Informations de publication

Date de publication:
06 Mar 2023
Historique:
pubmed: 23 3 2023
medline: 23 3 2023
entrez: 22 3 2023
Statut: epublish

Résumé

The human genome contains millions of candidate

Identifiants

DOI: 10.1101/2023.03.05.531189 PMID: 36945371 PMC: PMC10028905
pubmed: 36945371
doi: 10.1101/2023.03.05.531189
pmc: PMC10028905
pii:
doi:

Types de publication

Preprint

Langues

eng

Subventions

Organisme : NIDDK NIH HHS
ID : P30 DK098722
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK124769
Pays : United States
Organisme : NHGRI NIH HHS
ID : UM1 HG011966
Pays : United States

Déclaration de conflit d'intérêts

Competing interests. V.A. is an employee of Sanofi Pasteur Inc. J.S. is a scientific advisory board member, consultant and/or co-founder of Cajal Neuroscience, Guardant Health, Maze Therapeutics, Camp4 Therapeutics, Phase Genomics, Adaptive Biotechnologies, Scale Biosciences, Sixth Street Capital, and Pacific Biosciences. N.A. is the cofounder and on the scientific advisory board of Regel Therapeutics and receives funding from BioMarin Pharmaceutical Incorporated. All other authors declare no competing interests.

Auteurs

Vikram Agarwal (V)

Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA.
mRNA Center of Excellence, Sanofi Pasteur Inc., Waltham, MA 02451, USA.

Fumitaka Inoue (F)

Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA 94158, USA.
Institute for Human Genetics, University of California San Francisco, San Francisco, CA 94158, USA.
Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University, Kyoto, Japan.

Max Schubach (M)

Berlin Institute of Health of Health at Charité - Universitätsmedizin Berlin, 10178, Berlin, Germany.

Beth K Martin (BK)

Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA.

Pyaree Mohan Dash (PM)

Berlin Institute of Health of Health at Charité - Universitätsmedizin Berlin, 10178, Berlin, Germany.

Zicong Zhang (Z)

Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University, Kyoto, Japan.

Ajuni Sohota (A)

Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA 94158, USA.
Institute for Human Genetics, University of California San Francisco, San Francisco, CA 94158, USA.

William Stafford Noble (WS)

Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA.
Paul G. Allen School of Computer Science and Engineering, University of Washington, Seattle, WA, USA.

Galip Gürkan Yardimci (GG)

Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA.
Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA.
Cancer Early Detection Advanced Research Center, Oregon Health and Science University, Portland, OR, USA.

Martin Kircher (M)

Berlin Institute of Health of Health at Charité - Universitätsmedizin Berlin, 10178, Berlin, Germany.
Institute of Human Genetics, University Medical Center Schleswig-Holstein, University of Lübeck, Lübeck, Germany.

Jay Shendure (J)

Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA.
Howard Hughes Medical Institute, Seattle, WA 98195, USA.
Brotman Baty Institute for Precision Medicine, University of Washington, Seattle, WA 98195, USA.
Allen Center for Cell Lineage Tracing, University of Washington, Seattle, WA 98195, USA.

Nadav Ahituv (N)

Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA 94158, USA.
Institute for Human Genetics, University of California San Francisco, San Francisco, CA 94158, USA.

Classifications MeSH