Transcriptional Induction of NF-kB-Inducing Kinase by E2F4/5 Facilitates Collective Invasion of Glioma Cells.
Journal
Research square
Titre abrégé: Res Sq
Pays: United States
ID NLM: 101768035
Informations de publication
Date de publication:
07 Mar 2023
07 Mar 2023
Historique:
entrez:
22
3
2023
pubmed:
23
3
2023
medline:
23
3
2023
Statut:
epublish
Résumé
The prognosis of high-grade gliomas, such as glioblastoma multiforme (GBM), is extremely poor due to the highly invasive nature of these aggressive cancers. Previous work has demonstrated that TNF-weak like factor (TWEAK) induction of the noncanonical NF-κB pathway increases the invasiveness of glioma cells in an NF-κB-inducing kinase (NIK)-dependent manner. While NIK activity is predominantly regulated at the posttranslational level, we show here that NIK (
Identifiants
pubmed: 36945490
doi: 10.21203/rs.3.rs-2622363/v1
pmc: PMC10029079
pii:
doi:
Types de publication
Preprint
Langues
eng
Subventions
Organisme : NINDS NIH HHS
ID : R01 NS082554
Pays : United States
Commentaires et corrections
Type : UpdateIn
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