Nature-Skin-Derived e-Skin as Versatile "Wound Therapy-Health Monitoring" Bioelectronic Skin-Scaffolds: Skin to Bio-e-Skin.
antibacterial properties
bioelectronic skin-scaffolds
multi-functions
natural skin
wound therapy-health monitoring
Journal
Advanced healthcare materials
ISSN: 2192-2659
Titre abrégé: Adv Healthc Mater
Pays: Germany
ID NLM: 101581613
Informations de publication
Date de publication:
08 2023
08 2023
Historique:
revised:
19
03
2023
received:
16
11
2022
medline:
9
8
2023
pubmed:
23
3
2023
entrez:
22
3
2023
Statut:
ppublish
Résumé
Electronic skins (e-skins) have the potential to turn into breakthroughs in biomedical applications. Herein, a novel acellular dermal matrix (ADM)-based bioelectronic skin (e-ADM) is used to fabricate versatile "wound therapy-health monitoring" tissue-nanoengineered skin scaffolds via a facile "one-pot" bio-compositing strategy to incorporate the conductive carbon nanotubes and self-assembled micro-copper oxide microspheres with a cicada-wing-like rough surface and nanocone microstructure. The e-ADM exhibits robust tensile strength (22 MPa), flexibility, biodegradability, electroactivity, and antibacterial properties. Interestingly, e-ADM exhibits the pH-responsive ability for intelligent command between sterilization and wound repair . Additionally, e-ADM enables accurate real-time monitoring of human activities, providing a novel flexible e-skin sensor to record injury and motions. In vitro and in vivo experiments show that with electrical stimulation, e-ADM could prominently facilitate cell growth and proliferation and further promote full-thickness skin wound healing, providing a comprehensive therapeutic strategy for smart sensing and tissue repair, guiding the development of high-performance "wound therapy-health monitoring" bioelectronic skin-scaffolds.
Identifiants
pubmed: 36946644
doi: 10.1002/adhm.202202971
doi:
Substances chimiques
Nanotubes, Carbon
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2202971Informations de copyright
© 2023 Wiley-VCH GmbH.
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