Alveolar Macrophages-Mediated Translocation of Intratracheally Delivered Perfluorocarbon Nanoparticles to Achieve Lung Cancer

Humans Macrophages, Alveolar Magnetic Resonance Imaging / methods Lung Neoplasms / drug therapy Nanoparticles Fluorocarbons
19F-MRI alveolar macrophages lung cancer nanoparticles perfluorocarbon

Journal

Nano letters
ISSN: 1530-6992
Titre abrégé: Nano Lett
Pays: United States
ID NLM: 101088070

Informations de publication

Date de publication:
12 04 2023
Historique:
medline: 13 4 2023
pubmed: 23 3 2023
entrez: 22 3 2023
Statut: ppublish

Résumé

Recent advances in intratracheal delivery strategies have sparked considerable biomedical interest in developing this promising approach for lung cancer diagnosis and treatment. However, there are very few relevant studies on the behavior and mechanism of imaging nanoparticles (NPs) after intratracheal delivery. Here, we found that nanosized perfluoro-15-crown-5-ether (PFCE NPs, ∼200 nm) exhibite significant

Identifiants

DOI: 10.1021/acs.nanolett.3c00354 PMID: 36947431
pubmed: 36947431
doi: 10.1021/acs.nanolett.3c00354
doi:

Substances chimiques

Fluorocarbons 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2964-2973

Auteurs

Hongbin Wang (H)

Department of Nuclear Medicine, The Fourth Hospital of Harbin Medical University, Harbin 150028, China.
NHC Key Laboratory of Molecular Probe and Targeted Diagnosis and Therapy, Molecular Imaging Research Center (MIRC), Harbin Medical University, Harbin 150028, China.
ORCID: 0000-0002-4670-7373

Xiaona Li (X)

Department of Nuclear Medicine, The Fourth Hospital of Harbin Medical University, Harbin 150028, China.
NHC Key Laboratory of Molecular Probe and Targeted Diagnosis and Therapy, Molecular Imaging Research Center (MIRC), Harbin Medical University, Harbin 150028, China.

Jing Wang (J)

Department of Nuclear Medicine, The Fourth Hospital of Harbin Medical University, Harbin 150028, China.
NHC Key Laboratory of Molecular Probe and Targeted Diagnosis and Therapy, Molecular Imaging Research Center (MIRC), Harbin Medical University, Harbin 150028, China.

Jiannan Wang (J)

Department of Nuclear Medicine, The Fourth Hospital of Harbin Medical University, Harbin 150028, China.
NHC Key Laboratory of Molecular Probe and Targeted Diagnosis and Therapy, Molecular Imaging Research Center (MIRC), Harbin Medical University, Harbin 150028, China.

Hongyan Zou (H)

Department of Nuclear Medicine, The Fourth Hospital of Harbin Medical University, Harbin 150028, China.
NHC Key Laboratory of Molecular Probe and Targeted Diagnosis and Therapy, Molecular Imaging Research Center (MIRC), Harbin Medical University, Harbin 150028, China.

Xuesong Hu (X)

Department of Nuclear Medicine, The Fourth Hospital of Harbin Medical University, Harbin 150028, China.
NHC Key Laboratory of Molecular Probe and Targeted Diagnosis and Therapy, Molecular Imaging Research Center (MIRC), Harbin Medical University, Harbin 150028, China.

Linqing Yang (L)

Department of Nuclear Medicine, The Fourth Hospital of Harbin Medical University, Harbin 150028, China.
NHC Key Laboratory of Molecular Probe and Targeted Diagnosis and Therapy, Molecular Imaging Research Center (MIRC), Harbin Medical University, Harbin 150028, China.

Penghui Shen (P)

Department of Nuclear Medicine, The Fourth Hospital of Harbin Medical University, Harbin 150028, China.
NHC Key Laboratory of Molecular Probe and Targeted Diagnosis and Therapy, Molecular Imaging Research Center (MIRC), Harbin Medical University, Harbin 150028, China.

Rong A (R)

Department of Nuclear Medicine, The Fourth Hospital of Harbin Medical University, Harbin 150028, China.
NHC Key Laboratory of Molecular Probe and Targeted Diagnosis and Therapy, Molecular Imaging Research Center (MIRC), Harbin Medical University, Harbin 150028, China.
ORCID: 0000-0002-6246-4682

Kaiqi Wang (K)

Department of Nuclear Medicine, The Fourth Hospital of Harbin Medical University, Harbin 150028, China.
NHC Key Laboratory of Molecular Probe and Targeted Diagnosis and Therapy, Molecular Imaging Research Center (MIRC), Harbin Medical University, Harbin 150028, China.

Yingbo Li (Y)

Department of Nuclear Medicine, The Fourth Hospital of Harbin Medical University, Harbin 150028, China.
NHC Key Laboratory of Molecular Probe and Targeted Diagnosis and Therapy, Molecular Imaging Research Center (MIRC), Harbin Medical University, Harbin 150028, China.
ORCID: 0000-0003-0453-4862

Jie Yang (J)

Department of Nuclear Medicine, The Fourth Hospital of Harbin Medical University, Harbin 150028, China.
NHC Key Laboratory of Molecular Probe and Targeted Diagnosis and Therapy, Molecular Imaging Research Center (MIRC), Harbin Medical University, Harbin 150028, China.
ORCID: 0000-0002-8636-2015

Kai Wang (K)

Department of Nuclear Medicine, The Fourth Hospital of Harbin Medical University, Harbin 150028, China.
NHC Key Laboratory of Molecular Probe and Targeted Diagnosis and Therapy, Molecular Imaging Research Center (MIRC), Harbin Medical University, Harbin 150028, China.

Lili Yang (L)

Department of Nuclear Medicine, The Fourth Hospital of Harbin Medical University, Harbin 150028, China.
NHC Key Laboratory of Molecular Probe and Targeted Diagnosis and Therapy, Molecular Imaging Research Center (MIRC), Harbin Medical University, Harbin 150028, China.

Lina Wu (L)

Department of Nuclear Medicine, The Fourth Hospital of Harbin Medical University, Harbin 150028, China.
NHC Key Laboratory of Molecular Probe and Targeted Diagnosis and Therapy, Molecular Imaging Research Center (MIRC), Harbin Medical University, Harbin 150028, China.
ORCID: 0000-0002-7517-3606

Xilin Sun (X)

Department of Nuclear Medicine, The Fourth Hospital of Harbin Medical University, Harbin 150028, China.
NHC Key Laboratory of Molecular Probe and Targeted Diagnosis and Therapy, Molecular Imaging Research Center (MIRC), Harbin Medical University, Harbin 150028, China.
ORCID: 0000-0001-7464-5117

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Alveolar Macrophages-Mediated Translocation of...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Macrophages › Macrophages alvéolaires › Alveolar Macrophages-Mediated Translocation of...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Alveolar Macrophages-Mediated Translocation of...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Tumeurs de l'appareil respiratoire › Tumeurs du poumon › Alveolar Macrophages-Mediated Translocation of...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Nanostructures › Nanoparticules › Alveolar Macrophages-Mediated Translocation of...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures halogénés › Hydrocarbures fluorés › Fluorocarbones › Alveolar Macrophages-Mediated Translocation of...