Selenium as a predictor of metabolic syndrome in middle age women.
PPAR-γ
metabolic syndrome
middle aged women
selenium
Journal
Aging
ISSN: 1945-4589
Titre abrégé: Aging (Albany NY)
Pays: United States
ID NLM: 101508617
Informations de publication
Date de publication:
21 03 2023
21 03 2023
Historique:
received:
04
12
2022
accepted:
04
03
2023
medline:
10
4
2023
pubmed:
23
3
2023
entrez:
22
3
2023
Statut:
ppublish
Résumé
Selenium plays an important role in metabolic homeostasis. It has been suggested that it may also affect the expression and activity of PPAR-γ. The aim of study was to analyze the relationships between these variables in the context of the health of women, for whom the risk of MetS increases with age. The study involved 390 women in middle age. The stages of study: a survey-based part; anthropometric measurements; analysis of biological material (blood) in terms of glycemia, triglyceride, HDL, and selenium levels, as well as genetic analysis of the PPAR-γ polymorphisms. It was found that selenium may moderate the effect of the G allele of the PPAR-γ gene on the occurrence of elevated waist circumference (OR=1.030, 95%CI 1.005-1.057, p=0.020); and the effect of the C (OR=1.077, 95%CI 1.009-1.149, p=0.026) and the G alleles (OR=1.052, 95%CI 1.025-1.080, p<0.000) on the odds of elevated blood pressure. Women in whom HDL levels were not significantly reduced, had higher selenium levels (p=0.007). 1. The effect of selenium on MetS and its components has not been demonstrated. 2. The effect of individual alleles of the PPAR-γ gene on MetS and its components was not demonstrated. 3. The concentration of selenium may affect waist circumference in carriers of the G allele, and arterial hypertension in carriers of the C and G alleles by affecting the expression of PPAR-γ. 4. Higher selenium concentrations increased the odds of higher HDL levels in the group of subjects meeting the MetS criteria.
Sections du résumé
BACKGROUND
Selenium plays an important role in metabolic homeostasis. It has been suggested that it may also affect the expression and activity of PPAR-γ. The aim of study was to analyze the relationships between these variables in the context of the health of women, for whom the risk of MetS increases with age.
MATERIAL AND METHODS
The study involved 390 women in middle age. The stages of study: a survey-based part; anthropometric measurements; analysis of biological material (blood) in terms of glycemia, triglyceride, HDL, and selenium levels, as well as genetic analysis of the PPAR-γ polymorphisms.
RESULTS
It was found that selenium may moderate the effect of the G allele of the PPAR-γ gene on the occurrence of elevated waist circumference (OR=1.030, 95%CI 1.005-1.057, p=0.020); and the effect of the C (OR=1.077, 95%CI 1.009-1.149, p=0.026) and the G alleles (OR=1.052, 95%CI 1.025-1.080, p<0.000) on the odds of elevated blood pressure. Women in whom HDL levels were not significantly reduced, had higher selenium levels (p=0.007).
CONCLUSIONS
1. The effect of selenium on MetS and its components has not been demonstrated. 2. The effect of individual alleles of the PPAR-γ gene on MetS and its components was not demonstrated. 3. The concentration of selenium may affect waist circumference in carriers of the G allele, and arterial hypertension in carriers of the C and G alleles by affecting the expression of PPAR-γ. 4. Higher selenium concentrations increased the odds of higher HDL levels in the group of subjects meeting the MetS criteria.
Identifiants
pubmed: 36947700
pii: 204590
doi: 10.18632/aging.204590
pmc: PMC10085601
doi:
Substances chimiques
Selenium
H6241UJ22B
Peroxisome Proliferator-Activated Receptors
0
Triglycerides
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1734-1747Références
Curr Hypertens Rep. 2018 Feb 26;20(2):12
pubmed: 29480368
Expert Opin Drug Discov. 2015 Dec;10(12):1259-70
pubmed: 26479699
J Midlife Health. 2019 Oct-Dec;10(4):165-172
pubmed: 31942151
Int J Prev Med. 2019 Dec 10;10:210
pubmed: 31921402
J Hazard Mater. 2018 Sep 5;357:355-362
pubmed: 29909169
Nahrung. 1991;35(8):827-34
pubmed: 1780007
Acta Pharmacol Toxicol (Copenh). 1986;59 Suppl 7:317-24
pubmed: 3535376
Endocrinology. 2002 May;143(5):1705-16
pubmed: 11956152
BMJ Open. 2019 Jun 14;9(6):e025365
pubmed: 31201184
Mediators Inflamm. 2013;2013:549627
pubmed: 23781121
Cent Eur J Immunol. 2015;40(2):236-42
pubmed: 26557039
J Biol Chem. 2001 Oct 12;276(41):37731-4
pubmed: 11459852
Curr Med Res Opin. 2011 Jul;27(7):1431-8
pubmed: 21599553
Int J Mol Sci. 2021 Jan 15;22(2):
pubmed: 33467433
J Biosci. 2019 Dec;44(6):
pubmed: 31894131
Toxicology. 2017 Jul 15;387:43-56
pubmed: 28572025
Oxid Med Cell Longev. 2020 Apr 22;2020:5343014
pubmed: 32377302
Clin Dermatol. 2018 Jan - Feb;36(1):14-20
pubmed: 29241747
Food Nutr Res. 2017 Jul 6;61(1):1348866
pubmed: 28747869
Eur J Endocrinol. 2001 Mar;144(3):277-82
pubmed: 11248748
Int J Obes Relat Metab Disord. 2000 Apr;24(4):522-4
pubmed: 10805513
Biol Trace Elem Res. 2016 Jun;171(2):399-409
pubmed: 26546553
Endocrine. 2014 Aug;46(3):496-504
pubmed: 24190050
PLoS One. 2015 Jun 22;10(6):e0130876
pubmed: 26098747
BMC Public Health. 2010 Sep 21;10:564
pubmed: 20858268
Diabetologia. 2006 Oct;49(10):2427-36
pubmed: 16906479
Nutr Hosp. 2013 Sep;28 Suppl 5:44-55
pubmed: 24010743
JAMA. 2007 Dec 12;298(22):2634-43
pubmed: 18073359
Clin Biochem. 2009 Sep;42(13-14):1331-46
pubmed: 19501581
J Trace Elem Med Biol. 2015 Oct;32:189-94
pubmed: 26302928
Obes Res Clin Pract. 2013 Jul-Aug;7(4):e301-7
pubmed: 24306159
Trends Cardiovasc Med. 2016 May;26(4):364-73
pubmed: 26654259
Am J Clin Nutr. 2007 Oct;86(4):899-906
pubmed: 17921363
J Hepatol. 2011 Oct;55(4):920-32
pubmed: 21718726
Physiol Rev. 2013 Jan;93(1):359-404
pubmed: 23303913
Molecules. 2016 Nov 19;21(11):
pubmed: 27869771
Int J Mol Sci. 2020 Apr 09;21(7):
pubmed: 32283758
Circ Res. 2008 Feb 15;102(3):283-94
pubmed: 18276926
Neuropathol Appl Neurobiol. 2010 Dec;36(7):612-22
pubmed: 20626630
J Hypertens. 2003 Sep;21(9):1657-62
pubmed: 12923397
Mol Aspects Med. 2005 Aug-Oct;26(4-5):235-44
pubmed: 16125765
Pak J Pharm Sci. 2016 Sep;29(5):1719-1725
pubmed: 27731835
Front Med. 2018 Dec;12(6):601-607
pubmed: 30413949
J Atheroscler Thromb. 2005;12(6):295-300
pubmed: 16394610
J Trace Elem Med Biol. 2013 Apr;27(2):112-6
pubmed: 23199701
Biol Trace Elem Res. 2018 Jun;183(2):218-225
pubmed: 28875327
Food Funct. 2018 Jun 20;9(6):3155-3165
pubmed: 29862408
Nutr Res. 2009 Jan;29(1):41-8
pubmed: 19185776
Int J Obes (Lond). 2011 Aug;35(8):1031-40
pubmed: 21042321
Diabetologia. 2005 Jun;48(6):1180-8
pubmed: 15887043
Diabet Med. 2006 May;23(5):469-80
pubmed: 16681555
J Cardiovasc Risk. 1996 Feb;3(1):18-25
pubmed: 8783027
Clin Chim Acta. 1984 Sep 15;142(1):1-10
pubmed: 6478618
Lancet. 2012 Mar 31;379(9822):1256-68
pubmed: 22381456
Biol Trace Elem Res. 2008 Summer;123(1-3):58-65
pubmed: 18288450
Proc Natl Acad Sci U S A. 2005 Apr 26;102(17):6207-12
pubmed: 15833818
Aging (Albany NY). 2018 Jan 9;10(1):72-82
pubmed: 29315078
PLoS One. 2012;7(9):e45269
pubmed: 23028897
Clin Chem. 1999 Aug;45(8 Pt 2):1339-45
pubmed: 10430816