Therapeutic application of natural products: NAD
Diseases
NAD(+) metabolism
Natural products
Nicotinamide adenine dinucleotide
Toxicology
Journal
Phytomedicine : international journal of phytotherapy and phytopharmacology
ISSN: 1618-095X
Titre abrégé: Phytomedicine
Pays: Germany
ID NLM: 9438794
Informations de publication
Date de publication:
Jun 2023
Jun 2023
Historique:
received:
03
12
2022
revised:
01
03
2023
accepted:
12
03
2023
medline:
26
4
2023
pubmed:
23
3
2023
entrez:
22
3
2023
Statut:
ppublish
Résumé
Nicotinamide adenine dinucleotide (NAD To summarize the latest findings on the prevention and treatment of various diseases through the regulation of NAD PubMed, Web of Science, and ScienceDirect were searched using the keywords "natural products sources," "toxicology," "NAD We found that the natural products mainly include phenols (curcumin, cyclocurcumin, 4-hydroxybenzyl alcohol, salvianolic acid B, pterostilbene, EGCG), flavonoids (pinostrobin, apigenin, acacetin, tilianin, kaempferol, quercetin, isoliquiritigenin, luteolin, silybin, hydroxysafflor yellow A, scutellarin), glycosides (salidroside), quinones (emodin, embelin, β-LAPachone, shikonin), terpenoids (notoginsenoside R1, ginsenoside F2, ginsenoside Rd, ginsenoside Rb1, ginsenoside Rg3, thymoquinone, genipin), pyrazines (tetramethylpyrazine), alkaloids (evodiamine, berberine), and phenylpropanoids (ferulic acid). These natural products have antioxidant, energy-producing, anti-inflammatory, anti-apoptotic and anti-aging effects, which mainly influence the NAMPT/NAD We evaluated the toxic effects of natural products and summarized the available clinical trials on NAD
Sections du résumé
BACKGROUND
BACKGROUND
Nicotinamide adenine dinucleotide (NAD
PURPOSE
OBJECTIVE
To summarize the latest findings on the prevention and treatment of various diseases through the regulation of NAD
METHODS
METHODS
PubMed, Web of Science, and ScienceDirect were searched using the keywords "natural products sources," "toxicology," "NAD
RESULTS
RESULTS
We found that the natural products mainly include phenols (curcumin, cyclocurcumin, 4-hydroxybenzyl alcohol, salvianolic acid B, pterostilbene, EGCG), flavonoids (pinostrobin, apigenin, acacetin, tilianin, kaempferol, quercetin, isoliquiritigenin, luteolin, silybin, hydroxysafflor yellow A, scutellarin), glycosides (salidroside), quinones (emodin, embelin, β-LAPachone, shikonin), terpenoids (notoginsenoside R1, ginsenoside F2, ginsenoside Rd, ginsenoside Rb1, ginsenoside Rg3, thymoquinone, genipin), pyrazines (tetramethylpyrazine), alkaloids (evodiamine, berberine), and phenylpropanoids (ferulic acid). These natural products have antioxidant, energy-producing, anti-inflammatory, anti-apoptotic and anti-aging effects, which mainly influence the NAMPT/NAD
CONCLUSION
CONCLUSIONS
We evaluated the toxic effects of natural products and summarized the available clinical trials on NAD
Identifiants
pubmed: 36948143
pii: S0944-7113(23)00129-0
doi: 10.1016/j.phymed.2023.154768
pii:
doi:
Substances chimiques
NAD
0U46U6E8UK
Biological Products
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
154768Informations de copyright
Copyright © 2023. Published by Elsevier GmbH.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.