Advancing cell-based cancer immunotherapy through stem cell engineering.
CRISPR-Cas9
T cell
T cell receptor
allogeneic off-the-shelf cell therapy
allorejection
cancer immunotherapy
chimeric antigen receptor
embryonic stem cell
feeder-free culture
gamma delta T cell
gene engineering
graft-versus-host disease
hematopoietic stem cell
immune cell
induced pluripotent stem cell
invariant natural killer T cell
lentivector
mucosal-associated invariant T cell
natural killer cell
stem cell
Journal
Cell stem cell
ISSN: 1875-9777
Titre abrégé: Cell Stem Cell
Pays: United States
ID NLM: 101311472
Informations de publication
Date de publication:
04 05 2023
04 05 2023
Historique:
received:
17
05
2022
revised:
04
01
2023
accepted:
22
02
2023
pmc-release:
04
05
2024
medline:
8
5
2023
pubmed:
23
3
2023
entrez:
22
3
2023
Statut:
ppublish
Résumé
Advances in cell-based therapy, particularly CAR-T cell therapy, have transformed the treatment of hematological malignancies. Although an important step forward for the field, autologous CAR-T therapies are hindered by high costs, manufacturing challenges, and limited efficacy against solid tumors. With ongoing progress in gene editing and culture techniques, engineered stem cells and their application in cell therapy are poised to address some of these challenges. Here, we review stem cell-based immunotherapy approaches, stem cell sources, gene engineering and manufacturing strategies, therapeutic platforms, and clinical trials, as well as challenges and future directions for the field.
Identifiants
pubmed: 36948187
pii: S1934-5909(23)00070-X
doi: 10.1016/j.stem.2023.02.009
pmc: PMC10164150
mid: NIHMS1879730
pii:
doi:
Substances chimiques
Receptors, Chimeric Antigen
0
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
592-610Subventions
Organisme : NCI NIH HHS
ID : DP2 CA196335
Pays : United States
Informations de copyright
Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests Y.-R.L., Z.S.D., P.W., and L.Y. are inventors on patents relating to this manuscript. Y.Y. is currently an employee of the Fate Therapeutics. P.W. is a co-founder, stockholder, consultant, and advisory board member of HRain Biotechnology, TCRCure Biopharma, and Appia Bio. L.Y. is a scientific advisor to AlzChem and Amberstone Biosciences and a co-founder, stockholder, and advisory board member of Appia Bio. None of the declared companies contributed to or directed any of the writing of this manuscript.
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