Imported rickettsial infections to the United Kingdom, 2015-2020.

Humans Scrub Typhus / diagnosis Doxycycline / therapeutic use Typhus, Epidemic Louse-Borne Rickettsia Infections / diagnosis Rickettsia Spotted Fever Group Rickettsiosis / diagnosis
Eschar Fever Murine typhus Rickettsia Scrub typhus Spotted fever Tick

Journal

The Journal of infection
ISSN: 1532-2742
Titre abrégé: J Infect
Pays: England
ID NLM: 7908424

Informations de publication

Date de publication:
05 2023
Historique:
received: 17 01 2023
revised: 13 03 2023
accepted: 15 03 2023
medline: 1 5 2023
pubmed: 23 3 2023
entrez: 22 3 2023
Statut: ppublish

Résumé

The burden of imported rickettsial infection in the UK is not previously described. This retrospective review identifies rickettsial cases diagnosed at the national reference laboratory between 2015 and 2022. Samples testing positive for spotted fever group, typhus group, and scrub typhus IgG/IgM on acute and convalescent blood samples, and/or PCR on tissue/blood were categorized as suspected, confirmed or past infection. 220 patients had rickettsioses, and the commonest import was acute spotted fever group infection (61%, 125/205), 54% (62/114) from South Africa. In acute typhus group cases, 60% (40/67) were from Southeast Asia. One patient with Rickettsia typhi bacteremia died. Scrub typhus group infections (5%, 10/205) were exclusively from Asia and the Western Pacific regions. Overall, 43% of confirmed cases (39/91) had not received doxycycline prior to results. Rickettsial infections are important and under-recognized causes of imported fever in the UK. Thorough history, examination, and timely treatment with doxycycline should be considered if there is suspicion of Rickettsia infection before testing.

Identifiants

DOI: 10.1016/j.jinf.2023.03.015 PMID: 36948252
pubmed: 36948252
pii: S0163-4453(23)00144-5
doi: 10.1016/j.jinf.2023.03.015
pii:
doi:

Substances chimiques

Doxycycline N12000U13O

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

446-452

Informations de copyright

Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.

Auteurs

Clare E Warrell (CE)

Rare and Imported Pathogens Laboratory, Salisbury, UK; London School of Hygiene and Tropical Medicine, London, UK. Electronic address: clare.warrell@ukhsa.gov.uk.

Jane Osborne (J)

Rare and Imported Pathogens Laboratory, Salisbury, UK.

Laura Nabarro (L)

Hospital for Tropical Diseaess, London, UCLH, UK.

Barry Gibney (B)

Rare and Imported Pathogens Laboratory, Salisbury, UK.

Daniel P Carter (DP)

Rare and Imported Pathogens Laboratory, Salisbury, UK.

Jennifer Warner (J)

Rare and Imported Pathogens Laboratory, Salisbury, UK.

Catherine F Houlihan (CF)

Rare and Imported Pathogens Laboratory, Salisbury, UK; Hospital for Tropical Diseaess, London, UCLH, UK; Department of Clinical Virology UCLH, UK; Infection and Immunity, University College London, UK.

Timothy J G Brooks (TJG)

Rare and Imported Pathogens Laboratory, Salisbury, UK.

Tommy Rampling (T)

Rare and Imported Pathogens Laboratory, Salisbury, UK; Hospital for Tropical Diseaess, London, UCLH, UK; Infection and Immunity, University College London, UK.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Imported rickettsial infections to the United...
questionsmedicales.fr › Infection › Maladies vectorielles › Infections à Rickettsiaceae › Fièvre fluviale du Japon › Imported rickettsial infections to the United...
questionsmedicales.fr › Composés polycycliques › Hydrocarbures aromatiques polycycliques › Naphtacènes › Tétracyclines › Doxycycline › Imported rickettsial infections to the United...
questionsmedicales.fr › Infection › Maladies vectorielles › Infections à Rickettsiaceae › Rickettsioses › Typhus épidémique à poux › Imported rickettsial infections to the United...
questionsmedicales.fr › Infection › Maladies vectorielles › Infections à Rickettsiaceae › Rickettsioses › Imported rickettsial infections to the United...
questionsmedicales.fr › Bactéries › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › Imported rickettsial infections to the United...
questionsmedicales.fr › Infection › Maladies vectorielles › Maladies transmises par les tiques › Rickettsiose du groupe des fièvres boutonneuses › Imported rickettsial infections to the United...